Search Results - "Siemann, Dietmar"

The unique characteristics of tumor vasculature and preclinical evidence for its selective disruption by Tumor-Vascular Disrupting Agents by Siemann, Dietmar W

“…Abstract The vasculature of solid tumors is fundamentally different from that of normal vasculature and offers a unique target for anti-cancer therapy. Direct…”
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Gas6/Axl Signaling Pathway in the Tumor Immune Microenvironment by Tanaka, Mai, Siemann, Dietmar W.

“…Receptor tyrosine kinases have been shown to dysregulate a number of pathways associated with tumor development, progression, and metastasis. Axl is a receptor…”
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Therapeutic Targeting of the Gas6/Axl Signaling Pathway in Cancer by Tanaka, Mai, Siemann, Dietmar W

“…Many signaling pathways are dysregulated in cancer cells and the host tumor microenvironment. Aberrant receptor tyrosine kinase (RTK) pathways promote cancer…”
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Cathepsin L targeting in cancer treatment by Sudhan, Dhivya R, Siemann, Dietmar W

“…Proteolytic enzymes may serve as promising targets for novel therapeutic treatment strategies seeking to impede cancer progression and metastasis. One such…”
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Modulation of the tumor vasculature and oxygenation to improve therapy by Siemann, Dietmar W, Horsman, Michael R

“…The tumor microenvironment is increasingly recognized as a major factor influencing the success of therapeutic treatments and has become a key focus for cancer…”
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Axl signaling is an important mediator of tumor angiogenesis by Tanaka, Mai, Siemann, Dietmar W

“…The growth of primary tumors as well as metastatic neoplastic lesions is strongly dependent on the cancer cells' ability to initiate their own vascular…”
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Targeting the Angiopoietin-2/Tie-2 axis in conjunction with VEGF signal interference by Biel, Nikolett M, Siemann, Dietmar W

“…Highlights • Anti-angiogenic therapies such as Ang-2 and VEGF targeted agents have been heavily pursued in oncologic settings. • Angiopoietin/Tie2 system plays…”
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Tumor oxygenation and cancer therapy-then and now by Hughes, Veronica S, Wiggins, Jennifer M, Siemann, Dietmar W

“…In 2012, cancer affected 14.1 million people worldwide and was responsible for 8.2 million deaths. The disease predominantly affects aged populations and is…”
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Inhibition of the Axl pathway impairs breast and prostate cancer metastasis to the bones and bone remodeling by Tanaka, Mai, Dykes, Samantha S., Siemann, Dietmar W.

“…Approximately 90% of cancer-related deaths result from cancer metastasis. In prostate and breast cancers, bone is the most common site of cancer cell…”
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Cathepsin L inactivation leads to multimodal inhibition of prostate cancer cell dissemination in a preclinical bone metastasis model by Sudhan, Dhivya R., Pampo, Christine, Rice, Lori, Siemann, Dietmar W.

“…It is estimated that approximately 90% of patients with advanced prostate cancer develop bone metastases; an occurrence that results in a substantial reduction…”
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Reliability of blood lactate as a measure of exercise intensity in different strains of mice during forced treadmill running by Lønbro, Simon, Wiggins, Jennifer M, Wittenborn, Thomas, Elming, Pernille Byrialsen, Rice, Lori, Pampo, Christine, Lee, Jennifer A, Siemann, Dietmar W, Horsman, Michael R

“…Exercise has long been known to be beneficial to human health. Studies aimed at understanding the effects of exercise specifically focus on predetermined…”
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A review and update of the current status of the vasculature-disabling agent combretastatin-A4 phosphate (CA4P) by Siemann, Dietmar W, Chaplin, David J, Walicke, Patricia A

“…Vascular-disrupting strategies impair a tumor's blood vessel network, which is essential for tumor progression and metastasis. Vascular-disrupting agents…”
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Modulation of Blood Flow, Hypoxia, and Vascular Function in Orthotopic Prostate Tumors During Exercise by MCCULLOUGH, Danielle J, STABLEY, John N, SIEMANN, DietmarW, BEHNKE, Bradley J

“…Previous studies have hypothesized that tumor blood flow may be elevated or reduced during exercise, which could impact the tumor microenvironment. However, to…”
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Pathophysiologic effects of vascular-targeting agents and the implications for combination with conventional therapies by HORSMAN, Michael R, SIEMANN, Dietmar W

“…A functional vascular supply is critical for the continued growth and development of solid tumors. It also plays a major role in metastatic spread of tumor…”
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Cathepsin L inhibition by the small molecule KGP94 suppresses tumor microenvironment enhanced metastasis associated cell functions of prostate and breast cancer cells by Sudhan, Dhivya R., Siemann, Dietmar W.

“…Metastasis remains the major cause of therapeutic failure, poor prognosis and high mortality in breast and prostate cancer patients. Aberrant microenvironments…”
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Impact of Hypoxia on the Metastatic Potential of Human Prostate Cancer Cells by Dai, Yao, Ph.D, Bae, Kyungmi, Ph.D, Siemann, Dietmar W., Ph.D

“…Purpose Intratumoral hypoxia is known to be associated with radioresistance and metastasis. The present study examined the effect of acute and chronic hypoxia…”
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Towards an integrative understanding of cancer mechanobiology: calcium, YAP, and microRNA under biophysical forces by Liang, Chenyu, Huang, Miao, Li, Tianqi, Li, Lu, Sussman, Hayley, Dai, Yao, Siemann, Dietmar W, Xie, Mingyi, Tang, Xin

“…An increasing number of studies have demonstrated the significant roles of the interplay between microenvironmental mechanics in tissues and…”
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BMS-777607, a small-molecule met kinase inhibitor, suppresses hepatocyte growth factor-stimulated prostate cancer metastatic phenotype in vitro by Dai, Yao, Siemann, Dietmar W

“…Most prostate cancer-related deaths are due to advanced disease with patients with metastatic prostate cancer having a 5-year survival rate of only 34%…”
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Epithelial-to-mesenchymal transition confers pericyte properties on cancer cells by Shenoy, Anitha K, Jin, Yue, Luo, Huacheng, Tang, Ming, Pampo, Christine, Shao, Rong, Siemann, Dietmar W, Wu, Lizi, Heldermon, Coy D, Law, Brian K, Chang, Lung-Ji, Lu, Jianrong

“…Carcinoma cells can acquire increased motility and invasiveness through epithelial-to-mesenchymal transition (EMT). However, the significance of EMT in cancer…”
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Constitutively active c-Met kinase in PC-3 cells is autocrine-independent and can be blocked by the Met kinase inhibitor BMS-777607 by Dai, Yao, Siemann, Dietmar W

“…The c-Met receptor tyrosine kinase is aberrantly activated in many solid tumors. In a prior study we showed that prostate cancer PC-3 cells exhibit…”
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