Search Results - "Sievers, A."

Molecular basis for insulin fibril assembly by Ivanova, Magdalena I, Sievers, Stuart A, Sawaya, Michael R, Wall, Joseph S, Eisenberg, David

“…In the rare medical condition termed injection amyloidosis, extracellular fibrils of insulin are observed. We found that the segment of the insulin B-chain…”
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Structure-based design of non-natural amino-acid inhibitors of amyloid fibril formation by Sievers, Stuart A., Karanicolas, John, Chang, Howard W., Zhao, Anni, Jiang, Lin, Zirafi, Onofrio, Stevens, Jason T., Münch, Jan, Baker, David, Eisenberg, David

“…Anti-amyloid drug design Amyloid diseases such as Alzheimer's are associated with the transformation of normally soluble proteins into amyloid fibrils —…”
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F-GAMMA: variability Doppler factors of blazars from multiwavelength monitoring by Liodakis, I., Marchili, N., Angelakis, E., Fuhrmann, L., Nestoras, I., Myserlis, I., Karamanavis, V., Krichbaum, T. P., Sievers, A., Ungerechts, H., Zensus, J. A.

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Direct observation of the discrete character of intrinsic localized modes in an antiferromagnet by Sievers, A. J, Sato, M

“…In a strongly nonlinear discrete system, the spatial size of an excitation can become comparable to, and influenced by, the lattice spacing. Such intrinsic…”
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Towards a pharmacophore for amyloid by Landau, Meytal, Sawaya, Michael R, Faull, Kym F, Laganowsky, Arthur, Jiang, Lin, Sievers, Stuart A, Liu, Jie, Barrio, Jorge R, Eisenberg, David

“…Diagnosing and treating Alzheimer's and other diseases associated with amyloid fibers remains a great challenge despite intensive research. To aid in this…”
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Aggregation-triggering segments of SOD1 fibril formation support a common pathway for familial and sporadic ALS by Ivanova, Magdalena I., Sievers, Stuart A., Guenther, Elizabeth L., Johnson, Lisa M., Winkler, Duane D., Galaleldeen, Ahmad, Sawaya, Michael R., Hart, John, Eisenberg, David S.

“…ALS is a terminal disease of motor neurons that is characterized by accumulation of proteinaceous deposits in affected cells. Pathological deposition of…”
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Colloquium : Nonlinear energy localization and its manipulation in micromechanical oscillator arrays by Sato, M., Hubbard, B. E., Sievers, A. J.

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The 3D Profile Method for Identifying Fibril-Forming Segments of Proteins by Thompson, Michael J., Sievers, Stuart A., Karanicolas, John, Ivanova, Magdalena I., Baker, David, Eisenberg, David

“…Based on the crystal structure of the cross-β spine formed by the peptide NNQQNY, we have developed a computational approach for identifying those segments of…”
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Atomic structures of IAPP (amylin) fusions suggest a mechanism for fibrillation and the role of insulin in the process by Wiltzius, Jed J. W., Sievers, Stuart A., Sawaya, Michael R., Eisenberg, David

“…Islet Amyloid Polypeptide (IAPP or amylin) is a peptide hormone produced and stored in the β‐islet cells of the pancreas along with insulin. IAPP readily forms…”
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Experimental observations of nonlinear vibration localization in a cyclic chain of weakly coupled nonlinear oscillators by Niedergesäß, B., Papangelo, A., Grolet, A., Vizzaccaro, A., Fontanela, F., Salles, L., Sievers, A.J., Hoffmann, N.

“…Experimental results on nonlinear vibration localization in a cyclic chain of weakly coupled oscillators with clearance nonlinearity are reported. Numerical…”
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Thermally populated intrinsic localized modes in pure alkali halide crystals by Sievers, A. J., Sato, M., Page, J. B., Rössler, T.

“…The possibility of thermal excitation of intrinsic localized modes (ILMs) arising from anharmonicity in ionic perfect crystals is studied numerically for…”
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The effects of physical and chemical preprocessing on the flowability of corn stover by Crawford, Nathan C., Nagle, Nick, Sievers, David A., Stickel, Jonathan J.

