Search Results - "Sievers, Philipp"

Practical implementation of DNA methylation and copy-number-based CNS tumor diagnostics: the Heidelberg experience by Capper, David, Stichel, Damian, Sahm, Felix, Jones, David T. W., Schrimpf, Daniel, Sill, Martin, Schmid, Simone, Hovestadt, Volker, Reuss, David E., Koelsche, Christian, Reinhardt, Annekathrin, Wefers, Annika K., Huang, Kristin, Sievers, Philipp, Ebrahimi, Azadeh, Schöler, Anne, Teichmann, Daniel, Koch, Arend, Hänggi, Daniel, Unterberg, Andreas, Platten, Michael, Wick, Wolfgang, Witt, Olaf, Milde, Till, Korshunov, Andrey, Pfister, Stefan M., von Deimling, Andreas

“…Recently, we described a machine learning approach for classification of central nervous system tumors based on the analysis of genome-wide DNA methylation…”
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CDKN2A/B homozygous deletion is associated with early recurrence in meningiomas by Sievers, Philipp, Hielscher, Thomas, Schrimpf, Daniel, Stichel, Damian, Reuss, David E., Berghoff, Anna S., Neidert, Marian C., Wirsching, Hans-Georg, Mawrin, Christian, Ketter, Ralf, Paulus, Werner, Reifenberger, Guido, Lamszus, Katrin, Westphal, Manfred, Etminan, Nima, Ratliff, Miriam, Herold-Mende, Christel, Pfister, Stefan M., Jones, David T. W., Weller, Michael, Harter, Patrick N., Wick, Wolfgang, Preusser, Matthias, von Deimling, Andreas, Sahm, Felix

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Reverse Engineering of Radical Polymerizations by Multi-Objective Optimization by Fiosina, Jelena, Sievers, Philipp, Kanagaraj, Gavaskar, Drache, Marco, Beuermann, Sabine

“…Reverse engineering is applied to identify optimum polymerization conditions for the synthesis of polymers with pre-defined properties. The proposed approach…”
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Response to trametinib treatment in progressive pediatric low-grade glioma patients by Selt, Florian, van Tilburg, Cornelis M., Bison, Brigitte, Sievers, Philipp, Harting, Inga, Ecker, Jonas, Pajtler, Kristian W., Sahm, Felix, Bahr, Annabelle, Simon, Michèle, Jones, David T. W., Well, Lennart, Mautner, Victor-Felix, Capper, David, Hernáiz Driever, Pablo, Gnekow, Astrid, Pfister, Stefan M., Witt, Olaf, Milde, Till

“…Introduction A hallmark of pediatric low-grade glioma (pLGG) is aberrant signaling of the mitogen activated protein kinase (MAPK) pathway. Hence, inhibition of…”
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Primary mismatch repair deficient IDH-mutant astrocytoma (PMMRDIA) is a distinct type with a poor prognosis by Suwala, Abigail K., Stichel, Damian, Schrimpf, Daniel, Kloor, Matthias, Wefers, Annika K., Reinhardt, Annekathrin, Maas, Sybren L. N., Kratz, Christian P., Schweizer, Leonille, Hasselblatt, Martin, Snuderl, Matija, Abedalthagafi, Malak Sameer J., Abdullaev, Zied, Monoranu, Camelia M., Bergmann, Markus, Pekrun, Arnulf, Freyschlag, Christian, Aronica, Eleonora, Kramm, Christof M., Hinz, Felix, Sievers, Philipp, Korshunov, Andrey, Kool, Marcel, Pfister, Stefan M., Sturm, Dominik, Jones, David T. W., Wick, Wolfgang, Unterberg, Andreas, Hartmann, Christian, Dodgshun, Andrew, Tabori, Uri, Wesseling, Pieter, Sahm, Felix, von Deimling, Andreas, Reuss, David E.

“…Diffuse IDH-mutant astrocytoma mostly occurs in adults and carries a favorable prognosis compared to IDH-wildtype malignant gliomas. Acquired mismatch repair…”
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AI-Based Forecasting of Polymer Properties for High-Temperature Butyl Acrylate Polymerizations by Fiosina, Jelena, Sievers, Philipp, Drache, Marco, Beuermann, Sabine

“…High-temperature polymerizations involving self-initiation of the monomer are attractive because of high reaction rate, comparable lower viscosities, and no…”
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Rapid-CNS2: rapid comprehensive adaptive nanopore-sequencing of CNS tumors, a proof-of-concept study by Patel, Areeba, Dogan, Helin, Payne, Alexander, Krause, Elena, Sievers, Philipp, Schoebe, Natalie, Schrimpf, Daniel, Blume, Christina, Stichel, Damian, Holmes, Nadine, Euskirchen, Philipp, Hench, Jürgen, Frank, Stephan, Rosenstiel-Goidts, Violaine, Ratliff, Miriam, Etminan, Nima, Unterberg, Andreas, Dieterich, Christoph, Herold-Mende, Christel, Pfister, Stefan M., Wick, Wolfgang, Loose, Matthew, von Deimling, Andreas, Sill, Martin, Jones, David T. W., Schlesner, Matthias, Sahm, Felix

