Search Results - "Siewert, Elmar"

Hepatic Cytochrome P450 Down-regulation During Aseptic Inflammation in the Mouse Is Interleukin 6 Dependent by Siewert, Elmar, Bort, Roque, Kluge, Reinhart, Heinrich, Peter C., Castell, José, Jover, Ramiro

“…Expression of cytochromes P450 (CYP) is markedly reduced during inflammatory processes. In vitro studies with hepatocytes have shown that cytokines generated…”
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Cytokine blockade inhibits hepatic tissue inhibitor of metalloproteinase-1 expression and up-regulates matrix metalloproteinase-9 in toxic liver injury by Roderfeld, Martin, Geier, Andreas, Dietrich, Christoph G., Siewert, Elmar, Jansen, Bettina, Gartung, Carsten, Roeb, Elke

“…: Background: Tissue inhibitor of metalloproteinases (TIMP)‐1, the most important endogenous inhibitor of matrix metalloproteinases, plays a pivotal role in…”
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Interleukin-6 plays a crucial role in the hepatic expression of SOCS3 during acute inflammatory processes in vivo by Yang, Xiang-Ping, Schaper, Fred, Teubner, Andreas, Lammert, Frank, Heinrich, Peter C., Matern, Siegfried, Siewert, Elmar

“…Interleukin-6 is mandatory for liver regeneration after injury and for the hepatic expression of acute phase proteins and cytochrome P450 enzymes during…”
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Common heterozygous hemochromatosis gene mutations are risk factors for inflammation and fibrosis in chronic hepatitis C by Geier, Andreas, Reugels, Michael, Weiskirchen, Ralf, Wasmuth, Hermann E., Dietrich, Christoph G., Siewert, Elmar, Gartung, Carsten, Lorenzen, Johann, Bosserhoff, Anja K., Brügmann, Marc, Gressner, Axel M., Matern, Siegfried, Lammert, Frank

“…: 
Background: Chronic hepatitis C is frequently associated with increased hepatic iron stores. It remains controversial whether heterozygous mutations of…”
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Recurrent thrombotic occlusion of a transjugular intrahepatic portosystemic stent-shunt due to activated protein C resistance by Siewert, Elmar, Salzmann, Jan, Purucker, Edmund, Schürmann, Karl, Matern, Siegfried

“…The transjugular intrahepatic portosystemic stent-shunt （TIPS） has successfully been used in the management of refractory variceal bleeding and ascites in…”
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Patients with acute on chronic liver failure display ‘sepsis-like’ immune paralysis by Wasmuth, Hermann E., Kunz, Dagmar, Yagmur, Eray, Timmer-Stranghöner, Annette, Vidacek, Daniel, Siewert, Elmar, Bach, Jens, Geier, Andreas, Purucker, Edmund A., Gressner, Axel M., Matern, Siegfried, Lammert, Frank

“…Cellular immune depression is linked to high mortality in sepsis, but has yet to be systematically analysed in liver cirrhosis. The aim of the present study…”
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Interleukin-6 regulates hepatic transporters during acute-phase response by Siewert, Elmar, Dietrich, Christoph G., Lammert, Frank, Heinrich, Peter C., Matern, Siegfried, Gartung, Carsten, Geier, Andreas

“…Cholestasis develops during inflammatory conditions characterized by the release of cytokines like interleukin-6 (IL-6), which is the major player in the…”
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Determination of protein turnover rates in the JAK/STAT pathway using a radioactive pulse-chase approach by Dittrich, Anna, Siewert, Elmar, Schaper, Fred

“…The turnover rate of different protein species in a signal transduction network strongly affects the impact of the given species on the outcome of a stimulus…”
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Clinical Studies: Cytokine blockade inhibits hepatic tissue inhibitor of metalloproteinase-1 expression and up-regulates matrix metalloproteinase-9 in toxic liver injury by Roderfeld, Martin, Geier, Andreas, Dietrich, Christoph G, Siewert, Elmar, Jansen, Bettina, Gartung, Carsten, Roeb, Elke

“…Tissue inhibitor of metalloproteinases (TIMP)-1, the most important endogenous inhibitor of matrix metalloproteinases, plays a pivotal role in the pathogenesis…”
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Different protein turnover of interleukin‐6‐type cytokine signalling components by Siewert, Elmar, Müller‐Esterl, Werner, Starr, Robin, Heinrich, Peter C., Schaper, Fred

“…Interleukin (IL)‐6 and IL‐6‐type cytokines signal through the gp130/Jak/STAT signal transduction pathway. The key components involved are the signal…”
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Cutaneous mucinosis and skin necrosis complicates interferon alfacon-1 (consensus interferon) treatment of chronic hepatitis C by Siewert, E, Weyers, W, Dietrich, C G, Geier, A, Lammert, F, Matern, S

“…A 59-year-old Caucasian suffering from chronic hepatitis C started daily subcutaneous self-injections of interferon alfacon-1 (consensus interferon) according…”
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Hepatocyte growth factor/scatter factor (HGF/SF) signals via the STAT3/APRF transcription factor in human hepatoma cells and hepatocytes by Schaper, Fred, Siewert, Elmar, Gómez-Lechón, Maria José, Gatsios, Petros, Sachs, Martin, Birchmeier, Walter, Heinrich, Peter C, Castell, José

“…Acute phase protein expression is regulated by a variety of cytokines such as IL-1, IL-6, IL-11, tumour necrosis factor α, interferon-γ, oncostatin-M, leukemia…”
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Acute infectious mononucleosis-like syndrome due to infection with cytomegalovirus in immunocompetence by Siewert, Elmar, Geier, Andreas, Dietrich, Christoph G, Backes, Berthold, Matern, Siegfried, Gartung, Carsten

“…Infections by cytomegalovirus (CMV) cause substantial morbidity and mortality in immunocompromised patients, whereas immunocompetent individuals generally…”
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IL-6-type cytokines and signalling in inflammation by Heinrich, Peter C., Bode, Johannes G., Graeve, Lutz, Haan, Serge, Martens, Astrid, Müller-Newen, Gerhard, Nimmesgern, Ariane, Schaper, Fred, Schmitz, Jochen, Siewert, Elmar

“…Interleukin (IL)-6 was identified as a hepatocyte-stimulating factor more than 10 years ago [1]. Subsequently, the authors have proposed IL-6 to be the major…”
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