Search Results - "Siemasko, Karyn"

NK cells promote Th-17 mediated corneal barrier disruption in dry eye by Zhang, Xiaobo, Volpe, Eugene A, Gandhi, Niral B, Schaumburg, Chris S, Siemasko, Karyn F, Pangelinan, Solherny B, Kelly, Scott D, Hayday, Adrian C, Li, De-Quan, Stern, Michael E, Niederkorn, Jerry Y, Pflugfelder, Stephen C, De Paiva, Cintia S

“…The conjunctiva contains a specialized population of lymphocytes that reside in the epithelium, named intraepithelial lymphocytes (IEL). Here we characterized…”
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Ocular surface APCs are necessary for autoreactive T cell-mediated experimental autoimmune lacrimal keratoconjunctivitis by Schaumburg, Chris S, Siemasko, Karyn F, De Paiva, Cintia S, Wheeler, Larry A, Niederkorn, Jerry Y, Pflugfelder, Stephen C, Stern, Michael E

“…As specialized sentinels between the innate and adaptive immune response, APCs are essential for activation of Ag-specific lymphocytes, pathogen clearance, and…”
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The role of the lacrimal functional unit in the pathophysiology of dry eye by Stern, Michael E, Gao, Jianping, Siemasko, Karyn F, Beuerman, Roger W, Pflugfelder, Stephen C

“…The majority of dry eye symptoms are due to a chronic inflammation of the lacrimal functional unit resulting in a loss of tear film integrity and normal…”
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Autoantibodies contribute to the immunopathogenesis of experimental dry eye disease by Stern, Michael E, Schaumburg, Chris S, Siemasko, Karyn F, Gao, Jianping, Wheeler, Larry A, Grupe, Devin A, De Paiva, Cintia S, Calder, Virginia L, Calonge, Margarita, Niederkorn, Jerry Y, Pflugfelder, Stephen C

“…The purpose of this study was to determine if autoantibodies play a role in the immunopathogenesis of experimental dry eye disease. Dry eye was induced by…”
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In Vitro Expanded CD4+CD25+Foxp3+ Regulatory T Cells Maintain a Normal Phenotype and Suppress Immune-Mediated Ocular Surface Inflammation by Siemasko, Karyn F, Gao, Jianping, Calder, Virginia L, Hanna, Rebecca, Calonge, Margarita, Pflugfelder, Stephen C, Niederkorn, Jerry Y, Stern, Michael E

“…To determine whether in vitro expanded CD4(+)CD25(+)Foxp3(+) regulatory T cells can suppress immune-mediated ocular surface inflammation in a mouse model of…”
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Characterization of a Spontaneously Immortalized Cell Line (IOBA-NHC) from Normal Human Conjunctiva by Diebold, Yolanda, Calonge, Margarita, de Salamanca, Amalia Enriquez, Callejo, Sagrario, Corrales, Rosa M, Saez, Victoria, Siemasko, Karyn F, Stern, Michael E

“…To characterize a new nontransfected, spontaneously immortalized epithelial cell line from normal human conjunctiva (IOBA-NHC), both morphologically and…”
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The Direct Recruitment of BLNK to Immunoglobulin α Couples the B-Cell Antigen Receptor to Distal Signaling Pathways by Kabak, Shara, Skaggs, Brian J., Gold, Michael R., Affolter, Michael, West, Kelly L., Foster, Mark S., Siemasko, Karyn, Chan, Andrew C., Aebersold, Ruedi, Clark, Marcus R.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Expression of Muscarinic and Adrenergic Receptors in Normal Human Conjunctival Epithelium by de Salamanca, Amalia Enriquez, Siemasko, Karyn F, Diebold, Yolanda, Calonge, Margarita, Gao, Jianping, Juarez-Campo, Monica, Stern, Michael E

“…To study the presence of muscarinic and alpha- and beta-adrenergic receptors in a normal human conjunctival epithelial (IOBA-NHC) cell line. Neurotransmitter…”
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The Th1/Th2 paradigm in ocular allergy by Stern, Michael E, Siemasko, Karyn F, Niederkorn, Jerry Y