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Molecular profiling of pediatric meningiomas shows tumor characteristics distinct from adult meningiomas by Kirches, Elmar, Sahm, Felix, Korshunov, Andrey, Bluecher, Christina, Waldt, Natalie, Kropf, Siegfried, Schrimpf, Daniel, Sievers, Philipp, Stichel, Damian, Schüller, Ulrich, Schittenhelm, Jens, Riemenschneider, Markus J., Karajannis, Matthias A., Perry, Arie, Pietsch, Torsten, Boekhoff, Svenja, Capper, David, Beck, Katja, Paramasivam, Nagarajan, Schlesner, Matthias, Brastianos, Priscilla K., Müller, Hermann L., Pfister, Stefan M., Mawrin, Christian

“…In contrast to adults, meningiomas are uncommon tumors in childhood and adolescence. Whether adult and pediatric meningiomas differ on a molecular level is…”
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A clinically applicable connectivity signature for glioblastoma includes the tumor network driver CHI3L1 by Hai, Ling, Hoffmann, Dirk C., Wagener, Robin J., Azorin, Daniel D., Hausmann, David, Xie, Ruifan, Huppertz, Magnus-Carsten, Hiblot, Julien, Sievers, Philipp, Heuer, Sophie, Ito, Jakob, Cebulla, Gina, Kourtesakis, Alexandros, Kaulen, Leon D., Ratliff, Miriam, Mandelbaum, Henriette, Jung, Erik, Jabali, Ammar, Horschitz, Sandra, Ernst, Kati J., Reibold, Denise, Warnken, Uwe, Venkataramani, Varun, Will, Rainer, Suvà, Mario L., Herold-Mende, Christel, Sahm, Felix, Winkler, Frank, Schlesner, Matthias, Wick, Wolfgang, Kessler, Tobias

“…Tumor microtubes (TMs) connect glioma cells to a network with considerable relevance for tumor progression and therapy resistance. However, the determination…”
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Routine RNA sequencing of formalin-fixed paraffin-embedded specimens in neuropathology diagnostics identifies diagnostically and therapeutically relevant gene fusions by Stichel, Damian, Schrimpf, Daniel, Casalini, Belén, Meyer, Jochen, Wefers, Annika K., Sievers, Philipp, Korshunov, Andrey, Koelsche, Christian, Reuss, David E., Reinhardt, Annekathrin, Ebrahimi, Azadeh, Fernández-Klett, Francisco, Kessler, Tobias, Sturm, Dominik, Ecker, Jonas, Milde, Till, Herold-Mende, Christel, Witt, Olaf, Pfister, Stefan M., Wick, Wolfgang, Jones, David T. W., von Deimling, Andreas, Sahm, Felix

“…Molecular markers have become pivotal in brain tumor diagnostics. Mutational analyses by targeted next-generation sequencing of DNA and array-based DNA…”
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GOPC:ROS1 and other ROS1 fusions represent a rare but recurrent drug target in a variety of glioma types by Sievers, Philipp, Stichel, Damian, Sill, Martin, Schrimpf, Daniel, Sturm, Dominik, Selt, Florian, Ecker, Jonas, Kazdal, Daniel, Miele, Evelina, Kranendonk, Mariëtte E. G., Tops, Bastiaan B. J., Kohlhof-Meinecke, Patricia, Beschorner, Rudi, Kramm, Christof M., Hasselblatt, Martin, Reifenberger, Guido, Capper, David, Wesseling, Pieter, Stenzinger, Albrecht, Milde, Till, Korshunov, Andrey, Witt, Olaf, Pfister, Stefan M., Wick, Wolfgang, von Deimling, Andreas, Jones, David T. W., Sahm, Felix

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Posterior fossa pilocytic astrocytomas with oligodendroglial features show frequent FGFR1 activation via fusion or mutation by Sievers, Philipp, Schrimpf, Daniel, Stichel, Damian, Reuss, David E., Hasselblatt, Martin, Hagel, Christian, Staszewski, Ori, Hench, Jürgen, Frank, Stephan, Brandner, Sebastian, Korshunov, Andrey, Wick, Wolfgang, Pfister, Stefan M., Reifenberger, Guido, von Deimling, Andreas, Sahm, Felix, Jones, David T. W.

