Search Results - "Sierks, M."

Extracellular Tau Oligomers Produce An Immediate Impairment of LTP and Memory by Fá, M., Puzzo, D., Piacentini, R., Staniszewski, A., Zhang, H., Baltrons, M. A., Li Puma, D. D., Chatterjee, I., Li, J., Saeed, F., Berman, H. L., Ripoli, C., Gulisano, W., Gonzalez, J., Tian, H., Costa, J. A., Lopez, P., Davidowitz, E., Yu, W. H., Haroutunian, V., Brown, L. M., Palmeri, A., Sigurdsson, E. M., Duff, K. E., Teich, A. F., Honig, L. S., Sierks, M., Moe, J. G., D’Adamio, L., Grassi, C., Kanaan, N. M., Fraser, P. E., Arancio, O.

“…Non-fibrillar soluble oligomeric forms of amyloid-β peptide (oAβ) and tau proteins are likely to play a major role in Alzheimer’s disease (AD). The prevailing…”
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Trehalose differentially inhibits aggregation and neurotoxicity of beta-amyloid 40 and 42 by Liu, Ruitian, Barkhordarian, Hedieh, Emadi, Sharareh, Park, Chan Beum, Sierks, Michael R.

“…A key event in Alzheimer's disease (AD) pathogenesis is the conversion of the peptide beta-amyloid (Aβ) from its soluble monomeric form into various aggregated…”
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Observations of an Extreme Atmospheric River Storm With a Diverse Sensor Network by Hatchett, B. J., Cao, Q., Dawson, P. B., Ellis, C. J., Hecht, C. W., Kawzenuk, B., Lancaster, J. T., Osborne, T. C., Wilson, A. M., Anderson, M. L., Dettinger, M. D., Kalansky, J. F., Kaplan, M. L., Lettenmaier, D. P., Oakley, N. S., Ralph, F. M., Reynolds, D. W., White, A. B., Sierks, M., Sumargo, E.

“…Observational networks enhance real‐time situational awareness for emergency and water resource management during extreme weather events. We present examples…”
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Residues 17-20 and 30-35 of beta-amyloid play critical roles in aggregation by Liu, Ruitian, McAllister, Chad, Lyubchenko, Yuri, Sierks, Michael R.

“…We examined the effects of co‐incubating nine different Aβ peptide fragments with full‐length Aβ1–40 (Aβ40) on protein aggregation. Six fragments enhanced…”
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Isolation of an scFv targeting BRG1 using phage display with characterization by AFM by Marcus, W.D., Wang, H., Lohr, D., Sierks, M.R., Lindsay, S.M.

“…Remodeling of chromatin is a vitally important event in processes such as transcription and replication. Brahma-related gene 1 (BRG1) protein is the major…”
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P3.085 Novel bio-panning technique to isolate scFv against low concentrations of toxic natural brain derived Abeta oligomers by Kasturirangan, S, Shankar, G, Selkoe, D, Sierks, M

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Comparison of the domain-level organization of starch hydrolases and related enzymes by JESPERSEN, H. M, MACGREGOR, E. A, SIERKS, M. R, SVENSSON, B

“…Structure-prediction and hydrophobic-cluster analysis of several starch hydrolases and related enzymes indicated the organization of eleven domain types. Most…”
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Quantification of Cytokines Involved in Wound Healing Using Surface Plasmon Resonance by Battaglia, Tina M, Masson, Jean-Francois, Sierks, Michael R, Beaudoin, Stephen P, Rogers, Joseph, Foster, Kevin N, Holloway, G. Allen, Booksh, Karl S

“…Sensing of three cytokines related to chronic wound healing, interleukin-1 (IL-1), interleukin-6 (IL-6), and tumor necrosis factor-α (TNF-α), with detection…”
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Sequence homology between putative raw-starch binding domains from different starch-degrading enzymes by Svensson, B, Jespersen, H, Sierks, M R, MacGregor, E A

