Search Results - "Sienaert, Ilse"

Localization and function of a calmodulin-apocalmodulin-binding domain in the N-terminal part of the type 1 inositol 1,4,5-trisphosphate receptor by Sienaert, Ilse, Nadif Kasri, Nael, Vanlingen, Sara, Parys, Jan B, Callewaert, Geert, Missiaen, Ludwig, de Smedt, Humbert

“…Calmodulin (CaM) is a ubiquitous protein that plays a critical role in regulating cellular functions by altering the activity of a large number of proteins,…”
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Molecular and Functional Evidence for Multiple Ca2+-binding Domains in the Type 1 Inositol 1,4,5-Trisphosphate Receptor by Sienaert, Ilse, Missiaen, Ludwig, De Smedt, Humbert, Parys, Jan B., Sipma, Henk, Casteels, Rik

“…Structural and functional analyses were used to investigate the regulation of the inositol 1,4,5-trisphosphate (InsP3) receptor (InsP3R) by Ca2+. To define the…”
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Ca2+-calmodulin inhibits Ca2+ release mediated by type-1, -2 and -3 inositol trisphosphate receptors by Adkins, C E, Morris, S A, De Smedt, H, Sienaert, I, Török, K, Taylor, C W

“…InsP(3) binding to type-1, but not type-3, InsP(3) receptors is inhibited by calmodulin in a Ca(2+)-independent fashion [Cardy and Taylor (1998) Biochem. J…”
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Characterization of a Cytosolic and a Luminal Ca2+ Binding Site in the Type I Inositol 1,4,5-Trisphosphate Receptor by Sienaert, I, De Smedt, H, Parys, J B, Missiaen, L, Vanlingen, S, Sipma, H, Casteels, R

“…To study the Ca 2+ regulation of the inositol 1,4,5-trisphosphate receptor (InsP 3 R) at the molecular level, we expressed various cytosolic and luminal…”
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Mapping of the ATP-binding Sites on Inositol 1,4,5-Trisphosphate Receptor Type 1 and Type 3 Homotetramers by Controlled Proteolysis and Photoaffinity Labeling by Maes, Karlien, Missiaen, Ludwig, Parys, Jan B., De Smet, Patrick, Sienaert, Ilse, Waelkens, Etienne, Callewaert, Geert, De Smedt, Humbert

“…Submillimolar ATP concentrations strongly enhance the inositol 1,4,5-trisphosphate (IP3)-induced Ca2+ release, by binding specifically to ATP-binding sites on…”
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Modulation of Inositol 1,4,5-Trisphosphate Binding to the Recombinant Ligand-binding Site of the Type-1 Inositol 1,4,5-Trisphosphate Receptor by Ca2+ and Calmodulin by Sipma, H, De Smet, P, Sienaert, I, Vanlingen, S, Missiaen, L, Parys, J B, De Smedt, H

“…A recombinant protein (Lbs-1) containing the N-terminal 581 amino acids of the mouse type 1 inositol 1,4,5-trisphosphate receptor (IP 3 R-1), including the…”
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A Novel Ca2+-induced Ca2+ Release Mechanism in A7r5 Cells Regulated by Calmodulin-like Proteins by Kasri, Nael Nadif, Sienaert, Ilse, Parys, Jan B., Callewaert, Geert, Missiaen, Ludwig, Jeromin, Andreas, De Smedt, Humbert

“…Intracellular Ca2+ release is involved in setting up Ca2+ signals in all eukaryotic cells. Here we report that an increase in free Ca2+ concentration triggered…”
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Inhibition of the Inositol Trisphosphate Receptor of Mouse Eggs and A7r5 Cells by KN-93 via a Mechanism Unrelated to Ca2+/Calmodulin-dependent Protein Kinase II Antagonism by Smyth, Jeremy T, Abbott, Allison L, Lee, Bora, Sienaert, Ilse, Kasri, Nael Nadif, De Smedt, Humbert, Ducibella, Tom, Missiaen, Ludwig, Parys, Jan B, Fissore, Rafael A

“…KN-93, a Ca 2+ /calmodulin-dependent protein kinase II (CaMKII) inhibitor, concentration-dependently and reversibly inhibited inositol 1,4,5-trisphosphate…”
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Effect of adenine nucleotides on myo-inositol-1,4,5-trisphosphate-induced calcium release by Missiaen, L, Parys, J B, Smedt, H D, Sienaert, I, Sipma, H, Vanlingen, S, Maes, K, Casteels, R

“…The effects of a whole series of adenine nucleotides on Ins(1,4,5)P3-induced Ca2+ release were characterized in permeabilized A7r5 smooth-muscle cells. Several…”
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Threshold for Inositol 1,4,5-Trisphosphate Action (∗) by Missiaen, Ludwig, De Smedt, Humbert, Parys, Jan B., Sienaert, Ilse, Vanlingen, Sara, Casteels, Rik

“…We developed a unidirectional 45Ca2+ efflux technique in which 60 cumulative doses of inositol 1,4,5-trisphosphate (InsP3), each lasting 6 s, were subsequently…”
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Hypotonically Induced Calcium Release from Intracellular Calcium Stores by Missiaen, L, De Smedt, H, Parys, J B, Sienaert, I, Vanlingen, S, Droogmans, G, Nilius, B, Casteels, R

“…Osmotic cell swelling induced by hypotonic stress is associated with a rise in intracellular Ca concentration, which is at least partly due to a release of Ca…”
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Ca2+-calmodulin inhibits Ca2+ release mediated by type-1, -2 and -3 inositol trisphosphate receptors by ADKINS, Charles E., MORRIS, Stephen A., DE SMEDT, Humbert, SIENAERT, Ilse, TÖRÖK, Katalin, TAYLOR, Colin W.