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Transcriptional profiling of medulloblastoma with extensive nodularity (MBEN) reveals two clinically relevant tumor subsets with VSNL1 as potent prognostic marker by Korshunov, Andrey, Okonechnikov, Konstantin, Sahm, Felix, Ryzhova, Marina, Stichel, Damian, Schrimpf, Daniel, Ghasemi, David R., Pajtler, Kristian W., Antonelli, Manila, Donofrio, Vittoria, Mastronuzzi, Angela, Rossi, Sabrina, Camassei, Francesca Diomedi, Buccoliero, Anna Maria, Haberler, Christine, Slavc, Irene, Dahiya, Sonika, Casalini, Belen, Sievers, Philipp, Meyer, Jochen, Kumirova, Ella, Zheludkova, Olga, Golanov, Andrey, Jones, David T. W., Pfister, Stefan M., Kool, Marcel, von Deimling, Andreas

“…Medulloblastoma with extensive nodularity (MBEN) is one of the few central nervous system (CNS) tumor entities occurring in infants which is traditionally…”
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A multi-institutional series of a novel, recurrent TRIM24::MET fusion-driven infant-type hemispheric glioma reveals significant clinico-pathological heterogeneity by Gorodezki, David, Chiang, Jason, Viaene, Angela N, Sievers, Philipp, Schmid, Simone, Holzer, Ursula, Paulsen, Frank, Schuhmann, Martin U, Witt, Olaf, Schittenhelm, Jens, Ebinger, Martin

“…Within the past decade, incremental integration of molecular characteristics into the classification of central nervous system neoplasms increasingly…”
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Comparison of transcriptome profiles between medulloblastoma primary and recurrent tumors uncovers novel variance effects in relapses by Okonechnikov, Konstantin, Federico, Aniello, Schrimpf, Daniel, Sievers, Philipp, Sahm, Felix, Koster, Jan, Jones, David T W, von Deimling, Andreas, Pfister, Stefan M, Kool, Marcel, Korshunov, Andrey

“…Nowadays medulloblastoma (MB) tumors can be treated with risk-stratified approaches with up to 80% success rate. However, disease relapses occur in…”
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Refinement of diagnostic criteria for pediatric-type diffuse high-grade glioma, IDH- and H3-wildtype, MYCN-subtype including histopathology, TP53, MYCN and ID2 status by Tauziède-Espariat, Arnault, Uro-Coste, Emmanuelle, Nicaise, Yvan, Sievers, Philipp, von Deimling, Andreas, Sahm, Felix, Aboubakr, Oumaima, Métais, Alice, Chrétien, Fabrice, Varlet, Pascale

“…Because a subset of pHGG-MYCN have been found to harbor an amplification of the ID2 gene with (12/36, 33%) or without (1/36, 3%) a concomitant MYCN…”
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Diagnostic accuracy of a minimal immunohistochemical panel in at/rt molecular subtyping, correlated to dna-methylation profiling by Tauziède-Espariat, Arnault, Masliah-Planchon, Julien, Andrianteranagna, Mamy, Sievers, Philipp, Sahm, Felix, von Deimling, Andreas, Hasty, Lauren, Delattre, Olivier, Beccaria, Kévin, Métais, Alice, Chrétien, Fabrice, Varlet, Pascale, Bourdeaut, Franck

“…Keywords: AT/RT, DNA-methylation profiling, TYR, SHH, MYC, Immunohistochemistry…”
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Molecular analysis of pediatric CNS-PNET revealed nosologic heterogeneity and potent diagnostic markers for CNS neuroblastoma with FOXR2-activation by Korshunov, Andrey, Okonechnikov, Konstantin, Schmitt-Hoffner, Felix, Ryzhova, Marina, Sahm, Felix, Stichel, Damian, Schrimpf, Daniel, Reuss, David E, Sievers, Philipp, Suwala, Abigail Kora, Kumirova, Ella, Zheludkova, Olga, Golanov, Andrey, Jones, David T W, Pfister, Stefan M, Kool, Marcel, von Deimling, Andreas

“…Primitive neuroectodermal tumors of the central nervous system (CNS-PNETs) are highly malignant neoplasms posing diagnostic challenge due to a lack of defining…”
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Pediatric high-grade glioma MYCN is frequently associated with Li-Fraumeni syndrome by Guerrini-Rousseau, Léa, Tauziède-Espariat, Arnault, Castel, David, Rouleau, Etienne, Sievers, Philipp, Saffroy, Raphaël, Beccaria, Kévin, Blauwblomme, Thomas, Hasty, Lauren, Bourdeaut, Franck, Grill, Jacques, Varlet, Pascale, Debily, Marie-Anne

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CNS neuroblastoma, FOXR2-activated and its mimics: a relevant panel approach for work-up and accurate diagnosis of this rare neoplasm by Tauziède-Espariat, Arnault, Figarella-Branger, Dominique, Métais, Alice, Uro-Coste, Emmanuelle, Maurage, Claude-Alain, Lhermitte, Benoît, Aline-Fardin, Aude, Hasty, Lauren, Vasiljevic, Alexandre, Chiforeanu, Dan, Chotard, Guillaume, Adle-Biassette, Homa, Meurgey, Alexandra, Saffroy, Raphaël, Guillemot, Delphine, Pierron, Gaëlle, Sievers, Philipp, Varlet, Pascale

“…[...]the diagnosis is confirmed using advanced molecular techniques (Next-generation sequencing or DNA-methylation profiling) [3]. [...]10/24 cases were…”
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