Search Results - "Siesjö, Bo K."

Calcium in ischemic cell death by KRISTIAN, T, SIESJÖ, B. K

“…This review article deals with the role of calcium in ischemic cell death. A calcium-related mechanism was proposed more than two decades ago to explain cell…”
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A Mismatch Between the Abnormalities in Diffusion- and Susceptibility-Weighted Magnetic Resonance Imaging May Represent an Acute Ischemic Penumbra with Misery Perfusion by Fujioka, Masayuki, MD, PhD, Okuchi, Kazuo, MD, Iwamura, Asami, MD, Taoka, Toshiaki, MD, Siesjö, Bo K., MD, PhD

“…Susceptibility-weighted imaging (SWI) has recently attracted attention for its ability to investigate acute stroke pathophysiology. SWI detects an increased…”
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Involvement of Caspase-3 in Cell Death After Hypoxia-Ischemia Declines During Brain Maturation by Hu, Bing R., Liu, Chun Li, Ouyang, Yibing, Blomgren, Klas, Siesjö, Bo K.

“…The involvement of caspase-3 in cell death after hypoxia–ischemia (HI) was studied during brain maturation. Unilateral HI was produced in rats at postnatal day…”
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Magnetic resonance imaging shows delayed ischemic striatal neurodegeneration by Fujioka, Masayuki, Taoka, Toshiaki, Matsuo, Yoshiyuki, Mishima, Kenichi, Ogoshi, Kumiko, Kondo, Yoichi, Tsuda, Masakazu, Fujiwara, Michihiro, Asano, Takao, Sakaki, Toshisuke, Miyasaki, Akihiro, Park, Darren, Siesjö, Bo K.

“…Brief focal ischemia leading to temporary neurological deficits induces delayed hyperintensity on T1‐weighted magnetic resonance imaging (MRI) in the striatum…”
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Hyperglycemia enhances extracellular glutamate accumulation in rats subjected to forebrain ischemia by Li, P A, Shuaib, A, Miyashita, H, He, Q P, Siesjö, B K, Warner, D S

“…An increase in serum glucose at the time of acute ischemia has been shown to adversely affect prognosis. The mechanisms for the hyperglycemia-exacerbated…”
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Protein Aggregation After Focal Brain Ischemia and Reperfusion by Hu, Bing-Ren, Janelidze, Shorena, Ginsberg, Myron D., Busto, Raul, Perez-Pinzon, Miguel, Sick, Thomas J., Siesjö, Bo K., Liu, C. L.

“…Two hours of transient focal brain ischemia causes acute neuronal death in the striatal core region and a somewhat more delayed type of neuronal death in…”
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Acidosis promotes the permeability transition in energized mitochondria: implications for reperfusion injury by Kristian, T, Bernardi, P, Siesjö, B K

“…We have studied the influence of pH on opening of the mitochondrial permeability transition pore (PTP) in both deenergized and energized mitochondria in the…”
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Amelioration by cyclosporin A of brain damage in transient forebrain ischemia in the rat by Uchino, Hiroyuki, Elmér, Eskil, Uchino, Keiko, Li, Ping-An, He, Qing-Ping, Smith, Maj-Lis, Siesjö, Bo K

“…The immunosuppressant drug cyclosporin A (CsA) is considered to be inherently protective in conditions of ischemia, e.g. in hepatic and cardiac tissue…”
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Amelioration by cyclosporin A of brain damage following 5 or 10 min of ischemia in rats subjected to preischemic hyperglycemia by Li, Ping-An, Uchino, Hiroyuki, Elmér, Eskil, Siesjö, Bo K

“…It has recently been shown that the immunosuppressant cyclosporin A (CsA) dramatically ameliorates the selective neuronal necrosis which results from 10 min of…”
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Production of hydroxyl free radical by brain tissues in hyperglycemic rats subjected to transient forebrain ischemia by Li, Ping-An, Liu, Guang-Jun, He, Qing Ping, Floyd, Robert A, Siesjö, Bo K

“…Preischemic hyperglycemia is known to aggravate brain damage resulting from transient ischemia. In the present study, we explored whether this aggravation is…”
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Hyperglycemia and hypercapnia differently affect post-ischemic changes in protein kinases and protein phosphorylation in the rat cingulate cortex by Kurihara, Junichi, Katsura, Ken-ichiro, Siesjö, Bo.K., Wieloch, Tadeusz

