Search Results - "Sierks, Michael"

A conformation-specific antibody against oligomeric β-amyloid restores neuronal integrity in a mouse model of Alzheimer's disease by He, Ping, Schulz, Philip, Sierks, Michael R.

“…Conformationally distinct aggregates of the amyloid β (Aβ) peptide accumulate in brains of patients with Alzheimer's disease (AD), but the roles of the…”
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Sex-Specific Multiparameter Blood Test for the Early Diagnosis of Alzheimer's Disease by Cho, Hyung Joon, Schulz, Philip, Venkataraman, Lalitha, Caselli, Richard J, Sierks, Michael R

“…Blood-based biomarkers are needed for the early diagnosis of Alzheimer's disease (AD). We analyzed longitudinal human plasma samples from AD and control cases…”
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Oligomeric α-synuclein and β-amyloid variants as potential biomarkers for Parkinson's and Alzheimer's diseases by Williams, Stephanie M., Schulz, Philip, Sierks, Michael R.

“…Oligomeric forms of α‐synuclein and β‐amyloid are toxic protein variants that are thought to contribute to the onset and progression of Parkinson's disease…”
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Curcumin reduces alpha-synuclein induced cytotoxicity in Parkinson's disease cell model by Wang, Min S, Boddapati, Shanta, Emadi, Sharareh, Sierks, Michael R

“…Overexpression and abnormal accumulation of aggregated alpha-synuclein (alphaS) have been linked to Parkinson's disease (PD) and other synucleinopathies…”
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Soluble α-synuclein–antibody complexes activate the NLRP3 inflammasome in hiPSC-derived microglia by Trudler, Dorit, Nazor, Kristopher L., Eisele, Yvonne S., Grabauskas, Titas, Dolatabadi, Nima, Parker, James, Sultan, Abdullah, Zhong, Zhenyu, Goodwin, Marshall S., Levites, Yona, Golde, Todd E., Kelly, Jeffery W., Sierks, Michael R., Schork, Nicholas J., Karin, Michael, Ambasudhan, Rajesh, Lipton, Stuart A.

“…Parkinson’s disease is characterized by accumulation of α-synuclein (αSyn). Release of oligomeric/fibrillar αSyn from damaged neurons may potentiate neuronal…”
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Isolation and characterization of antibody fragment selective for human Alzheimer’s disease brain-derived tau variants by Venkataraman, Lalitha, He, Ping, Schulz, Philip, Sierks, Michael R.

“…Reagents that can selectively recognize specific toxic tau variants associated with onset and progression of Alzheimer’s disease (AD) and other tauopathies can…”
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Monthly Modulations of ENSO Teleconnections: Implications for Potential Predictability in North America by Chapman, William E., Subramanian, Aneesh C., Xie, Shang-Ping, Sierks, Michael D., Ralph, F. Martin, Kamae, Youichi

“…Using a high-resolution atmospheric general circulation model simulation of unprecedented ensemble size, we examine potential predictability of monthly…”
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Characteristics, Origins, and Impacts of Summertime Extreme Precipitation in the Lake Mead Watershed by Sierks, Michael D., Kalansky, Julie, Cannon, Forest, Ralph, F. M.

“…The North American monsoon (NAM) is the main driver of summertime climate variability in the U.S. Southwest. Previous studies of the NAM have primarily focused…”
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Traumatic Brain Injury in Mice Generates Early-Stage Alzheimer’s Disease Related Protein Pathology that Correlates with Neurobehavioral Deficits by Panayi, Nicholas, Schulz, Philip, He, Ping, Hanna, Brandon, Lifshitz, Jonathan, Rowe, Rachel K., Sierks, Michael R.

