Search Results - "Sif, Saïd"

Protein arginine methyltransferase 5 (PRMT5) promotes survival of lymphoma cells via activation of WNT/β-catenin and AKT/GSK3β proliferative signaling by Chung, Jihyun, Karkhanis, Vrajesh, Baiocchi, Robert A., Sif, Saïd

“…Epigenetic regulation by the type II protein arginine methyltransferase, PRMT5, plays an essential role in the control of cancer cell proliferation and…”
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Protein Arginine Methyltransferase 5 Suppresses the Transcription of the RB Family of Tumor Suppressors in Leukemia and Lymphoma Cells by Wang, Li, Pal, Sharmistha, Sif, Saïd

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Interplay between chromatin remodelers and protein arginine methyltransferases by Pal, Sharmistha, Sif, Saïd

“…Chromatin modifying enzymes have emerged as key regulators of all DNA based processes, which control cell growth, development, and differentiation. Recently,…”
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Versatility of PRMT5-induced methylation in growth control and development by Karkhanis, Vrajesh, Hu, Yu-Jie, Baiocchi, Robert A., Imbalzano, Anthony N., Sif, Saïd

“…Arginine methylation governs important cellular processes that impact growth and proliferation, as well as differentiation and development. Through their…”
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The Protein Arginine Methyltransferase Prmt5 Is Required for Myogenesis because It Facilitates ATP-Dependent Chromatin Remodeling by Dacwag, Caroline S., Ohkawa, Yasuyuki, Pal, Sharmistha, Sif, Saïd, Imbalzano, Anthony N.

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Protein arginine methyltransferase 5 (PRMT5) activates WNT/β‐catenin signalling in breast cancer cells via epigenetic silencing of DKK1 and DKK3 by Shailesh, Harshita, Siveen, Kodappully S., Sif, Saïd

“…Protein arginine methyltransferase 5 (PRMT5) activity is dysregulated in many aggressive cancers and its enhanced levels are associated with increased tumour…”
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Protein arginine methyltransferase 5 represses tumor suppressor miRNAs that down-regulate CYCLIN D1 and c-MYC expression in aggressive B-cell lymphoma by Karkhanis, Vrajesh, Alinari, Lapo, Ozer, Hatice Gulcin, Chung, Jihyun, Zhang, Xiaoli, Sif, Saïd, Baiocchi, Robert A.

“…Protein arginine methyltransferase-5 (PRMT5) is overexpressed in aggressive B-cell non-Hodgkin's lymphomas, including mantle cell lymphoma and diffuse large…”
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Novel role of BRCA1 interacting C‐terminal helicase 1 (BRIP1) in breast tumour cell invasion by Rizeq, Balsam, Sif, Saïd, Nasrallah, Gheyath K., Ouhtit, Allal

“…Breast cancer (BC) is the most common malignancy and the leading cause of death in women worldwide. Only 5%‐10% of mutations in BRCA genes are associated with…”
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Protein Arginine Methyltransferase 7 Regulates Cellular Response to DNA Damage by Methylating Promoter Histones H2A and H4 of the Polymerase δ Catalytic Subunit Gene, POLD1 by Karkhanis, Vrajesh, Wang, Li, Tae, Sookil, Hu, Yu-Jie, Imbalzano, Anthony N., Sif, Saïd

“…Covalent modification of histones by protein arginine methyltransferases (PRMTs) impacts genome organization and gene expression. In this report, we show that…”
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Distinct Protein Arginine Methyltransferases Promote ATP-Dependent Chromatin Remodeling Function at Different Stages of Skeletal Muscle Differentiation by Dacwag, Caroline S., Bedford, Mark T., Sif, Saïd, Imbalzano, Anthony N.

