Search Results - "Sieliwonczyk, Ewa"

Improved selection of zebrafish CRISPR editing by early next-generation sequencing based genotyping by Sieliwonczyk, Ewa, Vandendriessche, Bert, Claes, Charlotte, Mayeur, Evy, Alaerts, Maaike, Holmgren, Philip, Canter Cremers, Tycho, Snyders, Dirk, Loeys, Bart, Schepers, Dorien

“…Despite numerous prior attempts to improve knock-in (KI) efficiency, the introduction of precise base pair substitutions by the CRISPR-Cas9 technique in…”
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Clinical and functional characterisation of a recurrent KCNQ1 variant in the Belgian population by Sieliwonczyk, Ewa, Alaerts, Maaike, Simons, Eline, Snyders, Dirk, Nijak, Aleksandra, Vandendriessche, Bert, Schepers, Dorien, Akdeniz, Dogan, Van Craenenbroeck, Emeline, Knaepen, Katleen, Rabaut, Laura, Heidbuchel, Hein, Van Laer, Lut, Saenen, Johan, Labro, Alain J, Loeys, Bart

“…The c.1124_1127delTTCA p.(Ile375Argfs*43) pathogenic variant is the most frequently identified molecular defect in the KCNQ1 gene in the cardiogenetics clinic…”
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Artificial intelligence-enhanced electrocardiography derived body mass index as a predictor of future cardiometabolic disease by Pastika, Libor, Sau, Arunashis, Patlatzoglou, Konstantinos, Sieliwonczyk, Ewa, Ribeiro, Antônio H., McGurk, Kathryn A., Khan, Sadia, Mandic, Danilo, Scott, William R., Ware, James S., Peters, Nicholas S., Ribeiro, Antonio Luiz P., Kramer, Daniel B., Waks, Jonathan W., Ng, Fu Siong

“…The electrocardiogram (ECG) can capture obesity-related cardiac changes. Artificial intelligence-enhanced ECG (AI-ECG) can identify subclinical disease. We…”
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Optical Mapping in hiPSC-CM and Zebrafish to Resolve Cardiac Arrhythmias by Vandendriessche, Bert, Sieliwonczyk, Ewa, Alaerts, Maaike, Loeys, Bart L., Snyders, Dirk, Schepers, Dorien

“…Inherited cardiac arrhythmias contribute substantially to sudden cardiac death in the young. The underlying pathophysiology remains incompletely understood…”
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Compound Heterozygous SCN5A Mutations in Severe Sodium Channelopathy With Brugada Syndrome: A Case Report by Nijak, Aleksandra, Labro, Alain J., De Wilde, Hans, Dewals, Wendy, Peigneur, Steve, Tytgat, Jan, Snyders, Dirk, Sieliwonczyk, Ewa, Simons, Eline, Van Craenenbroeck, Emeline, Schepers, Dorien, Van Laer, Lut, Saenen, Johan, Loeys, Bart, Alaerts, Maaike

“…Aims: Brugada syndrome (BrS) is an inherited cardiac arrhythmia with an increased risk for sudden cardiac death (SCD). About 20% of BrS cases are explained by…”
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Morpho-functional comparison of differentiation protocols to create iPSC-derived cardiomyocytes by Nijak, Aleksandra, Simons, Eline, Vandendriessche, Bert, Van de Sande, Dieter, Fransen, Erik, Sieliwończyk, Ewa, Van Gucht, Ilse, Van Craenenbroeck, Emeline, Saenen, Johan, Heidbuchel, Hein, Ponsaerts, Peter, Labro, Alain J, Snyders, Dirk, De Vos, Winnok, Schepers, Dorien, Alaerts, Maaike, Loeys, Bart L

“…Cardiomyocytes derived from induced pluripotent stem cells (iPSC-CMs) offer an attractive platform for cardiovascular research. Patient-specific iPSC-CMs are…”
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Abstract 4137169: Artificial Intelligence-Enabled Electrocardiography For The Prediction of Future Type 2 Diabetes Mellitus by Pastika, Libor, Patlatzoglou, Konstantinos, Sieliwonczyk, Ewa, Barker, Joseph, Zeidaabadi, Boroumand, McGurk, Kathryn, Khan, Sadia, Mandic, Danilo, Ware, James, Peters, Nicholas, Kramer, Daniel, Waks, Jonathan, Sau, Arunashis, Ng, Fu Siong