“…InsP3 binding to type-1, but not type-3, InsP3 receptors is inhibited by calmodulin in a Ca2+-independent fashion [Cardy and Taylor (1998) Biochem. J. 334,…”
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Synthesis and in vitro evaluation of 2-amino-4-N-piperazinyl-6-(3,4-dimethoxyphenyl)-pteridines as dual immunosuppressive and anti-inflammatory agents by De Jonghe, Steven, Marchand, Arnaud, Gao, Ling-Jie, Calleja, Agnes, Cuveliers, Eva, Sienaert, Ilse, Herman, Jean, Clydesdale, Gavin, Sefrioui, Hassane, Lin, Yuan, Pfleiderer, Wolfgang, Waer, Mark, Herdewijn, Piet

“…Screening of a pteridine-based compound library led to the identification of compounds exhibiting immunosuppressive as well as anti-inflammatory activity…”
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The role of calmodulin for inositol 1,4,5-trisphosphate receptor function by Nadif Kasri, Nael, Bultynck, Geert, Sienaert, Ilse, Callewaert, Geert, Erneux, Christophe, Missiaen, Ludwig, Parys, Jan B, De Smedt, Humbert

“…Intracellular calcium release is a fundamental signaling mechanism in all eukaryotic cells. The ryanodine receptor (RyR) and inositol 1,4,5-trisphosphate…”
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Immunosuppressive activity of a new pteridine derivative (4AZA1378) alleviates severity of TNBS-induced colitis in mice by Shen, Chong, Dillissen, Ellen, Kasran, Ahmad, Lin, Yuan, Herman, Jean, Sienaert, Ilse, De Jonghe, Steven, Kerremans, Luk, Geboes, Karel, Boon, Louis, Rutgeerts, Paul, Ceuppens, Jan L

“…Abstract Besides TNF, activated T cells play a central role in the pathogenesis of inflammatory bowel diseases such as Crohn's disease. New therapies are still…”
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Functional Properties of the Type-3 InsP3 Receptor in 16HBE14o− Bronchial Mucosal Cells by Missiaen, Ludwig, Parys, Jan B., Sienaert, Ilse, Maes, Karlien, Kunzelmann, Karl, Takahashi, Masaaki, Tanzawa, Kazuhiko, De Smedt, Humbert

“…The type-3 inositol 1,4,5-trisphosphate (InsP3) receptor is the major isoform expressed in 16HBE14o− cells from bronchial mucosa, representing 93% at the mRNA…”
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Isoform diversity of the inositol trisphosphate receptor in cell types of mouse origin by De Smedt, H, Missiaen, L, Parys, J B, Henning, R H, Sienaert, I, Vanlingen, S, Gijsens, A, Himpens, B, Casteels, R

“…Previous reports suggested the expression of four or five different Ins(1,4,5)P3 receptor [Ins(1,4,5)P3R] isoforms in mouse cells [Ross, Danoff, Schell, Snyder…”
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Anti-inflammatory activity of a pteridine derivative (4AZA2096) alleviates TNBS-induced colitis in mice by Shen, Chong, Dillissen, Ellen, Kasran, Ahmad, Lin, Yuan, Clydesdale, Gavin, Sienaert, Ilse, Jonghe, Steven De, Gao, Ling-Jie, Geboes, Karel, Boon, Louis, Rutgeerts, Paul, Ceuppens, Jan L

“…Elevated production of tumor necrosis factor (TNF) plays a central role in the pathogenesis of many inflammatory diseases, such as rheumatoid arthritis and…”
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Basic properties of an inositol 1,4,5-trisphosphate-gated channel in carp olfactory cilia by Cadiou, Hervé, Sienaert, Ilse, Vanlingen, Sara, Parys, Jan B., Molle, Gérard, Duclohier, Hervé

“…In addition to the activation of cAMP‐dependent pathways, odorant binding to its receptor can lead to inositol 1,4,5‐trisphosphate (InsP3) production that may…”
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Mechanisms responsible for quantal Ca2+ release from inositol trisphosphate-sensitive calcium stores by Parys, J B, Missiaen, L, Smedt, H D, Sienaert, I, Casteels, R

“…Activation of cells by hormones, growth factors or neurotransmitters leads to an increased production of inositol trisphosphate (InsP3) and, after activation…”
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