“…Continuous and reliable feeding of biomass is essential for successful biofuel production. However, the challenges associated with biomass solids handling are…”
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Crystal structures of amyloidogenic segments of human transthyretin by Saelices, Lorena, Sievers, Stuart A., Sawaya, Michael R., Eisenberg, David S.

“…Amyloid diseases are characterized by the deposition of proteins in the form of amyloid fibrils, in organs that eventually fail. The development of effective…”
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Experimentally observed evolution between dynamic patterns and intrinsic localized modes in a driven nonlinear electrical cyclic lattice by Shige, S., Miyasaka, K., Shi, W., Soga, Y., Sato, M., Sievers, A. J.

“…Locked intrinsic localized modes (ILMs) and large amplitude lattice spatial modes (LSMs) have been experimentally measured for a driven 1-D nonlinear cyclic…”
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GASTON: Galactic Star Formation with NIKA2 – evidence for the mass growth of star-forming clumps by Rigby, A J, Peretto, N, Adam, R, Ade, P, Anderson, M, André, P, Andrianasolo, A, Aussel, H, Bacmann, A, Beelen, A, Benoît, A, Berta, S, Bourrion, O, Bracco, A, Calvo, M, Catalano, A, De Petris, M, Désert, F-X, Doyle, S, Driessen, E F C, García, P, Gomez, A, Goupy, J, Kéruzoré, F, Kramer, C, Ladjelate, B, Lagache, G, Leclercq, S, Lestrade, J-F, Macías-Pérez, J F, Mauskopf, P, Mayet, F, Monfardini, A, Perotto, L, Pisano, G, Ponthieu, N, Revéret, V, Ristorcelli, I, Ritacco, A, Romero, C, Roussel, H, Ruppin, F, Schuster, K, Shu, S, Sievers, A, Tucker, C, Watkins, E J

“…ABSTRACT Determining the mechanism by which high-mass stars are formed is essential for our understanding of the energy budget and chemical evolution of…”
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Observation of locked intrinsic localized vibrational modes in a micromechanical oscillator array by Sato, M, Hubbard, B E, Sievers, A J, Ilic, B, Czaplewski, D A, Craighead, H G

“…The nonlinear vibrational properties of a periodic micromechanical oscillator array have been measured. For sufficiently large amplitude of the driver, the…”
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Generation of localized modes in an electrical lattice using subharmonic driving by English, L Q, Palmero, F, Candiani, P, Cuevas, J, Carretero-González, R, Kevrekidis, P G, Sievers, A J

“…We show experimentally and numerically that an intrinsic localized mode (ILM) can be stably produced (and experimentally observed) via subharmonic, spatially…”
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Structural basis for germline antibody recognition of HIV-1 immunogens by Scharf, Louise, West, Anthony P, Sievers, Stuart A, Chen, Courtney, Jiang, Siduo, Gao, Han, Gray, Matthew D, McGuire, Andrew T, Scheid, Johannes F, Nussenzweig, Michel C, Stamatatos, Leonidas, Bjorkman, Pamela J

“…Efforts to elicit broadly neutralizing antibodies (bNAbs) against HIV-1 require understanding germline bNAb recognition of HIV-1 envelope glycoprotein (Env)…”
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Erratum: Experimentally observed evolution between dynamic patterns and intrinsic localized modes in a driven nonlinear electrical cyclic lattice by Shige, S., Miyasaka, K., Shi, W., Soga, Y., Sato, M., Sievers, A. J.

“…Original article: EPL, 121 (2018) 30003…”
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A New Glycan-Dependent CD4-Binding Site Neutralizing Antibody Exerts Pressure on HIV-1 In Vivo by Freund, Natalia T, Horwitz, Joshua A, Nogueira, Lilian, Sievers, Stuart A, Scharf, Louise, Scheid, Johannes F, Gazumyan, Anna, Liu, Cassie, Velinzon, Klara, Goldenthal, Ariel, Sanders, Rogier W, Moore, John P, Bjorkman, Pamela J, Seaman, Michael S, Walker, Bruce D, Klein, Florian, Nussenzweig, Michel C

“…The CD4 binding site (CD4bs) on the envelope glycoprotein is a major site of vulnerability that is conserved among different HIV-1 isolates. Many broadly…”
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