“…Traumatic brain injury (TBI) increases the long-term risk of neurodegenerative diseases, including Alzheimer’s disease (AD). Here, we demonstrate that protein…”
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A novel nicotinic mechanism underlies β-amyloid-induced neurotoxicity by Liu, Qiang, Xie, Xitao, Emadi, Sharareh, Sierks, Michael R., Wu, Jie

“…Loss of basal forebrain cholinergic neurons (BFCN) correlates with cognitive deficits in Alzheimer disease (AD). Our recent evidence suggests that chronic…”
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Bispecific Antibody Fragment Targeting APP and Inducing α-Site Cleavage Restores Neuronal Health in an Alzheimer’s Mouse Model by He, Ping, Xin, Wei, Schulz, Philip, Sierks, Michael R.

“…The amyloid β (Aβ) peptide, correlated with development of Alzheimer’s disease (AD), is produced by sequential proteolytic cleavage of the amyloid precursor…”
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APP/Aβ structural diversity and Alzheimer's disease pathogenesis by Roher, Alex E., Kokjohn, Tyler A., Clarke, Steven G., Sierks, Michael R., Maarouf, Chera L., Serrano, Geidy E., Sabbagh, Marwan S., Beach, Thomas G.

“…The amyloid cascade hypothesis of Alzheimer's disease (AD) proposes amyloid- β (Aβ) is a chief pathological element of dementia. AD therapies have targeted…”
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CNS disease-related protein variants as blood-based biomarkers in traumatic brain injury by Williams, Stephanie M, Peltz, Carrie, Yaffe, Kristine, Schulz, Philip, Sierks, Michael R

“…To utilize a panel of 11 single chain variable fragments (scFvs) that selectively bind disease-related variants of TAR DNA-binding protein (TDP)-43, β-amyloid,…”
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Inhibiting β-Secretase Activity in Alzheimer's Disease Cell Models with Single-Chain Antibodies Specifically Targeting APP by Boddapati, Shanta, Levites, Yona, Sierks, Michael R.

“…The Amyloid-β (Aβ) peptide is produced from the amyloid precursor protein (APP) by sequential proteolytic cleavage of APP first by β-secretase and then by…”
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Acute sleep deprivation in mice generates protein pathology consistent with neurodegenerative diseases by Rowe, Rachel K, Schulz, Philip, He, Ping, Mannino, Grant S, Opp, Mark R, Sierks, Michael R

“…Insufficient or disturbed sleep is strongly associated with adverse health conditions, including various neurodegenerative disorders. While the relationship…”
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A Sensitive phage-based capture ELISA for sub-femtomolar detection of protein variants directly from biological samples by Williams, Stephanie, Schulz, Philip, Sierks, Michael R.

“…To determine the role of proteins, and in particular protein variants, in human health, it may often be necessary to quantitatively determine the concentration…”
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Isolation and characterization of antibody fragments selective for human FTD brain derived TDP-43 variants by Venkataraman, Lalitha, He, Ping, Khan, Galam, Harris, Brent T, Sierks, Michael R

“…Frontotemporal dementia (FTD) is the second leading cause of early onset dementia following Alzheimer's disease. It involves atrophy of the frontal and…”
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Detecting Morphologically Distinct Oligomeric Forms of α-Synuclein by Emadi, Sharareh, Kasturirangan, Srinath, Wang, Min S., Schulz, Philip, Sierks, Michael R.

“…Neuropathologic and genetics studies as well as transgenic animal models have provided strong evidence linking misfolding and aggregation of α-synuclein to the…”
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CSF levels of oligomeric alpha-synuclein and beta-amyloid as biomarkers for neurodegenerative disease by Sierks, Michael R, Chatterjee, Gaurav, McGraw, Claire, Kasturirangan, Srinath, Schulz, Philip, Prasad, Shalini

“…Protein misfolding and aggregation is a critically important feature in many devastating neurodegenerative diseases, therefore characterization of the CSF…”
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Isolation and characterization of antibody fragments selective for toxic oligomeric tau by Tian, Huilai, Davidowitz, Eliot, Lopez, Patricia, He, Ping, Schulz, Philip, Moe, James, Sierks, Michael R

“…Abstract Oligomeric tau species are important in the onset and progression of Alzheimer's disease (AD), as they are neurotoxic and can propagate tau-tangle…”
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