“…PURPOSE OF REVIEWThe paradigm that diseases are either Th1 mediated or Th2 mediated has recently been challenged in a number of classical ocular diseases. The…”
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Inhibition of JAK3 and STAT6 Tyrosine Phosphorylation by the Immunosuppressive Drug Leflunomide Leads to a Block in IgG1 Production by Siemasko, Karyn, Chong, Anita S-F, Jack, Hans-Martin, Gong, Haihua, Williams, James W, Finnegan, Alison

“…Leflunomide is an immunosuppressive drug capable of inhibiting T and B cell responses in vivo. A number of studies demonstrate that leflunomide functions both…”
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Study Design of LONG RUN: A LONGitudinal Evaluation and Real-World Evidence of Uniquely Purified IncobotulinumtoxinA in Treatment-Naïve Participants by Curry, Andy, Keaney, Terrence, Siemasko, Karyn

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Molecular Mechanisms of B Cell Antigen Receptor Trafficking by CLARK, MARCUS R., MASSENBURG, DON, ZHANG, MIAO, SIEMASKO, KARYN

“…: B lymphocytes are among the most efficient cells of the immune system in capturing, processing, and presenting MHC class II restricted peptides to T cells…”
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Cutting Edge: Signals from the B Lymphocyte Antigen Receptor Regulate MHC Class II Containing Late Endosomes by Siemasko, Karyn, Eisfelder, Bartholomew J, Williamson, Edward, Kabak, Shara, Clark, Marcus R

“…The B lymphocyte response to protein Ag is dependent upon the successful presentation to T cells of Ag-derived, MHC class II-restricted peptides. The B cell Ag…”
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Evaluation of Ocular Surface Inflammation in the Presence of Dry Eye and Allergic Conjunctival Disease by Stern, Michael E., Siemasko, Karyn F., Gao, Jianping, Calonge, Margarita, Niederkorn, Jerry Y., Pflugfelder, Stephen C.

“…The ocular inflammatory diseases dry eye and allergic conjunctivitis are mediated by CD4+ T cells. Th1 cells secrete interferon (IFN)-γ and are implicated in…”
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Cooperative interaction of Igα and Igβ of the BCR regulates the kinetics and specificity of antigen targeting by Li, Chang, Siemasko, Karyn, Clark, Marcus R., Song, Wenxia

“…Following the binding of antigens, the BCR transduces signals and internalizes antigens for processing and presentation, both of which are required for…”
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Animal models of ocular allergy and their clinical correlations by Calonge, Margarita, Siemasko, Karyn F, Stern, Michael E

“…Ocular allergic diseases represent a wide spectrum of disorders, from the acute self-limited, mild form of seasonal allergic conjunctivitis to the chronic,…”
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Variation in the Expression of Inflammatory Markers and Neuroreceptors in Human Conjunctival Epithelial Cells by Calonge, Margarita, de Salamanca, Amalia Enríquez, Siemasko, Karyn F., Diebold, Yolanda, Gao, Jianping, Juárez-Campo, Mónica, Stern, Michael E.

“…The purpose of this research was to investigate the role of neurogenic involvement in the etiopathogenesis of ocular surface inflammation, with the final goal…”
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Desiccating Stress Induces T Cell-Mediated Sjogren's Syndrome-Like Lacrimal Keratoconjunctivitis by Niederkorn, Jerry Y, Stern, Michael E, Pflugfelder, Stephen C, De Paiva, Cintia S, Corrales, Rosa M, Gao, Jianping, Siemasko, Karyn

“…Chronic dry eye syndrome affects over 10 million people in the United States; it is associated with inflammation of the lacrimal gland (LG) and in some cases…”
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Involvement of LFA-1 and ICAM-1 in the herpetic disease resulting from HSV-1 corneal infection by Dennis, R F, Siemasko, K F, Tang, Q, Hendricks, R L, Finnegan, A

“…Herpes simplex virus type 1 (HSV-1) corneal infection in immunologically normal mice results in a transient epithelial lesion followed in about 2 weeks by a…”
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Role of interferon-γ in a mouse model of allergic conjunctivitis by STERN, Michael E, SIEMASKO, Karyn, JIANPING GAO, DUONG, Anh, BEAUREGARD, Clay, COLDER, Virginia, NIEDERKORN, Jerry Y

“…To characterize the effect of repeated topical exposure to allergen in a mouse model of allergic conjunctivitis and to determine the role of interferon-gamma…”
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