“…Abstract only Background: Undiagnosed diabetes and prediabetes present a significant global health challenge. Artificial Intelligence-enabled…”
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Sex-specific Genetic Determinants of Right Ventricular Structure and Function by Harbaum, Lars, Hennigs, Jan K, Pott, Julian, Ostermann, Jonna, Sinning, Christoph R, Sau, Arunashis, Sieliwonczyk, Ewa, Ng, Fu Siong, Rhodes, Christopher J, Tello, Khodr, Klose, Hans, Gräf, Stefan, Wilkins, Martin R

“…While sex differences in right heart phenotypes have been observed, the molecular drivers remain unknown. To provide biological insights into sex differences…”
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PO-03-008 ARTIFICIAL INTELLIGENCE-ENHANCED ELECTROCARDIOGRAPHY IDENTIFIES FEMALE-SPECIFIC ELEVATED CARDIOVASCULAR RISK PROFILE by Sau, Arunashis, Sieliwonczyk, Ewa, Patlatzoglou, Konstantinos, Pastika, Libor, McGurk, Kathryn, Ribeiro, Antônio, Ribeiro, Antonio L., Peters, Nicholas S., Ware, James S., Tayal, Upasana, Kramer, Daniel B., Waks, Jonathan, Ng, Fu Siong

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CE-469620-001 AN ARTIFICIAL INTELLIGENCE–ENABLED ELECTROCARDIOGRAPHY PLATFORM FOR MORTALITY, ATHEROSCLEROTIC CARDIOVASCULAR DISEASE, HEART FAILURE AND VENTRICULAR ARRHYTHMIA PREDICTION by Sau, Arunashis, Pastika, Libor, Sieliwonczyk, Ewa, Patlatzoglou, Konstantinos, Ribeiro, Antonio, McGurk, Kathryn, Zeidaabadi, Boroumand, Zhang, Henry, Macierzanka, Krzysztof, Mandic, Danilo, Sabino, Ester, Giatti, Luana, Barreto, Sandhi, Camelo, Lidyane d., Tzoulaki, Ioanna, O'Regan, Declan P., Peters, Nicholas S., Ware, James S., Ribeiro, Antonio L., Kramer, Daniel B., Waks, Jonathan, Ng, Fu Siong

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Prognostic Significance and Associations of Neural Network–Derived Electrocardiographic Features by Sau, Arunashis, Ribeiro, Antônio H., McGurk, Kathryn A., Pastika, Libor, Bajaj, Nikesh, Gurnani, Mehak, Sieliwonczyk, Ewa, Patlatzoglou, Konstantinos, Ardissino, Maddalena, Chen, Jun Yu, Wu, Huiyi, Shi, Xili, Hnatkova, Katerina, Zheng, Sean L., Britton, Annie, Shipley, Martin, Andršová, Irena, Novotný, Tomáš, Sabino, Ester C., Giatti, Luana, Barreto, Sandhi M., Waks, Jonathan W., Kramer, Daniel B., Mandic, Danilo, Peters, Nicholas S., O’Regan, Declan P., Malik, Marek, Ware, James S., Ribeiro, Antonio Luiz P., Ng, Fu Siong

“…BACKGROUND: Subtle, prognostically important ECG features may not be apparent to physicians. In the course of supervised machine learning, thousands of ECG…”
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Headache in a patient with polycythemia by Sieliwonczyk, Ewa, Vlieghe, Erika, Van Dijck, Christophe

“…Myeloprolipherative neoplasms (MPN) are rare conditions with an annual incidence of approximately 5.4/100 000. The main classic MPN are polycythemia vera (PV),…”
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Clinical characterization of the first Belgian SCN5A founder mutation cohort by Sieliwonczyk, Ewa, Alaerts, Maaike, Robyns, Tomas, Schepers, Dorien, Claes, Charlotte, Corveleyn, Anniek, Willems, Rik, Van Craenenbroeck, Emeline M, Simons, Eline, Nijak, Aleksandra, Vandendriessche, Bert, Mortier, Geert, Vrints, Christiaan, Koopman, Pieter, Heidbuchel, Hein, Van Laer, Lut, Saenen, Johan, Loeys, Bart

