Search Results - "Sigel, C W"

Baquiloprim, a new antifolate antibacterial: in vitro activity and pharmacokinetic properties in cattle by White, G, Daluge, S M, Sigel, C W, Ferone, R, Wilson, H R

“…During examination of the half-lives in cattle of a series of 5-substituted diaminobenzyl-pyrimidines, it was found that replacement of the phenyl ring of…”
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Pharmacokinetics and disposition in the rat of a DNA intercalator 502U83 by Patel, D K, Lewis, R P, Hinton, M L, Schroeder, D H, Shockcor, J P, Johnson, R L, Sigel, C W

“…The pharmacokinetics, metabolism, and qualitative tissue distribution of 502U83, a compound with antineoplastic activity, were examined in the rat. After an…”
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Disposition, metabolism, and excretion of the anticancer agent crisnatol in the rat by Patel, D K, Woolley, Jr, J L, Shcokcor, J P, Johnson, R L, Taylor, L C, Sigel, C W

“…Disposition and metabolism of crisnatol (14C-labeled), a novel antitumor agent, was examined after po and iv administration to rats. After both routes of drug…”
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The disposition and metabolism of [14C]piritrexim in rats after intravenous and oral administration by Woolley, J L, Deangelis, D V, Crouch, R C, Shockcor, J P, Sigel, C W

“…The disposition of [14C]piritrexim in male rats after iv (5 and 10 mg/kg) and po (5, 10, and 20 mg/kg) doses was studied. After an iv dose of 10 mg/kg, rats…”
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The disposition and metabolism of [14C]piritrexim in dogs after intravenous and oral administration by Woolley, J L, Deangelis, D V, Grace, M E, Liao, S H, Crouch, R C, Sigel, C W

“…The disposition of [14C]piritrexim ([14C]PTX) in male dogs after iv and po doses of 1.8 mg/kg was examined. After either route of administration, greater than…”
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2,4-Diamino-5-benzylpyrimidines and analogs as antibacterial agents. 9. Lipophilic trimethoprim analogs as antigonococcal agents by Roth, B, Baccanari, D. P, Sigel, C. W, Hubbell, J. P, Eaddy, J, Kao, J. C, Grace, M. E, Rauckman, B. S

“…Lipophilic analogues of trimethoprim (1) bearing 3,5-dialkyl-4-hydroxy substituents in the benzene ring are much more active in vitro against Neisseria…”
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High-performance liquid chromatographic assay for the simultaneous measurement of trimethoprim and sulfamethoxazole in plasma or urine by DeAngelis, D V, Woolley, J L, Sigel, C W

“…Procedures for the simultaneous determination of trimethoprim (TMP) and sulfamethoxazole (SMX) in plasma or urine are reported. The drugs are extracted from…”
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Metabolism of a novel antitumor agent, crisnatol, by a human hepatoma cell line, Hep G2, and hepatic microsomes. Characterization of metabolites by Patel, D K, Shockcor, J P, Chang, S Y, Sigel, C W, Huber, B E

“…Metabolism of the anticancer agent crisnatol was investigated using a human hepatoma cell line, Hep G2, and human liver microsomes. Crisnatol was metabolized…”
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Lipid-soluble inhibitors of dihydrofolate reductase. I. Kinetics, tissue distribution, and extent of metabolism of pyrimethamine, metoprine, and etoprine in the rat, dog, and man by Cavallito, J C, Nichol, C A, Brenckman, Jr, W D, Deangelis, R L, Stickney, D R, Simmons, W S, Sigel, C W

“…With the aim of developing anticancer compounds which overcome some of the clinical limitations of the polar dihydrofolate reductase inhibitor, methotrexate,…”
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Competitive protein binding assay for piritrexim by Woolley, Jr, J L, Ringstad, J L, Sigel, C W

“…A competitive protein binding assay for piritrexim (PTX, 1) that makes use of a commercially available radioassay kit for methotrexate has been developed…”
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Diffusion of Trimethoprim and Sulfamethoxazole from Susceptibility Disks into Agar Medium by Grace, M E, Bushby, S R, Sigel, C W

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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The role of dietary nitrate and nitrite in the reductive deamination of sulfadiazine by the rat, guinea pig, and neonatal calf by Woolley, Jr, J L, Sigel, C W

“…Previous metabolic depletion studies of 14C-sulfadiazine (SDZ) in the neonatal calf led to identification of two novel metabolites,…”
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Development of pharmacokinetic models for sulfonamides in food animals: metabolic depletion profile of sulfadiazine in the calf by Woolley, Jr, J L, Sigel, C W

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Pharmacokinetics of trimethoprim and sulfadiazine in the dog: urine concentrations after oral administration by Sigel, C W, Ling, G V, Bushby, S R, Woolley, Jr, J L, DeAngelis, D, Eure, S

“…Serial blood samples were obtained from 12 healthy adult dogs given equivalent subcutaneous and oral doses of the antibacterial combination,…”
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Serum concentrations of trimethoprim and sulfadiazine following oral paste administration to the horse by Sigel, C W, Byars, T D, Divers, T J, Murch, O, DeAngelis, D

“…Two fasted and 2 fed horses were dosed orally with a combined trimethoprim and sulfadiazine paste formulation at a dose of 35 mg (1:5 combined active…”
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Experimental induction of Proteus mirabilis cystitis in the pony and evaluation of therapy with trimethoprim-sulfadiazine by Divers, T J, Byars, T D, Murch, O, Sigel, C W

“…Proteus mirabilis cystitis was induced in 9 ponies by chemically eroding the bladder mucosa before the organism was inoculated. Comparisons were made in the…”
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Metabolism of Trimethoprim in Man and Measurement of a New Metabolite: A New Fluorescence Assay by Sigel, Carl W., Kunin, Calvin M., Grace, Michael E., Nichol, Charles A.

“…Urinary concentrations of trimethoprim (TMP) and its metabolites were measured in eight healthy subjects after oral administration of 160 mg of TMP in two…”
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Lipid-soluble diaminopyrimidine inhibitors of dihydrofolate reductase by Nichol, C A, Cavallito, J C, Woolley, J L, Sigel, C W

“…On the basis of activity against experimental tumors and potency as inhibitors of human dihydrofolate reductase, two compounds were selected for…”
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Evaluation of the lipid-soluble diaminopyrimidines, metoprine and etoprine, in the avian sarcoma virus rat glioma model by Serano, R D, Sigel, C W, Nichol, C A, Bigner, D D

“…Using the avian sarcoma virus (ASV) rat glioma model, we have evaluated the in vivo effectiveness of two lipid-soluble folate antagonists, metoprine (DDMP) and…”
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Tumor inhibitors. LXV. Bersenogenin, berscillogenin, and 3-epiberscillogenin, three new cytotoxic bufadienolides from Bersama abyssinica by Kupchan, S. Morris, Moniot, J. L, Sigel, C. W, Hemingway, Richard J

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