Search Results - "Sieglaff, Douglas H"

Characterization of Gene Expression Phenotype in Amyotrophic Lateral Sclerosis Monocytes by Zhao, Weihua, Beers, David R, Hooten, Kristopher G, Sieglaff, Douglas H, Zhang, Aijun, Kalyana-Sundaram, Shanker, Traini, Christopher M, Halsey, Wendy S, Hughes, Ashley M, Sathe, Ganesh M, Livi, George P, Fan, Guo-Huang, Appel, Stanley H

“…Amyotrophic lateral sclerosis (ALS) is a common adult-onset neurodegenerative disease characterized by selective loss of upper and lower motor neurons…”
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A Thyroid Hormone Receptor/KLF9 Axis in Human Hepatocytes and Pluripotent Stem Cells by Cvoro, Aleksandra, Devito, Liani, Milton, Flora A., Noli, Laila, Zhang, Aijun, Filippi, Celine, Sakai, Keiko, Suh, Ji Ho, H. Sieglaff, Douglas, Dhawan, Anil, Sakai, Takao, Ilic, Dusko, Webb, Paul

“…Biological processes require close cooperation of multiple transcription factors that integrate different signals. Thyroid hormone receptors (TRs) induce…”
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Gonadal Ecdysteroidogenesis in Arthropoda: Occurrence and Regulation by Brown, Mark R, Sieglaff, Douglas H, Rees, Huw H

“…Ecdysteroids are multifunctional hormones in male and female arthropods and are stored in oocytes for use during embryogenesis. Ecdysteroid biosynthesis and…”
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SIRT1 is a direct coactivator of thyroid hormone receptor β1 with gene-specific actions by Suh, Ji Ho, Sieglaff, Douglas H, Zhang, Aijun, Xia, Xuefeng, Cvoro, Aleksandra, Winnier, Glenn E, Webb, Paul

“…Sirtuin 1 (SIRT1) NAD(+)-dependent deacetylase regulates energy metabolism by modulating expression of genes involved in gluconeogenesis and other liver…”
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Ligand Independent and Subtype-Selective Actions of Thyroid Hormone Receptors in Human Adipose Derived Stem Cells by Cvoro, Aleksandra, Bajic, Aleksandar, Zhang, Aijun, Simon, Marisa, Golic, Igor, Sieglaff, Douglas H, Maletic-Savatic, Mirjana, Korac, Aleksandra, Webb, Paul

“…Thyroid hormone (TH) receptors (TRs α and β) are homologous ligand-dependent transcription factors (TFs). While the TRs display distinct actions in…”
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Gene specific actions of thyroid hormone receptor subtypes by Lin, Jean Z, Sieglaff, Douglas H, Yuan, Chaoshen, Su, Jing, Arumanayagam, Anithachristy S, Firouzbakht, Sharareh, Cantu Pompa, Jaime J, Reynolds, Frances Denoto, Zhou, Xiabo, Cvoro, Aleksandra, Webb, Paul

“…There are two homologous thyroid hormone (TH) receptors (TRs α and β), which are members of the nuclear hormone receptor (NR) family. While TRs regulate…”
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Similarities and Distinctions in Actions of Surface-Directed and Classic Androgen Receptor Antagonists by Suh, Ji Ho, Chattopadhyay, Arundhati, Sieglaff, Douglas H, Storer Samaniego, Cheryl, Cox, Marc B, Webb, Paul

“…The androgen receptor (AR) surface-directed antagonist MJC13 inhibits AR function and proliferation of prostate cancer (PC) cells. These effects are related to…”
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Discovering regulatory motifs in the Plasmodium genome using comparative genomics by Wu, Jie, Sieglaff, Douglas H., Gervin, Joshua, Xie, Xiaohui S.

“…Motivation: Understanding gene regulation in Plasmodium, the causative agent of malaria, is an important step in deciphering its complex life cycle as well as…”
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Comparative Genomics Allows the Discovery of Cis-Regulatory Elements in Mosquitoes by Sieglaff, Douglas H., Dunn, W. Augustine, Xie, Xiaohui S., Megy, Karyn, Marinotti, Osvaldo, James, Anthony A.

“…The discovery and mapping of cis-regulatory elements is important for understanding regulation of gene transcription in mosquito vectors of human diseases…”
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Forkhead transcription factors regulate mosquito reproduction by Hansen, Immo A., Sieglaff, Douglas H., Munro, James B., Shiao, Shin-Hong, Cruz, Josefa, Lee, Iris W., Heraty, John M., Raikhel, Alexander S.

