Search Results - "Sigaux, François"

Medicine of the future: providing disruptive technologies for a practice of precision, prevention, prediction, participation and reactivity, guaranteeing respect for the individual and a source of economic development by Sigaux, François

Get full text

Clonal selection in xenografted human T cell acute lymphoblastic leukemia recapitulates gain of malignancy at relapse by Clappier, Emmanuelle, Gerby, Bastien, Sigaux, François, Delord, Marc, Touzri, Farah, Hernandez, Lucie, Ballerini, Paola, Baruchel, André, Pflumio, Françoise, Soulier, Jean

“…Genomic studies in human acute lymphoblastic leukemia (ALL) have revealed clonal heterogeneity at diagnosis and clonal evolution at relapse. In this study, we…”
Get full text

Concurrent CDX2 cis-deregulation and UBTF::ATXN7L3 fusion define a novel high-risk subtype of B-cell ALL by Passet, Marie, Kim, Rathana, Gachet, Stéphanie, Sigaux, François, Chaumeil, Julie, Galland, Ava, Sexton, Thomas, Quentin, Samuel, Hernandez, Lucie, Larcher, Lise, Bergugnat, Hugo, Ye, Tao, Karasu, Nezih, Caye, Aurélie, Heizmann, Beate, Duluc, Isabelle, Chevallier, Patrice, Rousselot, Philippe, Huguet, Françoise, Leguay, Thibaut, Hunault, Mathilde, Pflumio, Françoise, Freund, Jean-Noël, Lobry, Camille, Lhéritier, Véronique, Dombret, Hervé, Domon-Dell, Claire, Soulier, Jean, Boissel, Nicolas, Clappier, Emmanuelle

“…Oncogenic alterations underlying B-cell acute lymphoblastic leukemia (B-ALL) in adults remain incompletely elucidated. To uncover novel oncogenic drivers, we…”
Get full text

PAX5 P80R mutation identifies a novel subtype of B-cell precursor acute lymphoblastic leukemia with favorable outcome by Passet, Marie, Boissel, Nicolas, Sigaux, François, Saillard, Colombe, Bargetzi, Mario, Ba, Ibrahima, Thomas, Xavier, Graux, Carlos, Chalandon, Yves, Leguay, Thibaut, Lengliné, Etienne, Konopacki, Johanna, Quentin, Samuel, Delabesse, Eric, Lafage-Pochitaloff, Marina, Pastoret, Cédric, Grardel, Nathalie, Asnafi, Vahid, Lhéritier, Véronique, Soulier, Jean, Dombret, Hervé, Clappier, Emmanuelle

Get full text

Insertional oncogenesis in 4 patients after retrovirus-mediated gene therapy of SCID-X1 by Hacein-Bey-Abina, Salima, Garrigue, Alexandrine, Wang, Gary P, Soulier, Jean, Lim, Annick, Morillon, Estelle, Clappier, Emmanuelle, Caccavelli, Laure, Delabesse, Eric, Beldjord, Kheira, Asnafi, Vahid, MacIntyre, Elizabeth, Dal Cortivo, Liliane, Radford, Isabelle, Brousse, Nicole, Sigaux, François, Moshous, Despina, Hauer, Julia, Borkhardt, Arndt, Belohradsky, Bernd H, Wintergerst, Uwe, Velez, Maria C, Leiva, Lily, Sorensen, Ricardo, Wulffraat, Nicolas, Blanche, Stéphane, Bushman, Frederic D, Fischer, Alain, Cavazzana-Calvo, Marina

“…Previously, several individuals with X-linked SCID (SCID-X1) were treated by gene therapy to restore the missing IL-2 receptor gamma (IL2RG) gene to CD34+ BM…”
Get full text

Clonal hematopoiesis driven by chromosome 1q/MDM4 trisomy defines a canonical route toward leukemia in Fanconi anemia by Sebert, Marie, Gachet, Stéphanie, Leblanc, Thierry, Rousseau, Alix, Bluteau, Olivier, Kim, Rathana, Ben Abdelali, Raouf, Sicre de Fontbrune, Flore, Maillard, Loïc, Fedronie, Carèle, Murigneux, Valentine, Bellenger, Léa, Naouar, Naira, Quentin, Samuel, Hernandez, Lucie, Vasquez, Nadia, Da Costa, Mélanie, Prata, Pedro H., Larcher, Lise, de Tersant, Marie, Duchmann, Matthieu, Raimbault, Anna, Trimoreau, Franck, Fenneteau, Odile, Cuccuini, Wendy, Gachard, Nathalie, Auger, Nathalie, Tueur, Giulia, Blanluet, Maud, Gazin, Claude, Souyri, Michèle, Langa Vives, Francina, Mendez-Bermudez, Aaron, Lapillonne, Hélène, Lengline, Etienne, Raffoux, Emmanuel, Fenaux, Pierre, Adès, Lionel, Forcade, Edouard, Jubert, Charlotte, Domenech, Carine, Strullu, Marion, Bruno, Bénédicte, Buchbinder, Nimrod, Thomas, Caroline, Petit, Arnaud, Leverger, Guy, Michel, Gérard, Cavazzana, Marina, Gluckman, Eliane, Bertrand, Yves, Boissel, Nicolas, Baruchel, André, Dalle, Jean-Hugues, Clappier, Emmanuelle, Gilson, Eric, Deriano, Ludovic, Chevret, Sylvie, Sigaux, François, Socié, Gérard, Stoppa-Lyonnet, Dominique, de Thé, Hugues, Antoniewski, Christophe, Bluteau, Dominique, Peffault de Latour, Régis, Soulier, Jean

