Occupational exposure to pesticides dysregulates systemic Th1/Th2/Th17 cytokines and correlates with poor clinical outcomes in breast cancer patients

Pesticides are compounds known to cause immunetoxicity in exposed individuals, which have a potential to substantially modify the prognosis of pathologies dependent on an efficient immune response, such as breast cancer. In this context, we examined the circulating cytokine profile of Th1/Th2/Th17 p...

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Bibliographic Details
Published in:	Frontiers in immunology Vol. 14; p. 1281056
Main Authors:	Santos, Stephany Bonin Godinho dos, da Silva, Janaína Carla, Jaques, Hellen dos Santos, Dalla Vecchia, Marina Ferronato, Ferreira, Mariane Okamoto, Rech, Daniel, Sierota da Silva, Matheus Ryan Noah, Santos, Roberta Bonin Godinho dos, Panis, Carolina, Benvegnú, Dalila Moter
Format:	Journal Article
Language:	English
Published:	Frontiers Media S.A 24-10-2023
Subjects:	breast cancer cytokines dysregulation immune response Immunology prognosis
Online Access:	Get full text
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Summary:	Pesticides are compounds known to cause immunetoxicity in exposed individuals, which have a potential to substantially modify the prognosis of pathologies dependent on an efficient immune response, such as breast cancer. In this context, we examined the circulating cytokine profile of Th1/Th2/Th17 patterns in women occupationally exposed to pesticides and their correlation with worse prognostic outcomes. Peripheral blood samples were collected from 187 rural working women with breast cancer, occupationally exposed or not to pesticides, to quantify the levels of cytokines IL-1β, IL-12, IL-4, IL-17-A, and TNF -α. Data on the disease profile and clinical outcomes were collected through medical follow-up. IL-12 was reduced in exposed women with tumors larger than 2 cm and in those with lymph node metastases. Significantly reduced levels of IL-17A were observed in exposed patients with Luminal B subtype tumors, with high ki67 proliferation rates, high histological grade, and positive for the progesterone receptor. Reduced IL-4 was also seen in exposed women with lymph node invasion. Our data show that occupational exposure to pesticides induces significant changes in the levels of cytokines necessary for tumor control and correlates with poor prognosis clinical outcomes in breast cancer.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 These authors have contributed equally to this work Reviewed by: Kranthi Kiran Kishore Tanagala, Columbia University, United States; Paramita Pal, Takeda, United States; Shashikala Sasidharan, The State University of New Jersey, United States Edited by: Chitra Thakur, Stony Brook University, United States
ISSN:	1664-3224 1664-3224
DOI:	10.3389/fimmu.2023.1281056