Search Results - "Sierksma, Annerieke"

Identifying individuals with high risk of Alzheimer’s disease using polygenic risk scores by Leonenko, Ganna, Baker, Emily, Stevenson-Hoare, Joshua, Sierksma, Annerieke, Fiers, Mark, Williams, Julie, de Strooper, Bart, Escott-Price, Valentina

“…Polygenic Risk Scores (PRS) for AD offer unique possibilities for reliable identification of individuals at high and low risk of AD. However, there is little…”
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Alteration of the microRNA network during the progression of Alzheimer's disease by Lau, Pierre, Bossers, Koen, Janky, Rekin's, Salta, Evgenia, Frigerio, Carlo Sala, Barbash, Shahar, Rothman, Roy, Sierksma, Annerieke S. R., Thathiah, Amantha, Greenberg, David, Papadopoulou, Aikaterini S., Achsel, Tilmann, Ayoubi, Torik, Soreq, Hermona, Verhaagen, Joost, Swaab, Dick F., Aerts, Stein, De Strooper, Bart

“…An overview of miRNAs altered in Alzheimer's disease (AD) was established by profiling the hippocampus of a cohort of 41 late‐onset AD (LOAD) patients and 23…”
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Novel Alzheimer risk genes determine the microglia response to amyloid‐β but not to TAU pathology by Sierksma, Annerieke, Lu, Ashley, Mancuso, Renzo, Fattorelli, Nicola, Thrupp, Nicola, Salta, Evgenia, Zoco, Jesus, Blum, David, Buée, Luc, De Strooper, Bart, Fiers, Mark

“…Polygenic risk scores have identified that genetic variants without genome‐wide significance still add to the genetic risk of developing Alzheimer's disease…”
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Behavioral and neurobiological effects of prenatal stress exposure in male and female APPswe/PS1dE9 mice by Sierksma, Annerieke S.R, Prickaerts, Jos, Chouliaras, Leonidas, Rostamian, Somayeh, Delbroek, Lore, Rutten, Bart P.F, Steinbusch, Harry W.M, van den Hove, Daniel L.A

“…Abstract Epidemiological evidence implies a role for chronic stress and stress-related disorders in the etiopathogenesis of sporadic Alzheimer's disease (AD)…”
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miR‐132 loss de‐represses ITPKB and aggravates amyloid and TAU pathology in Alzheimer's brain by Salta, Evgenia, Sierksma, Annerieke, Vanden Eynden, Elke, De Strooper, Bart

“…microRNA‐132 (miR‐132) is involved in prosurvival, anti‐inflammatory and memory‐promoting functions in the nervous system and has been found consistently…”
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From Junk to Function: LncRNAs in CNS Health and Disease by Policarpo, Rafaela, Sierksma, Annerieke, De Strooper, Bart, d’Ydewalle, Constantin

“…Recent advances in RNA sequencing technologies helped to uncover the existence of tens of thousands of long non-coding RNAs (lncRNAs) that arise from the dark…”
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Long-term corticosterone exposure decreases insulin sensitivity and induces depressive-like behaviour in the C57BL/6NCrl mouse by van Donkelaar, Eva L, Vaessen, Koen R D, Pawluski, Jodi L, Sierksma, Annerieke S, Blokland, Arjan, Cañete, Ramón, Steinbusch, Harry W M

“…Chronic stress or long-term administration of glucocorticoids disrupts the hypothalamus-pituitary-adrenal system leading to continuous high levels of…”
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Major depression, cognitive dysfunction and Alzheimer's disease: Is there a link? by Sierksma, Annerieke S.R., van den Hove, Daniel L.A., Steinbusch, Harry W.M., Prickaerts, Jos

“…Major depression (MD) is a severe mental disorder characterized by alterations in mood and cognition, with disease severity correlating inversely with…”
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Deregulation of neuronal miRNAs induced by amyloid-β or TAU pathology by Sierksma, Annerieke, Lu, Ashley, Salta, Evgenia, Vanden Eynden, Elke, Callaerts-Vegh, Zsuzsanna, D'Hooge, Rudi, Blum, David, Buée, Luc, Fiers, Mark, De Strooper, Bart

“…Despite diverging levels of amyloid-β (Aβ) and TAU pathology, different mouse models, as well as sporadic AD patients show predictable patterns of episodic…”
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Chronic phosphodiesterase type 2 inhibition improves memory in the APPswe/PS1dE9 mouse model of Alzheimer's disease by Sierksma, Annerieke S.R., Rutten, Kris, Sydlik, Sebastian, Rostamian, Somayeh, Steinbusch, Harry W.M., van den Hove, Daniel L.A., Prickaerts, Jos

“…Alzheimer's disease (AD) is characterized by progressive cognitive deficits and synaptic dysfunction. Over the last decade phosphodiesterase inhibitors (PDEIs)…”
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Targeting EGLN2/PHD1 protects motor neurons and normalizes the astrocytic interferon response by Germeys, Christine, Vandoorne, Tijs, Davie, Kristofer, Poovathingal, Suresh, Heeren, Kara, Vermeire, Wendy, Nami, FatemehArefeh, Moisse, Matthieu, Quaegebeur, Annelies, Sierksma, Annerieke, Rué, Laura, Sicart, Adrià, Eykens, Caroline, De Cock, Lenja, De Strooper, Bart, Carmeliet, Peter, Van Damme, Philip, De Bock, Katrien, Van Den Bosch, Ludo