“…Fanconi anemia (FA) patients experience chromosome instability, yielding hematopoietic stem/progenitor cell (HSPC) exhaustion and predisposition to…”
Get full text

HOXA genes are included in genetic and biologic networks defining human acute T-cell leukemia (T-ALL) by Soulier, Jean, Clappier, Emmanuelle, Cayuela, Jean-Michel, Regnault, Armelle, García-Peydró, Marina, Dombret, Hervé, Baruchel, André, Toribio, Maria-Luisa, Sigaux, François

“…Using a combination of molecular cytogenetic and large-scale expression analysis in human T-cell acute lymphoblastic leukemias (T-ALLs), we identified and…”
Get full text

Defective NK Cells in Acute Myeloid Leukemia Patients at Diagnosis Are Associated with Blast Transcriptional Signatures of Immune Evasion by Khaznadar, Zena, Boissel, Nicolas, Agaugué, Sophie, Henry, Guylaine, Cheok, Meyling, Vignon, Marguerite, Geromin, Daniela, Cayuela, Jean-Michel, Castaigne, Sylvie, Pautas, Cécile, Raffoux, Emmanuel, Lachuer, Joel, Sigaux, François, Preudhomme, Claude, Dombret, Hervé, Dulphy, Nicolas, Toubert, Antoine

“…Acute myeloid leukemia (AML) is a heterogeneous group of malignancies that may be sensitive to the NK cell antitumor response. However, NK cells are frequently…”
Get full text

Deletion of the protein tyrosine phosphatase gene PTPN2 in T-cell acute lymphoblastic leukemia by De Keersmaecker, Kim, Langerak, Anton W, El Chaar, Tiama, Sigaux, François, Soulier, Jean, Haferlach, Torsten, Lahortiga, Idoya, Ferrando, Adolfo A, Cools, Jan, Mentens, Nicole, Wlodarska, Iwona, Meijerink, Jules P P, Van Roosbroeck, Katrien, Vandenberghe, Peter, Kleppe, Maria, Graux, Carlos

“…PTPN2 (protein tyrosine phosphatase non-receptor type 2, also known as TC-PTP) is a cytosolic tyrosine phosphatase that functions as a negative regulator of a…”
Get full text

Myelodysplasia and leukemia of Fanconi anemia are associated with a specific pattern of genomic abnormalities that includes cryptic RUNX1/AML1 lesions by Quentin, Samuel, Cuccuini, Wendy, Ceccaldi, Raphael, Nibourel, Olivier, Pondarre, Corinne, Pagès, Marie-Pierre, Vasquez, Nadia, Dubois d'Enghien, Catherine, Larghero, Jérôme, Peffault de Latour, Régis, Rocha, Vanderson, Dalle, Jean-Hugues, Schneider, Pascale, Michallet, Mauricette, Michel, Gérard, Baruchel, André, Sigaux, François, Gluckman, Eliane, Leblanc, Thierry, Stoppa-Lyonnet, Dominique, Preudhomme, Claude, Socié, Gérard, Soulier, Jean

“…Fanconi anemia (FA) is a genetic condition associated with bone marrow (BM) failure, myelodysplasia (MDS), and acute myeloid leukemia (AML). We studied 57 FA…”
Get full text

The C-MYB locus is involved in chromosomal translocation and genomic duplications in human T-cell acute leukemia (T-ALL), the translocation defining a new T-ALL subtype in very young children by Clappier, Emmanuelle, Cuccuini, Wendy, Kalota, Anna, Crinquette, Antoine, Cayuela, Jean-Michel, Dik, Willem A., Langerak, Anton W., Montpellier, Bertrand, Nadel, Bertrand, Walrafen, Pierre, Delattre, Olivier, Aurias, Alain, Leblanc, Thierry, Dombret, Hervé, Gewirtz, Alan M., Baruchel, André, Sigaux, François, Soulier, Jean