“…Abstract Aims We identified the first Belgian SCN5A founder mutation, c.4813 + 3_4813 + 6dupGGGT. To describe the clinical spectrum and disease severity…”
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Inherited Ventricular Arrhythmia in Zebrafish: Genetic Models and Phenotyping Tools by Sieliwonczyk, Ewa, Matchkov, Vladimir V, Vandendriessche, Bert, Alaerts, Maaike, Bakkers, Jeroen, Loeys, Bart, Schepers, Dorien

“…In the last years, the field of inheritable ventricular arrhythmia disease modelling has changed significantly with a push towards the use of novel cellular…”
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Molecular autopsy and subsequent functional analysis reveal de novo DSG2 mutation as cause of sudden death by Simons, Eline, Labro, Alain, Saenen, Johan, Nijak, Aleksandra, Sieliwonczyk, Ewa, Vandendriessche, Bert, Dąbrowska, Małgorzata, Van Craenenbroeck, Emeline M., Schepers, Dorien, Van Laer, Lut, Loeys, Bart L., Alaerts, Maaike

“…Sudden cardiac death (SCD) is a common cause of death in young adults. In up to 80% of cases a genetic cause is suspected. Next-generation sequencing of…”
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MP-470543-005 UNSUPERVISED ECG FEATURE EXTRACTION USING DEEP LEARNING EMPOWERS DISCOVERY OF GENETIC DETERMINANTS OF CARDIAC ELECTROPHYSIOLOGY by Sieliwonczyk, Ewa, Sau, Arunashis, Patlatzoglou, Konstantinos, McGurk, Kathryn, Pastika, Libor, Thami, Prisca, Mangino, Massimo, Zheng, Sean, Powell, George, Curran, Lara, Buchan, Rachel, Theotokis, Pantazis, Peters, Nicholas S., Loeys, Bart, Kramer, Daniel B., Waks, Jonathan, Ng, Fu Siong, Ware, James S.

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Artificial intelligence-enabled electrocardiogram for mortality and cardiovascular risk estimation: a model development and validation study by Sau, Arunashis, Pastika, Libor, Sieliwonczyk, Ewa, Patlatzoglou, Konstantinos, Ribeiro, Antônio H, McGurk, Kathryn A, Zeidaabadi, Boroumand, Zhang, Henry, Macierzanka, Krzysztof, Mandic, Danilo, Sabino, Ester, Giatti, Luana, Barreto, Sandhi M, Camelo, Lidyane do Valle, Tzoulaki, Ioanna, O'Regan, Declan P, Peters, Nicholas S, Ware, James S, Ribeiro, Antonio Luiz P, Kramer, Daniel B, Waks, Jonathan W, Ng, Fu Siong

“…Artificial intelligence (AI)-enabled electrocardiography (ECG) can be used to predict risk of future disease and mortality but has not yet been adopted into…”
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Decline in kidney function in a patient with elevated auto-antibody titres and a rare haematological disorder by Sieliwonczyk, Ewa, Bosmans, Jean-Louis, Van den Driessche, Annelies, Georgieva, Lyuba

“…T-cell leukemia with large granular lymphocytes (T-LGL) is a chronic lymphoproliferative disorder with a good prognosis. It is caused by an accumulation of…”
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26 - Mapping of Cardiac Action Potentials in Zebrafish to Assess Genetic Variants by Schepers, Dorien, Sieliwonczyk, Ewa, Loeys, Bart

“…Next-generation sequencing technologies have accelerated molecular diagnosis for inherited cardiac arrhythmias. However, we are confronted with the sobering…”
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Mapping of Cardiac Action Potentials in Zebrafish to Assess Genetic Variants by Schepers, Dorien, Sieliwonczyk, Ewa, Loeys, Bart

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