Search Results - "Siew Yeen CHAI"

Transcriptional signature in microglia associated with Aβ plaque phagocytosis by Grubman, Alexandra, Choo, Xin Yi, Chew, Gabriel, Ouyang, John F., Sun, Guizhi, Croft, Nathan P., Rossello, Fernando J., Simmons, Rebecca, Buckberry, Sam, Landin, Dulce Vargas, Pflueger, Jahnvi, Vandekolk, Teresa H., Abay, Zehra, Zhou, Yichen, Liu, Xiaodong, Chen, Joseph, Larcombe, Michael, Haynes, John M., McLean, Catriona, Williams, Sarah, Chai, Siew Yeen, Wilson, Trevor, Lister, Ryan, Pouton, Colin W., Purcell, Anthony W., Rackham, Owen J. L., Petretto, Enrico, Polo, Jose M.

“…The role of microglia cells in Alzheimer’s disease (AD) is well recognized, however their molecular and functional diversity remain unclear. Here, we isolated…”
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Identification and characterization of a new cognitive enhancer based on inhibition of insulin-regulated aminopeptidase by Albiston, Anthony L, Morton, Craig J, Ng, Hooi Ling, Pham, Vi, Yeatman, Holly R, Ye, Siying, Fernando, Ruani N, De Bundel, Dimitri, Ascher, David B, Mendelsohn, Frederick A.O, Parker, Michael W, Chai, Siew Yeen

“…Approximately one-quarter of people over the age of 65 are estimated to suffer some form of cognitive impairment, underscoring the need for effective…”
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Development of a sandwich ELISA to detect circulating, soluble IRAP as a potential disease biomarker by Vear, Anika, Thalmann, Claudia, Youngs, Kristina, Hannan, Natalie, Gaspari, Tracey, Chai, Siew Yeen

“…There is growing interest in the use of the enzyme, insulin regulated aminopeptidase (IRAP), as a biomarker for conditions such as cardio-metabolic diseases…”
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Inhibition of insulin-regulated aminopeptidase confers neuroprotection in a conscious model of ischemic stroke by Telianidis, Jonathon, Hunter, Andrew, Widdop, Robert, Kemp-Harper, Barbara, Pham, Vi, McCarthy, Claudia, Chai, Siew Yeen

“…Stroke is a leading cause of mortality and morbidity with a paucity of effective pharmacological treatments. We have previously identified insulin-regulated…”
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Different cross-presentation pathways in steady-state and inflammatory dendritic cells by Segura, Elodie, Albiston, Anthony L, Wicks, Ian P, Chai, Siew Yeen, Villadangos, José A

“…Presentation of exogenous antigens on MHC class I molecules, termed cross-presentation, is essential for the induction of CD8 T-cell responses and is carried…”
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Insulin-regulated aminopeptidase deficiency impairs cardiovascular adaptations and placental development during pregnancy by Walton, Sarah L, Mirabito Colafella, Katrina M, Ansari, Aneesa, Chai, Siew Yeen, Denton, Kate M

“…Insulin-regulated aminopeptidase (IRAP), an enzyme that cleaves vasoactive peptides including oxytocin and vasopressin, is suggested to play a role in…”
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Potentiation of cholinergic transmission in the rat hippocampus by angiotensin IV and LVV-hemorphin-7 by Lee, Joohyung, Chai, Siew-Yeen, Mendelsohn, Frederick A.O., Morris, Margaret J., Allen, Andrew M.

“…Recent evidence demonstrates that the fragment of angiotensin II, angiotensin II (3–8) termed angiotensin IV, binds with high affinity to a specific binding…”
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Sex- and time-dependent role of insulin regulated aminopeptidase in lipopolysaccharide-induced inflammation by Vear, Anika, Chakraborty, Amlan, Fahimi, Farnaz, Ferens, Dorota, Widdop, Robert, Samuel, Chrishan S, Gaspari, Tracey, van Endert, Peter M, Chai, Siew Yeen

“…The enzyme, insulin regulated aminopeptidase (IRAP), is expressed in multiple immune cells such as macrophages, dendritic cells and T cells, where it plays a…”
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Crystal structure of human insulin‐regulated aminopeptidase with specificity for cyclic peptides by Hermans, Stefan J., Ascher, David B., Hancock, Nancy C., Holien, Jessica K., Michell, Belinda J., Chai, Siew Yeen, Morton, Craig J., Parker, Michael W.