“…Primary structures of a wide variety of starch-degrading enzymes have been reported over the past few years. In general, they exhibit little or no homology but…”
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Reaction mechanisms of Trp120→Phe and wild-type glucoamylases from Aspergillus niger. Interactions with maltooligodextrins and acarbose by OLSEN, K, CHRISTENSEN, U, SIERKS, M. R, SVENSSON, B

“…Interactions of wild-type and Trp120-->Phe glucoamylase with maltooligodextrin (Gx) substrates and the tight-binding inhibitor acarbose (A) were investigated…”
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Solvent and viscosity effects on the rate-limiting product release step of glucoamylase during maltose hydrolysis by Sierks, M.R. (University of Maryland Baltimore County, MD.), Sico, C, Zaw, M

“…Release of product from the active site is the rate‐limiting step in a number of enzymatic reactions, including maltose hydrolysis by glucoamylase (GA) . With…”
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Pleomorphism of the marine bacterium Teredinobacter turnirae by Ferreira, G.M., Ahuja, S.K., Sierks, M.R., Moreira, A.R.

“…Aims: A morphology transition for the marine bacterium, Teredinobacter turnirae is reported. Methods and Results: When grown in the rod‐shaped morphology, the…”
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Catalytic Mechanism of Glucoamylase Probed by Mutagenesis in Conjunction with Hydrolysis of α-d-Glucopyranosyl Fluoride and Maltooligosaccharides by Sierks, Michael R, Svensson, Birte

“…The catalytic mechanism of glucoamylase (GA) is investigated by comparing kinetic results obtained using α-d-glucosyl fluoride (GF) and maltooligosaccharides…”
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Roles of the aromatic side chains in the binding of substrates, inhibitors, and cyclomalto-oligosaccharides to the glucoamylase from Aspergillus niger probed by perturbation difference spectroscopy, chemical modification, and mutagenesis by Svensson, B, Sierks, M R

“…The roles of the aromatic side chains of the glucoamylase from Aspergillus niger in the binding of ligands, as determined by difference spectroscopy using four…”
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Identification and Repair of Positive Binding Antibodies Containing Randomly Generated Amber Codons from Synthetic Phage Display Libraries by Marcus, Warren D., Lindsay, Stuart M., Sierks, Michael R.

“…Phage display technology allows for the rapid isolation and characterization of monoclonal antibodies that have vast potential for therapeutic and diagnostic…”
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Evaluation of Isofagomine and Its Derivatives As Potent Glycosidase Inhibitors by Dong, Wenling, Jespersen, Tina, Bols, Mikael, Skrydstrup, Troels, Sierks, Michael R

“…A pseudo-aza-monosaccharide and several pseudo-aza-disaccharide compounds were constructed based on replacement of the anomeric carbon with a nitrogen and the…”
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Catalytic mechanism of fungal glucoamylase as defined by mutagenesis of Asp176, Glu179 and Glu180 in the enzyme from Aspergillus awamori by Sierks, M R, Ford, C, Reilly, P J, Svensson, B

“…Asp176, Glu179 and Glu180 of Aspergillus awamori glucoamylase appeared by differential labeling to be in the active site. To test their functions, they were…”
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Functional roles of the invariant aspartic acid 55, tyrosine 306, and aspartic acid 309 in glucoamylase from Aspergillus awamori studied by mutagenesis by Sierks, Michael R, Svensson, Birte

“…Three mutants, Asp55-Gly, Tyr306 replaced by Phe, and Asp309 replaced by Asn, of Aspergillus awamori glucoamylase (identical to Aspergillus niger glucoamylase)…”
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Kinetic identification of a hydrogen bonding pair in the glucoamylase-maltose transition state complex by Sierks, M R, Svensson, B

“…Molecular recognition and site-directed mutagenesis are used in combination to identify kinetically, transition state interactions between glucoamylase (GA)…”
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Specific Glycosidase Activity Isolated from a Random Phage Display Antibody Library by Goud, Gaddam Narsa, Artsaenko, Olga, Bols, Mikael, Sierks, Michael

“…Carbohydrates serve as key receptor sites in various cellular events such as viral attachment, tumor formation, and tissue inflammation. A potential route to…”
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