“…The C-Myb transcription factor is essential for hematopoiesis, including in the T-cell lineage. The C-Myb locus is a common site of retroviral insertional…”
Get full text

Deletion 6q Drives T-cell Leukemia Progression by Ribosome Modulation by Gachet, Stéphanie, El-Chaar, Tiama, Avran, David, Genesca, Eulalia, Catez, Frédéric, Quentin, Samuel, Delord, Marc, Thérizols, Gabriel, Briot, Delphine, Meunier, Godelieve, Hernandez, Lucie, Pla, Marika, Smits, Willem K, Buijs-Gladdines, Jessica G, Van Loocke, Wouter, Menschaert, Gerben, André-Schmutz, Isabelle, Taghon, Tom, Van Vlierberghe, Pieter, Meijerink, Jules P, Baruchel, André, Dombret, Hervé, Clappier, Emmanuelle, Diaz, Jean-Jacques, Gazin, Claude, de Thé, Hugues, Sigaux, François, Soulier, Jean

“…Deletion of chromosome 6q is a well-recognized abnormality found in poor-prognosis T-cell acute lymphoblastic leukemia (T-ALL). Using integrated genomic…”
Get more information

PTPN2 negatively regulates oncogenic JAK1 in T-cell acute lymphoblastic leukemia by Kleppe, Maria, Soulier, Jean, Asnafi, Vahid, Mentens, Nicole, Hornakova, Tekla, Knoops, Laurent, Constantinescu, Stefan, Sigaux, François, Meijerink, Jules P., Vandenberghe, Peter, Tartaglia, Marco, Foa, Robin, Macintyre, Elizabeth, Haferlach, Torsten, Cools, Jan

“…We have recently reported inactivation of the tyrosine phosphatase PTPN2 (also known as TC-PTP) through deletion of the entire gene locus in ∼ 6% of T-cell…”
Get full text

For a digital and genomic medicine, based on collective experience and expertise by Sigaux, François

Get full text

Detection of somatic mosaicism and classification of Fanconi anemia patients by analysis of the FA/BRCA pathway by Soulier, Jean, Leblanc, Thierry, Larghero, Jérôme, Dastot, Hélène, Shimamura, Akiko, Guardiola, Philippe, Esperou, Hélène, Ferry, Christèle, Jubert, Charlotte, Feugeas, Jean-Paul, Henri, Annie, Toubert, Antoine, Socié, Gérard, Baruchel, André, Sigaux, François, D'Andrea, Alan D., Gluckman, Eliane

“…Fanconi anemia (FA) is characterized by congenital abnormalities, bone marrow failure, chromosome fragility, and cancer susceptibility. Eight FA-associated…”
Get full text

High imatinib dose overcomes insufficient response associated with ABCG2 haplotype in chronic myelogenous leukemia patients by Delord, Marc, Rousselot, Philippe, Cayuela, Jean Michel, Sigaux, François, Guilhot, Joëlle, Preudhomme, Claude, Guilhot, François, Loiseau, Pascale, Raffoux, Emmanuel, Geromin, Daniela, Génin, Emmanuelle, Calvo, Fabien, Bruzzoni-Giovanelli, Heriberto

“…Pharmacogenetic studies in chronic myelogenous leukemia (CML) typically use a candidate gene approach. In an alternative strategy, we analyzed the impact of…”
Get full text

Genetic polymorphisms associated with increased risk of developing chronic myelogenous leukemia by Bruzzoni-Giovanelli, Heriberto, González, Juan R, Sigaux, François, Villoutreix, Bruno O, Cayuela, Jean Michel, Guilhot, Joëlle, Preudhomme, Claude, Guilhot, François, Poyet, Jean-Luc, Rousselot, Philippe

“…Little is known about inherited factors associated with the risk of developing chronic myelogenous leukemia (CML). We used a dedicated DNA chip containing 16…”
Get full text

The power of one by Louvard, Daniel, Sigaux, François, Robine, Sylvie

“…A single mouse Lgr5-positive colon stem cell can be expanded into a three-dimensional organoid that, after transplant, contributes to the repair of injured…”
Get more information

Node based B cell lymphomas: toward in silico modelling of critical biological pathways involved in neoplastic cell transformation by Sigaux, François

Get full text

Identification of TMEM131L as a novel regulator of thymocyte proliferation in humans by Maharzi, Nesrine, Parietti, Véronique, Nelson, Elisabeth, Denti, Simona, Robledo-Sarmiento, Macarena, Setterblad, Niclas, Parcelier, Aude, Pla, Marika, Sigaux, François, Gluckman, Jean Claude, Canque, Bruno

“…In this study, we identify transmembrane protein 131-like (TMEM131L) as a novel regulator of thymocyte proliferation and demonstrate that it corresponds to a…”
Get full text