“…Forkhead-box (Fox) genes encode a family of transcription factors defined by a ‘winged helix’ DNA-binding domain. In this study we aimed to identify Fox…”
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HBO1 directs histone H4 specific acetylation, potentiating mechano-transduction pathways and membrane elasticity in ovarian cancer cells by Quintela, Marcos, Sieglaff, Douglas H., Gazze, Andrea Salvatore, Zhang, Aijun, Gonzalez, Deyarina, Francis, Lewis, Webb, Paul, Conlan, R. Steven

“…New approaches to treat ovarian cancer, the fifth leading cause of cancer mortality among women, are being sought, with the targeting of epigenetic modulators…”
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Role of RPL39 in Metaplastic Breast Cancer by Dave, Bhuvanesh, Gonzalez, Daniel D, Liu, Zhi-Bin, Li, Xiaoxian, Wong, Helen, Granados, Sergio, Ezzedine, Nadeer E, Sieglaff, Douglas H, Ensor, Joe E, Miller, Kathy D, Radovich, Milan, KarinaEtrovic, Agda, Gross, Steven S, Elemento, Olivier, Mills, Gordon B, Gilcrease, Michael Z, Chang, Jenny C

“…Metaplastic breast cancer is one of the most therapeutically challenging forms of breast cancer because of its highly heterogeneous and chemoresistant nature…”
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Thyroid hormone receptor regulates most genes independently of fibroblast growth factor 21 in liver by Zhang, Aijun, Sieglaff, Douglas H, York, Jean Philippe, Suh, Ji Ho, Ayers, Stephen D, Winnier, Glenn E, Kharitonenkov, Alexei, Pin, Christopher, Zhang, Pumin, Webb, Paul, Xia, Xuefeng

“…Thyroid hormone (TH) acts through specific receptors (TRs), which are conditional transcription factors, to induce fibroblast growth factor 21 (FGF21), a…”
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Mechanisms of peroxisome proliferator activated receptor γ regulation by non-steroidal anti-inflammatory drugs by Puhl, Ana C, Milton, Flora A, Cvoro, Aleksandra, Sieglaff, Douglas H, Campos, Jéssica C L, Bernardes, Amanda, Filgueira, Carly S, Lindemann, Jan Lammel, Deng, Tuo, Neves, Francisco A R, Polikarpov, Igor, Webb, Paul

“…Non-steroidal anti-inflammatory drugs (NSAIDs) display anti-inflammatory, antipyretic and analgesic properties by inhibiting cyclooxygenases and blocking…”
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PPARγ partial agonist GQ-16 strongly represses a subset of genes in 3T3-L1 adipocytes by Milton, Flora Aparecida, Cvoro, Aleksandra, Amato, Angelica A., Sieglaff, Douglas H., Filgueira, Carly S., Arumanayagam, Anithachristy Sigamani, de Lima, Maria do Carmo Alves, Pitta, Ivan Rocha, de Assis Rocha Neves, Francisco, Webb, Paul

“…Thiazolidinediones (TZDs) are peroxisome proliferator-activated receptor gamma (PPARγ) agonists that improve insulin resistance but trigger side effects such…”
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Nuclear receptors in the mosquito Aedes aegypti: annotation, hormonal regulation and expression profiling by Cruz, Josefa, Sieglaff, Douglas H, Arensburger, Peter, Atkinson, Peter W, Raikhel, Alexander S

“…In anautogenous mosquitoes, egg development requires blood feeding and as a consequence mosquitoes act as vectors of numerous devastating diseases of humans…”
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Nuclear receptors in the mosquito Aedes aegypti by Cruz, Josefa, Sieglaff, Douglas H, Arensburger, Peter, Atkinson, Peter W, Raikhel, Alexander S

“…In anautogenous mosquitoes, egg development requires blood feeding and as a consequence mosquitoes act as vectors of numerous devastating diseases of humans…”
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Expression of genes encoding proteins involved in ecdysteroidogenesis in the female mosquito, Aedes aegypti by Sieglaff, Douglas H., Duncan, Kelli Adams, Brown, Mark R.

“…A blood meal induces the ovaries of female Aedes aegypti mosquitoes to produce ecdysteroid hormones that regulate many processes required for egg maturation…”
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Juvenile hormone connects larval nutrition with target of rapamycin signaling in the mosquito Aedes aegypti by Shiao, Shin-Hong, Hansen, Immo A., Zhu, Jinsong, Sieglaff, Douglas H., Raikhel, Alexander S.

“…Anautogenous mosquitoes require blood meals to promote egg development. If adequate nutrients are not obtained during larval development, the resulting “small”…”
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Identical Gene Regulation Patterns of T3 and Selective Thyroid Hormone Receptor Modulator GC-1 by Yuan, Chaoshen, Lin, Jean Z.H, Sieglaff, Douglas H, Ayers, Steven D, DeNoto-Reynolds, Frances, Baxter, John D, Webb, Paul

“…Synthetic selective thyroid hormone (TH) receptor (TR) modulators (STRM) exhibit beneficial effects on dyslipidemias in animals and humans and reduce obesity,…”
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