“…Insulin‐regulated aminopeptidase (IRAP or oxytocinase) is a membrane‐bound zinc‐metallopeptidase that cleaves neuroactive peptides in the brain and produces…”
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Alzheimer's, Angiotensin IV and an Aminopeptidase by Albiston, Anthony Lloyd, Fernando, Ruani, Ye, Siying, Peck, Grantley Ross, Chai, Siew Yeen

“…The angiotensin AT4 receptor was originally defined as the specific, high affinity binding site for the hexapeptide angiotensin IV (Ang IV). Subsequently, the…”
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Binding to and Inhibition of Insulin-Regulated Aminopeptidase by Macrocyclic Disulfides Enhances Spine Density by Diwakarla, Shanti, Nylander, Erik, Grönbladh, Alfhild, Vanga, Sudarsana Reddy, Khan, Yasmin Shamsudin, Gutiérrez-de-Terán, Hugo, Ng, Leelee, Pham, Vi, Sävmarker, Jonas, Lundbäck, Thomas, Jenmalm-Jensen, Annika, Andersson, Hanna, Engen, Karin, Rosenström, Ulrika, Larhed, Mats, Åqvist, Johan, Chai, Siew Yeen, Hallberg, Mathias

“…Angiotensin IV (Ang IV) and related peptide analogs, as well as nonpeptide inhibitors of insulin-regulated aminopeptidase (IRAP), have previously been shown to…”
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Is There an Interplay Between the Functional Domains of IRAP? by Vear, Anika, Gaspari, Tracey, Thompson, Philip, Chai, Siew Yeen

“…As a member of the M1 family of aminopeptidases, insulin regulated aminopeptidase (IRAP) is characterized by distinct binding motifs at the active site in the…”
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Insulin-Regulated Aminopeptidase Inhibition Ameliorates Metabolism in Obese Zucker Rats by Krskova, Katarina, Balazova, Lucia, Dobrocsyova, Viktoria, Olszanecki, Rafal, Suski, Maciej, Chai, Siew Yeen, Zorad, Štefan

“…The aim of our study was to determine the influence of inhibition of insulin-regulated aminopeptidase/oxytocinase (IRAP) on glucose tolerance and metabolism of…”
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Age-related reduction in brain ACE-2 is not exacerbated by Alzheimer’s disease pathology in mouse models of Alzheimer’s disease by MacLachlan, Robert, Evans, Charles E., Chai, Siew Yeen, Good, Mark A., Kehoe, Patrick Gavin, Miners, J. Scott

“…An imbalance in the circulatory and organ-specific renin-angiotensin system (RAS) pathways is associated with age-related dysfunction and disease including…”
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Editorial: Physiological, Pathological Roles and Pharmacology of Insulin Regulated Aminopeptidase by Chai, Siew Yeen, Gutiérrez-de-Terán, Hugo, Stratikos, Efstratios

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Evidence That the Angiotensin IV (AT4) Receptor Is the Enzyme Insulin-regulated Aminopeptidase by Albiston, Anthony L., McDowall, Sharon G., Matsacos, Duana, Sim, Pamela, Clune, Eleanor, Mustafa, Tomris, Lee, Joohyung, Mendelsohn, Frederick A.O., Simpson, Richard J., Connolly, Lisa M., Chai, Siew Yeen

“…Central infusion of angiotensin IV or its more stable analogues facilitates memory retention and retrieval in normal animals and reverses amnesia induced by…”
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Angiotensin IV and LVV-haemorphin 7 enhance spatial working memory in rats: Effects on hippocampal glucose levels and blood flow by De Bundel, Dimitri, Smolders, Ilse, Yang, Rui, Albiston, Anthony L., Michotte, Yvette, Chai, Siew Yeen

“…The IRAP ligands Angiotensin IV (Ang IV) and LVV-haemorphin 7 (LVV-H7) enhance performance in a range of memory paradigms in normal rats and ameliorate memory…”
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Interaction of the Akt Substrate, AS160, with the Glucose Transporter 4 Vesicle Marker Protein, Insulin-Regulated Aminopeptidase by Peck, Grantley R, Ye, Siying, Pham, Vi, Fernando, Ruani N, Macaulay, S. Lance, Chai, Siew Yeen, Albiston, Anthony L

“…Insulin-regulated aminopeptidase (IRAP), a marker of glucose transporter 4 (GLUT4) storage vesicles (GSVs), is the only protein known to traffic with GLUT4. In…”
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Gene knockout of insulin-regulated aminopeptidase: Loss of the specific binding site for angiotensin IV and age-related deficit in spatial memory by Albiston, Anthony L., Fernando, Ruani N., Yeatman, Holly R., Burns, Peta, Ng, Leelee, Daswani, Dina, Diwakarla, Shanti, Pham, Vi, Chai, Siew Yeen

“…The AT 4 ligands, angiotensin IV and LVV-hemorphin 7, elicit robust effects on facilitating memory by binding to a specific site in the brain historically…”
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Angiotensin AT4 ligands are potent, competitive inhibitors of insulin regulated aminopeptidase (IRAP) by Lew, Rebecca A., Mustafa, Tomris, Ye, Siying, McDowall, Sharon G., Chai, Siew Yeen, Albiston, Anthony L.

“…Angiotensin IV (Ang IV) exerts profound effects on memory and learning, a phenomenon ascribed to its binding to a specific AT4 receptor. However the AT4…”
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