Search Results - "Siernicka, Marta"

FOXO1 promotes resistance of non-Hodgkin lymphomas to anti-CD20-based therapy by Pyrzynska, Beata, Dwojak, Michal, Zerrouqi, Abdessamad, Morlino, Giulia, Zapala, Piotr, Miazek, Nina, Zagozdzon, Agnieszka, Bojarczuk, Kamil, Bobrowicz, Malgorzata, Siernicka, Marta, Machnicki, Marcin M., Gobessi, Stefania, Barankiewicz, Joanna, Lech-Maranda, Ewa, Efremov, Dimitar G., Juszczynski, Przemyslaw, Calado, Dinis, Golab, Jakub, Winiarska, Magdalena

“…Diminished overall survival rate of non-Hodgkin lymphoma (NHL) patients treated with a combination regimen of rituximab, cyclophosphamide, doxorubicin,…”
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Synergistic antitumor effects of histone deacetylase inhibitor scriptaid and bortezomib against ovarian cancer cells by Janyst, Karolina, Janyst, Michał, Siernicka, Marta, Lasek, Witold

“…Despite debulking surgery and good initial response to chemotherapy, the majority of patients with advanced ovarian cancer relapse and succumb to their…”
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New insights into redox homeostasis as a therapeutic target in B-cell malignancies by Graczyk-Jarzynka, Agnieszka, Zagozdzon, Radoslaw, Muchowicz, Angelika, Siernicka, Marta, Firczuk, Malgorzata, Juszczynski, Przemyslaw

“…PURPOSE OF REVIEWThe goal of this review is to summarize recent advances in our understanding of the regulation of redox homeostasis and the subtype-specific…”
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Targeting peroxiredoxin 1 impairs growth of breast cancer cells and potently sensitises these cells to prooxidant agents by Bajor, Malgorzata, Zych, Agata O., Graczyk-Jarzynka, Agnieszka, Muchowicz, Angelika, Firczuk, Malgorzata, Trzeciak, Lech, Gaj, Pawel, Domagala, Antoni, Siernicka, Marta, Zagozdzon, Agnieszka, Siedlecki, Pawel, Kniotek, Monika, O’Leary, Patrick C., Golab, Jakub, Zagozdzon, Radoslaw

“…ABSTRACT Background Our previous work has shown peroxiredoxin-1 (PRDX1), one of major antioxidant enzymes, to be a biomarker in human breast cancer. Hereby, we…”
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Dasatinib Effect on NK Cells and Anti-Tumor Immunity by Lachota, Mieszko, Siernicka, Marta, Pilch, Zofia, Graczyk-Jarzynka, Agnieszka, Winiarska, Magdalena

“…Introduction Dasatinib is a potent small molecule kinase inhibitor targeting BCR-ABL kinase - oncogenic driver in Philadelphia chromosome-positive (Ph+) cases…”
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HDAC6 inhibition upregulates CD20 levels and increases the efficacy of anti-CD20 monoclonal antibodies by Bobrowicz, Malgorzata, Dwojak, Michal, Pyrzynska, Beata, Stachura, Joanna, Muchowicz, Angelika, Berthel, Elise, Dalla-Venezia, Nicole, Kozikowski, Mieszko, Siernicka, Marta, Miazek, Nina, Zapala, Piotr, Domagala, Antoni, Bojarczuk, Kamil, Malenda, Agata, Barankiewicz, Joanna, Graczyk-Jarzynka, Agnieszka, Zagozdzon, Agnieszka, Gabrysiak, Magdalena, Diaz, Jean-Jacques, Karp, Marta, Lech-Maranda, Ewa, Firczuk, Malgorzata, Giannopoulos, Krzysztof, Efremov, Dimitar G., Laurenti, Luca, Baatout, Dunja, Frenzel, Lukas, Malinowska, Agata, Slabicki, Mikolaj, Zenz, Thorsten, Zerrouqi, Abdessamad, Golab, Jakub, Winiarska, Magdalena

“…Downregulation of CD20, a molecular target for monoclonal antibodies (mAbs), is a clinical problem leading to decreased efficacy of anti-CD20-based therapeutic…”
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B-cell receptor signaling in the pathogenesis of lymphoid malignancies by Bojarczuk, Kamil, Bobrowicz, Malgorzata, Dwojak, Michal, Miazek, Nina, Zapala, Piotr, Bunes, Anders, Siernicka, Marta, Rozanska, Maria, Winiarska, Magdalena

“…B-cell receptor (BCR) signaling pathway plays a central role in B-lymphocyte development and initiation of humoral immunity. Recently, BCR signaling pathway…”
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Intrinsic Functional Potential of NK-Cell Subsets Constrains Retargeting Driven by Chimeric Antigen Receptors by Oei, Vincent Yi Sheng, Siernicka, Marta, Graczyk-Jarzynka, Agnieszka, Hoel, Hanna Julie, Yang, Weiwen, Palacios, Daniel, Almåsbak, Hilde, Bajor, Malgorzata, Clement, Dennis, Brandt, Ludwig, Önfelt, Björn, Goodridge, Jodie, Winiarska, Magdalena, Zagozdzon, Radoslaw, Olweus, Johanna, Kyte, Jon-Amund, Malmberg, Karl-Johan

“…Natural killer (NK) cells hold potential as a source of allogeneic cytotoxic effector cells for chimeric antigen receptor (CAR)-mediated therapies. Here, we…”
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Adenanthin, a new inhibitor of thiol‐dependent antioxidant enzymes, impairs the effector functions of human natural killer cells by Siernicka, Marta, Winiarska, Magdalena, Bajor, Malgorzata, Firczuk, Malgorzata, Muchowicz, Angelika, Bobrowicz, Malgorzata, Fauriat, Cyril, Golab, Jakub, Olive, Daniel, Zagozdzon, Radoslaw

