Search Results - "Sigman, David"

Chemical nucleases by Sigman, David S, Mazumder, Abhijit, Perrin, David M

“…The reactivities and applications of abiological, nucleolytic, redox-active coordination complexes are examined. Many oxidative scission reagents have been…”
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An Analysis of Clinical Outcomes Using Color Doppler Testicular Ultrasound for Testicular Torsion by Baker, Linda A, Sigman, David, Mathews, Ranjiv I, Benson, Jane, Docimo, Steven G

“…To delineate the clinical outcomes of color Doppler ultrasound (US) in the equivocal torsion patient. From 1992 to 1997, 130 patients (<23 years old) from 2…”
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Chemical Mechanism of DNA Scission by (1,10-Phenanthroline)copper. Carbonyl Oxygen of 5-Methylenefuranone Is Derived from Water by Meijler, Michael M, Zelenko, Ottilie, Sigman, David S

“…The tetrahedral 2:1 (1,10-phenanthroline)copper(I) complex ((OP) sub(2)Cu super(+)), cleaves the phosphodiester backbone of B-DNA under physiological…”
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Nuclease activity of 1,10-phenanthroline-copper ion by Sigman, David S

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Chemical nucleases by Sigman, David S

“…The ribose-directed reactivity distinguishes chemical nucleases from other chemical modification reagents which are widely used in nucleic acid chemistry. For…”
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Targeted chemical nucleases by Sigman, David S, Bruice, Thomas W, Mazumder, Abhijit, Sutton, Christopher L

“…The design of functional molecules has been an active area of research in chemistry and molecular biology during the past decade, encompassing topics such as…”
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The enzymes by Tamanoi, Fuyuhiko, Sigman, David S

“…This is the first compilation of protein lipidation enzymes. This volume summarizes recent dramatic developments regarding enzymes responsible for protein…”
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An Approach to Gene-Specific Transcription Inhibition Using Oligonucleotides Complementary to the Template Strand of the Open Complex by Milne, Lisa, Xu, Yue, Perrin, David M., Sigman, David S.

“…The single-stranded region of DNA within the open complex of transcriptionally active genes provides a unique target for the design of gene-specific…”
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Protease Activity of 1,10-Phenanthroline−Copper(I). Targeted Scission of the Catalytic Site of Carbonic Anhydrase by Gallagher, James, Zelenko, Ottilie, Walts, Avram D, Sigman, David S

“…To investigate the mechanism of scission of proteins by the chemical cleaving agent 1,10-phenanthroline−copper, the active sites of human carbonic anydrase I…”
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Helix Packing of Lactose Permease in Escherichia coli Studied by Site- Directed Chemical Cleavage by Wu, Jianhua, Perrin, David M., Sigman, David S., Kaback, H. Ronald

“…Biotinylated lactose permease from Escherichia coli containing a single-cysteine residue at position 330 (helix X) or at position 147, 148, or 149 (helix V)…”
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Energy Coupling and Molecular Motors by Tamanoi, Fuyuhiko, Hackney, David D

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Chemical Nuclease Activity of 1,10-Phenanthroline−Copper. Isotopic Probes of Mechanism by Zelenko, Ottilie, Gallagher, James, Xu, Y, Sigman, David S

“…The chemical nuclease 1,10-phenanthroline−copper cleaves DNA by oxidative attack on the deoxyribose moiety yielding 3‘- and 5‘-phosphomonoesters, free purine…”
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Nuclease activity of 1,10-phenanthroline-copper: kinetic mechanism by Thederahn, Theodore B, Kuwabara, Michio D, Larsen, Teresa A, Sigman, David S

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Footprinting DNA-protein complexes in situ following gel retardation assays using 1,10-phenanthroline-copper ion: Escherichia coli RNA polymerase-lac promoter complexes by Kuwabara, Michio, Sigman, David S

“…Protein-DNA complexes isolated in gel retardation assays can be digested within the acrylamide matrix by the nuclease activity of 1,10-phenanthroline-copper…”
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Site‐specific DNA cleavage of synthetic NarL sites by an engineered Escherichia coli NarL protein–1,10‐phenanthroline cleaving agent by Xiao, Gaoping, Cole, Daniel L., Gunsalus, Robert P., Sigman, David S., Chen, Chi‐Hong B.

“…The NarL response regulatory protein of Escherichia coli has been engineered by covalent modification with 1,10‐phenanthroline (OP) to create a set of…”
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Sequence-specific modification of guanosine in DNA by a C60-linked deoxyoligonucleotide: Evidence for a non-singlet oxygen mechanism by An, Yi-Zhong, Chen, Chi-Hong B., Anderson, Jamey L., Sigman, David S., Foote, Christopher S., Rubin, Yves

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Transcription inhibition using modified pentanucleotides by Hwang, Jae-Taeg, Baltasar, Francis E., Cole, Daniel L., Sigman, David S., Chen, Chi-hong B., Greenberg, Marc M.

“…Inhibition of gene expression was recently achieved by targeting the transcriptionally competent open complex using relatively short, pentameric modified…”
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Variable Structures of Fis-DNA Complexes Determined by Flanking DNA – Protein Contacts by Pan, Clark Q., Finkel, Steven E., Cramton, Sarah E., Feng, Jin-An, Sigman, David S., Johnson, Reid C.

“…The Fis protein from Escherichia coliand Salmonella typhimuriumregulates many diverse reactions including recombination, transcription, and replication and is…”
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Nuclease activity of 1,10-phenanthroline-copper ion. Conformational analysis and footprinting of the lac operon by Spassky, Annick, Sigman, David S

“…The nuclease activity of 1,10-phenanthroline-copper [(OP)2Cu+] preferentially nicks the wild-type, Ps, and L8-UV-5 lac promoters in the conserved promoter…”
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Nuclease activity of 1,10-phenanthroline-copper ion. Chemistry of deoxyribose oxidation by Goyne, Thomas E, Sigman, David S

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