Search Results - "Siegmund, K."

Comprehensive epigenomic profiling of human alveolar epithelial differentiation identifies key epigenetic states and transcription factor co-regulatory networks for maintenance of distal lung identity by Zhou, B, Stueve, T R, Mihalakakos, E A, Miao, L, Mullen, D, Wang, Y, Liu, Y, Luo, J, Tran, E, Siegmund, K D, Lynch, S K, Ryan, A L, Offringa, I A, Borok, Z, Marconett, C N

“…Disruption of alveolar epithelial cell (AEC) differentiation is implicated in distal lung diseases such as chronic obstructive pulmonary disease, idiopathic…”
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DNA methylation profiles in diffuse large B-cell lymphoma and their relationship to gene expression status by Pike, B L, Greiner, T C, Wang, X, Weisenburger, D D, Hsu, Y-H, Renaud, G, Wolfsberg, T G, Kim, M, Weisenberger, D J, Siegmund, K D, Ye, W, Groshen, S, Mehrian-Shai, R, Delabie, J, Chan, W C, Laird, P W, Hacia, J G

“…In an initial epigenetic characterization of diffuse large B-cell lymphoma (DLBCL), we evaluated the DNA methylation levels of over 500 CpG islands. Twelve CpG…”
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1089 Intravital Microscopy Identifies Antibody-dependent Phagocytosis by Macrophages as Main Effector Mechanism to Prevent Development of Liver Metastases by Gul, N, Siegmund, K, Bogels, M, Braster, R, Vidarsson, G, Kubes, P, van Egmond, M

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Association of breast cancer DNA methylation profiles with hormone receptor status and response to tamoxifen by WIDSCHWENDTER, Martin, SIEGMUND, Kimberly D, MÜLLER, Hannes M, FIEGL, Heidi, MARTH, Christian, MÜLLER-HOLZNER, Elisabeth, JONES, Peter A, LAIRD, Peter W

“…We have generated DNA methylation profiles of 148 human breast tumors and found significant differences in hormone receptor (HR) status between clusters of DNA…”
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Testing Linkage Disequilibrium in Sibships by Siegmund, Kimberly D., Langholz, Bryan, Kraft, Peter, Thomas, Duncan C.

“…We describe the use of multivariate regression for testing allelic association in the presence of linkage, using marker genotype data from sibships. The test…”
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The Methylenetetrahydrofolate Reductase 677C→T Polymorphism and Distal Colorectal Adenoma Risk by LEVINE, A. J, SIEGMUND, K. D, ERVIN, C. M, DIEP, A, LEE, E. R, FRANKL, H. D, HAILE, R. W

“…A common polymorphism in the methylenetetrahydrofolate reductase ( MTHFR ) gene, where a cytosine at nucleotide 677 is replaced by a thymine (677C→T), is…”
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Migration rules: functional properties of naive and effector/memory-like regulatory T cell subsets by Huehn, J, Siegmund, K, Hamann, A

“…Suppressor T cells were first described in the early 1970s, but since the hypothetical soluble suppressor factor could not be identified on a molecular level…”
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The effect of excimer laser photorefractive keratectomy on intraocular pressure measurements using the Goldmann applanation tonometer by Mardelli, P G, Piebenga, L W, Whitacre, M M, Siegmund, K D

“…The authors determined whether photorefractive keratectomy (PRK) affects Goldmann applanation readings in human eyes. The intraocular pressure (IOP) of 111…”
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Molecular details of quinolone–DNA interactions: solution structure of an unusually stable DNA duplex with covalently linked nalidixic acid residues and non-covalent complexes derived from it by Siegmund, Karsten, Maheshwary, Shruti, Narayanan, Sukunath, Connors, William, Riedrich, Matthias, Printz, Michael, Richert, Clemens

“…Quinolones are antibacterial drugs that are thought to bind preferentially to disturbed regions of DNA. They do not fall into the classical categories of…”
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Hostility, social support, and coronary heart disease in the National Heart, Lung, and Blood Institute Family Heart Study by Knox, Sarah S., Siegmund, Kimberly D., Weidner, Gerdi, Ellison, R.Curtis, Adelman, Avril, Paton, Catherine

“…This cross-sectional study investigated the association of hostility and social support to coronary heart disease (CHD) in 2 groups of men and women: those…”
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A broad epigenetic defect of abnormal human sperm is suggested by elevated methylation of numerous DNA sequences in sperm of low concentration, poor morphology and poor motility by Cortessis, V.K, Houshdaran, S, Siegmund, K, Yang, A.S, Laird, P.W, Sokol, R.Z

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Nuclear magnetic and conductivity relaxations by Li diffusion in glassy and crystalline LiAlSi4O10 by Winter, R., Siegmund, K., Heitjans, P.

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Chemotactic responses of IL-4-, IL-10-, and IFN-γ-producing CD4+ T cells depend on tissue origin and microbial stimulus by Debes, G. F., Dahl, M. E., Mahiny, A. J., Bonhagen, K., Campbell, D. J., Siegmund, K., Erb, K. J., Lewis, D. B., Kamradt, T., Hamann, A.

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Lipoprotein(a) interactions with lipid and non-lipid risk factors in patients with early onset coronary artery disease: Results from the NHLBI Family Heart Study by Hopkins, Paul N., Hunt, Steven C., Schreiner, Pamela J., Eckfeldt, John H., Borecki, Ingrid B., Ellison, Curtis R., Williams, Roger R., Siegmund, Kimberly D.

“…Background: A positive interaction between high plasma lipoprotein(a) [Lp(a)] and unfavorable plasma lipid levels has been reported to result in very high risk…”
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Should we consider gene x environment interaction in the hunt for quantitative trait loci? by Gauderman, W J, Morrison, J L, Siegmund, K D

“…We address the question of whether one can obtain increased power for finding a quantitative trait locus (QTL) if a gene x environment (G x E) interaction is…”
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Multistage sampling for disease Family registries by SIEGMUND, K. D, WHITTEMORE, A. S, THOMAS, D. C

“…The objectives of a family-based disease registry range from characterizing measured genetic factors and gene-environment interaction effects to detecting…”
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D28 THE WEB OF OMICS: DNA, RNA, AND PROTEIN MODIFICATIONS: Association Between Dna Methylation In The Axl Gene At Birth And Childhood Respiratory Health by Gao, L, Millstein, J, Siegmund, K, Dubeau, L, Avol, E, Gilliland, F, Breton, C

“…Methods DNA methylation at birth was measured from newborn blood spots using the Illumina HumanMethylation450 array on a subset of 273 children from the…”
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Ascertainment Bias in Family-based Case-Control Studies by Siegmund, Kimberly D., Langholz, Bryan

“…In a family-matched case-control study, a population-based sample of cases is selected from a well-defined geographic region over a fixed period of time. For…”
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A frailty approach for modelling diseases with variable age of onset in families: the NHLBI family heart study by Siegmund, Kimberly D., Todorov, Alexandre A., Province, Michael A.

“…We use frailty models to analyse the effect of latent genetic and environmental risk factors on hazard functions in nuclear families. The approach expresses…”
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Study-Design Issues in the Development of the University of Southern California Consortium's Colorectal Cancer Family Registry by Haile, Robert W., Siegmund, Kimberly D., Gauderman, W. James, Thomas, Duncan C.

“…The University of Southern California Consortium is a participating center in the National Cancer Institute's Collaborative Family Registry for Colorectal…”
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