“…Hyperglycemia and hypercapnia aggravate intra-ischemic acidosis and subsequent brain damage. However, hyperglycemia causes more extensive post-ischemic damage…”
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Pathophysiology and treatment of focal cerebral ischemia. Part I: Pathophysiology. (1992) by Siesjö, Bo K

“…This article examines the pathophysiology of lesions caused by focal cerebral ischemia. Ischemia due to middle cerebral artery occlusion encompasses a densely…”
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ADAMTS13 gene deletion enhances plasma high-mobility group box1 elevation and neuroinflammation in brain ischemia–reperfusion injury by Fujioka, Masayuki, Nakano, Takafumi, Hayakawa, Kazuhide, Irie, Keiichi, Akitake, Yoshiharu, Sakamoto, Yuya, Mishima, Kenichi, Muroi, Carl, Yonekawa, Yasuhiro, Banno, Fumiaki, Kokame, Koichi, Miyata, Toshiyuki, Nishio, Kenji, Okuchi, Kazuo, Iwasaki, Katsunori, Fujiwara, Michihiro, Siesjö, Bo K.

“…Highly adhesive glycoprotein von Willebrand factor (VWF) multimer induces platelet aggregation and leukocyte tethering or extravasation on the injured vascular…”
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Hyperglycemia Enhances DNA Fragmentation After Transient Cerebral Ischemia by Li, Ping-An, Rasquinha, Ingrid, He, Qing Ping, Siesjö, Bo K., Csiszár, Katalin, Boyd, Charles D., MacManus, John P.

“…Previous histopathologic results have suggested that one mechanism whereby hyperglycemia (HG) leads to exaggerated ischemic damage involves fragmentation of…”
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Differential Neuroprotection by Cyclosporin A and FK506 Following Ischemia Corresponds with Differing Abilities to Inhibit Calcineurin and the Mitochondrial Permeability Transition by Uchino, Hiroyuki, Minamikawa-Tachino, Reiko, Kristián, Tibor, Perkins, Guy, Narazaki, Michiko, Siesjö, Bo K., Shibasaki, Futoshi

“…Transient global or forebrain ischemia leads to severe brain damage following delayed neuronal cell death. We previously reported that cyclosporin A (CsA)…”
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Effects of intracarotid arterial injection of cyclosporin A and spontaneous hypothermia on brain damage incurred after a long period of global ischemia by Li, Ping-An, He, Qing Ping, Siesjö, Bo K.

“…A recent study showed that a single intracarotid arterial injection of cyclosporin A (CsA) can dramatically reduce infarct volume in rats subjected to…”
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Posttreatment with the immunosuppressant cyclosporin A in transient focal ischemia by Yoshimoto, Tetsuyuki, Siesjö, Bo K

“…Cyclosporin A (CsA) reduces ischemic brain damage when administered in such a way that its penetration across the blood–brain barrier is enhanced. Since only…”
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Neuroprotective Effects of a Novel Nitrone, NXY-059, After Transient Focal Cerebral Ischemia in the Rat by Kuroda, Satoshi, Tsuchidate, Ryoichi, Smith, Maj-Lis, Maples, Kirk R., Siesjö, Bo K.

“…Recent results have demonstrated that the spin trapping agent α-phenyl-N-tert-butyl nitrone (PBN) reduces infarct volume in rats subjected to 2 hours of middle…”
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Differential phosphorylation at Ser473 and Thr308 of Akt-1 in rat brain following hypoglycemic coma by Ouyang, Yi-Bing, Zhang, Xiao-Hu, He, Qing-Ping, Wang, Gui-Xia, Siesjö, Bo K, Hu, Bing-Ren

“…We analyzed both total Akt-1 and phosphorylation of Akt-1 at residues Ser473 and Thr308 (phospho-Akt-1 Ser474 and phospho-Akt-1 Thr308, respectively) in the…”
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Survival- and Death-Promoting Events After Transient Cerebral Ischemia: Phosphorylation of Akt, Release of Cytochrome C, and Activation of Caspase-Like Proteases by Ouyang, Yi-Bing, Tan, Ying, Comb, M., Liu, Chun-Li, Martone, M. E., Siesjö, Bo K., Hu, Bing-Ren

“…Release of cytochrome c (cyt c) into cytoplasm initiates caspase-mediated apoptosis, whereas activation of Akt kinase by phosphorylation at serine-473 prevents…”
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