“…Neuroinflammation and dysregulated energy metabolism are linked to motor neuron degeneration in amyotrophic lateral sclerosis (ALS). The egl-9 family…”
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Effects of prenatal stress exposure on soluble Aβ and brain-derived neurotrophic factor signaling in male and female APPswe/PS1dE9 mice by Sierksma, Annerieke S.R., Vanmierlo, Tim, De Vry, Jochen, Raijmakers, Marjolein E.A., Steinbusch, Harry W.M., van den Hove, Daniel L.A., Prickaerts, Jos

“…Chronic stress and stress-related disorders, such as major depression (MD), have been shown to increase the risk for developing Alzheimer’s disease (AD)…”
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Age-related changes of neuron numbers in the frontal cortex of a transgenic mouse model of Alzheimer’s disease by Lemmens, Marijke A. M., Sierksma, Annerieke S. R., Rutten, Bart P. F., Dennissen, Frank, Steinbusch, Harry W. M., Lucassen, Paul J., Schmitz, Christoph

“…Alzheimer’s disease (AD) is a neurodegenerative disorder, characterized by amyloid plaque accumulation, intracellular tangles and neuronal loss in selective…”
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Fluoxetine Treatment Induces Seizure Behavior and Premature Death in APPswe/PS1dE9 Mice by Sierksma, Annerieke S R, de Nijs, Laurence, Hoogland, Govert, Vanmierlo, Tim, van Leeuwen, Fred W, Rutten, Bart P F, Steinbusch, Harry W M, Prickaerts, Jos, van den Hove, Daniel L A

“…Treatment of Alzheimer's disease (AD) patients with the antidepressant fluoxetine is known to improve memory and cognitive function. However, the mechanisms…”
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microRNA-132 regulates gene expression programs involved in microglial homeostasis by Walgrave, Hannah, Penning, Amber, Tosoni, Giorgia, Snoeck, Sarah, Davie, Kristofer, Davis, Emma, Wolfs, Leen, Sierksma, Annerieke, Mars, Mayte, Bu, Taofeng, Thrupp, Nicola, Zhou, Lujia, Moechars, Diederik, Mancuso, Renzo, Fiers, Mark, Howden, Andrew J.M., De Strooper, Bart, Salta, Evgenia

“…microRNA-132 (miR-132), a known neuronal regulator, is one of the most robustly downregulated microRNAs (miRNAs) in the brain of Alzheimer’s disease (AD)…”
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Translating genetic risk of Alzheimer's disease into mechanistic insight and drug targets by Sierksma, Annerieke, Escott-Price, Valentina, De Strooper, Bart

“…To provide better prevention and treatment, we need to understand the environmental and genetic risks of Alzheimer's disease (AD). However, the definition of…”
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Stem-cell-derived human microglia transplanted in mouse brain to study human disease by Mancuso, Renzo, Van Den Daele, Johanna, Fattorelli, Nicola, Wolfs, Leen, Balusu, Sriram, Burton, Oliver, Liston, Adrian, Sierksma, Annerieke, Fourne, Yannick, Poovathingal, Suresh, Arranz-Mendiguren, Amaia, Sala Frigerio, Carlo, Claes, Christel, Serneels, Lutgarde, Theys, Tom, Perry, V. Hugh, Verfaillie, Catherine, Fiers, Mark, De Strooper, Bart

“…Although genetics highlights the role of microglia in Alzheimer’s disease, one-third of putative Alzheimer’s disease risk genes lack adequate mouse orthologs…”
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MEG3 activates necroptosis in human neuron xenografts modeling Alzheimer’s disease by Balusu, Sriram, Horré, Katrien, Thrupp, Nicola, Craessaerts, Katleen, Snellinx, An, Serneels, Lutgarde, T’Syen, Dries, Chrysidou, Iordana, Arranz, Amaia M., Sierksma, Annerieke, Simrén, Joel, Karikari, Thomas K., Zetterberg, Henrik, Chen, Wei-Ting, Thal, Dietmar Rudolf, Salta, Evgenia, Fiers, Mark, De Strooper, Bart

“…Neuronal cell loss is a defining feature of Alzheimer’s disease (AD), but the underlying mechanisms remain unclear. We xenografted human or mouse neurons into…”
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Alteration of the micro RNA network during the progression of Alzheimer's disease by Lau, Pierre, Bossers, Koen, Janky, Rekin's, Salta, Evgenia, Frigerio, Carlo Sala, Barbash, Shahar, Rothman, Roy, Sierksma, Annerieke S. R., Thathiah, Amantha, Greenberg, David, Papadopoulou, Aikaterini S., Achsel, Tilmann, Ayoubi, Torik, Soreq, Hermona, Verhaagen, Joost, Swaab, Dick F., Aerts, Stein, De Strooper, Bart

“…An overview of miRNAs altered in Alzheimer's disease (AD) was established by profiling the hippocampus of a cohort of 41 late‐onset AD (LOAD) patients and 23…”
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Comparison between touchscreen operant chambers and water maze to detect early prefrontal dysfunction in mice by Van den Broeck, Lore, Sierksma, Annerieke, Hansquine, Pierre, Thonnard, David, Callaerts‐Vegh, Zsuzsanna, D'Hooge, Rudi

“…The relative lack of sensitive and clinically valid tests of rodent behavior might be one of the reasons for the limited success of the clinical translation of…”
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