“…Author's Correction ( vol. 33 , p. 4618 ) Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike…”
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Protein Arginine Methyltransferase 5 (PRMT5) Inhibition Induces Lymphoma Cell Death through Reactivation of the Retinoblastoma Tumor Suppressor Pathway and Polycomb Repressor Complex 2 (PRC2) Silencing by Chung, Jihyun, Karkhanis, Vrajesh, Tae, Sookil, Yan, Fengting, Smith, Porsha, Ayers, Leona W., Agostinelli, Claudio, Pileri, Stefano, Denis, Gerald V., Baiocchi, Robert A., Sif, Saïd

“…Epigenetic regulation mediated by lysine- and arginine-specific enzymes plays an essential role in tumorigenesis, and enhanced expression of the type II…”
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Low levels of miR-92b/96 induce PRMT5 translation and H3R8/H4R3 methylation in mantle cell lymphoma by Pal, Sharmistha, Baiocchi, Robert A, Byrd, John C, Grever, Michael R, Jacob, Samson T, Sif, Saïd

“…Protein arginine methyltransferase PRMT5 interacts with human SWI/SNF complexes and methylates histones H3R8 and H4R3. To elucidate the role of PRMT5 in human…”
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Bromodomain protein 7 interacts with PRMT5 and PRC2, and is involved in transcriptional repression of their target genes by Tae, Sookil, Karkhanis, Vrajesh, Velasco, Kevin, Yaneva, Mariana, Erdjument-Bromage, Hediye, Tempst, Paul, Sif, Saïd

“…Histone modification regulates gene expression, and one major regulatory step in this process is the ability of proteins that recognize epigenetic marks to…”
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Transcriptional and post-transcriptional control of adipocyte differentiation by Jumonji domain-containing protein 6 by Hu, Yu-Jie, Belaghzal, Houda, Hsiao, Wen-Yu, Qi, Jun, Bradner, James E, Guertin, David A, Sif, Saïd, Imbalzano, Anthony N

“…Jumonji domain-containing protein 6 (JMJD6) is a nuclear protein involved in histone modification, transcription and RNA processing. Although JMJD6 is crucial…”
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Human SWI/SNF-Associated PRMT5 Methylates Histone H3 Arginine 8 and Negatively Regulates Expression of ST7 and NM23 Tumor Suppressor Genes by Pal, Sharmistha, Vishwanath, Sheethal N., Erdjument-Bromage, Hediye, Tempst, Paul, Sif, Saïd

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Opposing calcium-dependent signalling pathways control skeletal muscle differentiation by regulating a chromatin remodelling enzyme by Nasipak, Brian T., Padilla-Benavides, Teresita, Green, Karin M., Leszyk, John D., Mao, Wenjie, Konda, Silvana, Sif, Saïd, Shaffer, Scott A., Ohkawa, Yasuyuki, Imbalzano, Anthony N.

“…Calcium signalling is important for differentiation-dependent gene expression, but is also involved in other cellular functions. Therefore, mechanisms must…”
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Protein arginine methyltransferase 5 (PRMT5) dysregulation in cancer by Shailesh, Harshita, Zakaria, Zain Z, Baiocchi, Robert, Sif, Saïd

“…Protein arginine methyltransferases (PRMTs) are known for their ability to catalyze methylation of specific arginine residues in a wide variety of cellular…”
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Protein Arginine Methyltransferase 5 (Prmt5) Promotes Gene Expression of Peroxisome Proliferator-Activated Receptor γ2 (PPARγ2) and Its Target Genes during Adipogenesis by LeBlanc, Scott E, Konda, Silvana, Wu, Qiong, Hu, Yu-Jie, Oslowski, Christine M, Sif, Saïd, Imbalzano, Anthony N

“…Regulation of adipose tissue formation by adipogenic-regulatory proteins has long been a topic of interest given the ever-increasing health concerns of obesity…”
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Brahma links the SWI/SNF chromatin-remodeling complex with MeCP2-dependent transcriptional silencing by El-Osta, Assam, K N, Harikrishnan, Chow, Maggie Z, Baker, Emma K, Pal, Sharmistha, Bassal, Sahar, Brasacchio, Daniella, Wang, Li, Craig, Jeff M, Jones, Peter L, Sif, Saïd

“…Transcriptional repression of methylated genes can be mediated by the methyl-CpG binding protein MeCP2. Here we show that human Brahma (Brm), a catalytic…”
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Distinct Protein Arginine Methyltransferases Promote ATP-Dependent Chromatin Remodeling Function at Different Stages of Skeletal Muscle Differentiation by Dacwag, Caroline S., Bedford, Mark T., Sif, Saïd, Imbalzano, Anthony N.

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