“…Summary Natural killer (NK) cells are considered critical components of the innate and adaptive immune responses. Deficiencies in NK cell activity are common,…”
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Lysosomal Disruption Augments Obinutuzumab-Induced Direct Cell Death by Domagala, Antoni, Bobrowicz, Malgorzata, Stachura, Joanna, Siernicka, Marta, Mrowka, Piotr, Dwojak, Michal, Pyrzynska, Beata, Firczuk, Malgorzata, Winiarska, Magdalena

“…Anti-CD20 mononclonal antibodies (mAbs) have a well-established role in the treatment of B-cell lymphoid malignancies. In addition to classic Fc-dependent…”
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Influence of Btk Inhibitors on Antitumor Activity of Natural Killer Cells by Siernicka, Marta, Bojarczuk, Kamil, Bobrowicz, Malgorzata, Dwojak, Michal, Pyrzynska, Beata, Olive, Daniel, Winiarska, Magdalena

“…Small molecule Bruton’s tyrosine kinase (Btk) inhibitors are extensively studied in preclinical investigations and clinical trials in the treatment of…”
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HDAC6 Inhibition Increases Translation of CD20 mRNA and Potentiates the Efficacy of Anti-CD20 Immunotherapy by Bobrowicz, Malgorzata, Stachura, Joanna, Dwojak, Michal, Domagala, Antoni, Pyrzynska, Beata, Berthel, Elise, Dalla Venezia, Nicole, Siernicka, Marta, Firczuk, Malgorzata, Winiarska, Magdalena

“…Down-regulation of CD20, a molecular target for monoclonal antibodies, is a clinical problem leading to decreased efficacy of anti-CD20-based regimens…”
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Abstract LB-242: PTEN regulates the CD20 antigen expression and affects rituximab-based therapy of lymphoma malignancies by Pyrzynska, Beata, Bojarczuk, Kamil, Siernicka, Marta, Dwojak, Michal, Bobrowicz, Malgorzata, Miazek, Nina, Zapala, Piotr, Zagozdzon, Agnieszka, Golab, Jakub, Winiarska, Magdalena

“…Abstract The therapeutic strategies currently used in B cell malignancies include the treatment with monoclonal antibodies (rituximab and ofatumumab) directed…”
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HDAC Inhibitors As Potential New Agents Improving the Efficacy of Monoclonal Antibodies by Bobrowicz, Malgorzata, Dwojak, Michal, Malenda, Agata, Bojarczuk, Kamil, Siernicka, Marta, Pyrzynska, Beata, Lech-Maranda, Ewa, Stoklosa, Tomasz, Winiarska, Magdalena, Golab, Jakub

“…HDAC (histone deacetylase) inhibitors belong to a novel class of antitumor agents widely explored in hematology. So far two of them - romidepsin and vorinostat…”
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Inhibitors Of Src Family and AKT Regulate The Activity Of CD20 Promoter by Pyrzynska, Beata, Bojarczuk, Kamil, Winiarska, Magdalena, Bil, Jacek, Miazek, Nina, Zapala, Piotr, Bobrowicz, Malgorzata, Dwojak, Michal, Siernicka, Marta, Golab, Jakub

“…The monoclonal antibodies against CD20 antigen (rituximab and ofatumumab) have been developed and used in a clinic as a therapeutic strategy in B-cell…”
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Inhibitors of SRC kinases impair antitumor activity of anti-CD20 monoclonal antibodies by Winiarska, Magdalena, Bojarczuk, Kamil, Pyrzynska, Beata, Bil, Jacek, Siernicka, Marta, Dwojak, Michal, Bobrowicz, Malgorzata, Miazek, Nina, Zapala, Piotr, Zagozdzon, Agnieszka, Krol, Magdalena, Syta, Aleksandra, Podszywalow-Bartnicka, Paulina, Pilch, Zofia, Dabrowska-Iwanicka, Anna, Juszczynski, Przemyslaw, Efremov, Dimitar G, Slabicki, Mikolaj, Zenz, Thorsten, Le Roy, Aude, Olive, Daniel, Rygiel, Tomasz P, Leusen, Jeanette H W, Golab, Jakub

“…Clinical trials with SRC family kinases (SFKs) inhibitors used alone or in a combination with anti-CD20 monoclonal antibodies (mAbs) are currently underway in…”
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Inhibitors of SRC kinases impair antitumor activity of anti-CD20 monoclonal antibodies by Winiarska, Magdalena, Bojarczuk, Kamil, Pyrzynska, Beata, Bil, Jacek, Siernicka, Marta, Dwojak, Michal, Bobrowicz, Malgorzata, Miazek, Nina, Zapala, Piotr, Zagozdzon, Agnieszka, Krol, Magdalena, Syta, Aleksandra, Podszywalow-Bartnicka, Paulina, Pilch, Zofia, Dabrowska-Iwanicka, Anna, Juszczynski, Przemyslaw, Efremov, Dimitar G, Slabicki, Mikolaj, Zenz, Thorsten, Roy, Aude Le, Olive, Daniel, Rygiel, Tomasz P, Leusen, Jeanette HW, Golab, Jakub

“…Clinical trials with SRC family kinases (SFKs) inhibitors used alone or in a combination with anti-CD20 monoclonal antibodies (mAbs) are currently underway in…”
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