Search Results - "Sierts, Jeroen A."

Genetic Variant of the Scavenger Receptor BI in Humans by Vergeer, Menno, Korporaal, Suzanne J.A, Franssen, Remco, Meurs, Illiana, Out, Ruud, Hovingh, G. Kees, Hoekstra, Menno, Sierts, Jeroen A, Dallinga-Thie, Geesje M, Motazacker, Mohammad Mahdi, Holleboom, Adriaan G, Van Berkel, Theo J.C, Kastelein, John J.P, Van Eck, Miranda, Kuivenhoven, Jan Albert

“…In a family with high HDL, a genetic mutation was identified. In addition to higher HDL levels, carriers had reduced cholesterol efflux from macrophages,…”
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Heterozygosity for a Loss-of-Function Mutation in GALNT2 Improves Plasma Triglyceride Clearance in Man by Holleboom, Adriaan G., Karlsson, Helen, Lin, Ruei-Shiuan, Beres, Thomas M., Sierts, Jeroen A., Herman, Daniel S., Stroes, Erik S.G., Aerts, Johannes M., Kastelein, John J.P., Motazacker, Mohammad M., Dallinga-Thie, Geesje M., Levels, Johannes H.M., Zwinderman, Aeilko H., Seidman, Jonathan G., Seidman, Christine E., Ljunggren, Stefan, Lefeber, Dirk J., Morava, Eva, Wevers, Ron A., Fritz, Timothy A., Tabak, Lawrence A., Lindahl, Mats, Hovingh, G. Kees, Kuivenhoven, Jan Albert

“…Genome-wide association studies have identified GALNT2 as a candidate gene in lipid metabolism, but it is not known how the encoded enzyme ppGalNAc-T2, which…”
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AAV gene therapy as a means to increase apolipoprotein (Apo) A-I and high-density lipoprotein-cholesterol levels: correction of murine ApoA-I deficiency by Vaessen, Stefan F. C., Veldman, Robert Jan, Comijn, Elisabeth M., Snapper, Jolanda, Sierts, Jeroen A., van den Oever, Karin, Beattie, Stuart G., Twisk, Jaap, Kuivenhoven, Jan Albert

“…Background Inherited apolipoprotein (Apo) A‐I deficiency is an orphan disorder characterized by high‐density lipoprotein (HDL)‐cholesterol deficiency and…”
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Gene therapy for lipoprotein lipase deficiency: working toward clinical application by Rip, Jaap, Nierman, Melchior C, Sierts, Jeroen A, Petersen, Wilma, Van den Oever, Karin, Van Raalte, Daniel, Ross, Colin J D, Hayden, Michael R, Bakker, Andrew C, Dijkhuizen, Paul, Hermens, Wim T, Twisk, Jaap, Stroes, Erik, Kastelein, John J P, Kuivenhoven, Jan Albert, Meulenberg, Janneke M

“…Lipoprotein lipase (LPL) deficiency causes hypertriglyceridemia and recurrent, potentially life-threatening pancreatitis. There currently is no adequate…”
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Lipoprotein profiles in human heterozygote carriers of a functional mutation P297S in scavenger receptor class B1 by Ljunggren, Stefan A., Levels, Johannes H.M., Hovingh, Kees, Holleboom, Adriaan G., Vergeer, Menno, Argyri, Letta, Gkolfinopoulou, Christina, Chroni, Angeliki, Sierts, Jeroen A., Kastelein, John J., Kuivenhoven, Jan Albert, Lindahl, Mats, Karlsson, Helen

“…The scavenger receptor class B type 1 (SR-B1) is an important HDL receptor involved in cholesterol uptake and efflux, but its physiological role in human…”
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Chylomicronemia With Low Postheparin Lipoprotein Lipase Levels in the Setting of GPIHBP1 Defects by Franssen, Remco, Young, Stephen G, Peelman, Frank, Hertecant, Jozef, Sierts, Jeroen A, Schimmel, Alinda W.M, Bensadoun, André, Kastelein, John J.P, Fong, Loren G, Dallinga-Thie, Geesje M, Beigneux, Anne P

“…BACKGROUND—Recent studies in mice have established that an endothelial cell protein, glycosylphosphatidylinositol-anchored high-density lipoprotein-binding…”
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Efficient lowering of triglyceride levels in mice by human apoAV protein variants associated with hypertriglyceridemia by Vaessen, Stefan F.C., Sierts, Jeroen A., Kuivenhoven, Jan Albert, Schaap, Frank G.

“…Variation in the apolipoprotein A5 (APOA5) gene has consistently been associated with increased plasma triglyceride (TG) levels in epidemiological studies. In…”
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Adeno-associated virus LPL(S447X) gene therapy in LDL receptor knockout mice by Rip, Jaap, Sierts, Jeroen A, Vaessen, Stefan F C, Kastelein, John J P, Twisk, Jaap, Kuivenhoven, Jan Albert

“…Overexpression of lipoprotein lipase (LPL) protects against atherosclerosis in genetically engineered mice. We tested whether a gene therapy vector that…”
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AAV1-LPL(S447X) gene therapy reduces hypertriglyceridemia in apoE2 knock in mice by Rip, Jaap, van Dijk, Ko Willems, Sierts, Jeroen A, Kastelein, John J P, Twisk, Jaap, Kuivenhoven, Jan Albert

“…Intramuscular (IM) application of adeno-associated virus serotype 1 (AAV1) for the delivery of human lipoprotein lipase (hLPL) was previously shown efficacious…”
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Adeno-associated virus LPLS447X gene therapy in LDL receptor knockout mice by Rip, Jaap, Sierts, Jeroen A, Vaessen, Stefan F.C, Kastelein, John J.P, Twisk, Jaap, Kuivenhoven, Jan Albert

“…Abstract Background Overexpression of lipoprotein lipase (LPL) protects against atherosclerosis in genetically engineered mice. We tested whether a gene…”
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Adeno-associated virus LPL S447X gene therapy in LDL receptor knockout mice by Rip, Jaap, Sierts, Jeroen A., Vaessen, Stefan F.C., Kastelein, John J.P., Twisk, Jaap, Kuivenhoven, Jan Albert

“…Overexpression of lipoprotein lipase (LPL) protects against atherosclerosis in genetically engineered mice. We tested whether a gene therapy vector that…”
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AAV1-LPLS447X gene therapy reduces hypertriglyceridemia in apoE2 knock in mice by Rip, Jaap, van Dijk, Ko Willems, Sierts, Jeroen A., Kastelein, John J.P., Twisk, Jaap, Kuivenhoven, Jan Albert

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AAV1-LPL S447X gene therapy reduces hypertriglyceridemia in apoE2 knock in mice by Rip, Jaap, van Dijk, Ko Willems, Sierts, Jeroen A., Kastelein, John J.P., Twisk, Jaap, Kuivenhoven, Jan Albert

“…Intramuscular (IM) application of adeno-associated virus serotype 1 (AAV1) for the delivery of human lipoprotein lipase (hLPL) was previously shown efficacious…”
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907. Gene Therapy for Genetic Lipoprotein Lipase (LPL) Deficiency; an Update by Rip, Jaap, Nierman, Melchior C, Sierts, Jeroen A, Ross, Colin J, Hayden, Michael R, De Jong, Albertine, Dijkhuizen, Paul, Hermens, Wim, Twisk, Jaap, Kastelein, John J, Kuivenhoven, Jan Albert, Meulenberg, Janneke M

“…Lipoprotein lipase (LPL) deficiency cannot be effectively treated and causes severe hypertriglyceridemia and pancreatitis. We have reported that…”
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