Search Results - "Siegfried, Kellee R."

Dmrt1 is necessary for male sexual development in zebrafish by Webster, Kaitlyn A., Schach, Ursula, Ordaz, Angel, Steinfeld, Jocelyn S., Draper, Bruce W., Siegfried, Kellee R.

“…The dmrt1 (doublesex and mab-3 related transcription factor 1) gene is a key regulator of sex determination and/or gonadal sex differentiation across metazoan…”
Get full text

Germ cells in the teleost fish medaka have an inherent feminizing effect by Nishimura, Toshiya, Yamada, Kazuki, Fujimori, Chika, Kikuchi, Mariko, Kawasaki, Toshihiro, Siegfried, Kellee R, Sakai, Noriyoshi, Tanaka, Minoru

“…Germ cells are the only cells that can transfer genetic materials to the next generation via the sperm or egg. However, recent analyses in teleosts revealed…”
Get full text

Germ line control of female sex determination in zebrafish by Siegfried, Kellee R., Nüsslein-Volhard, Christiane

“…A major transition during development of the gonad is commitment from an undifferentiated “bi-potential” state to ovary or testis fate. In mammals, the oogonia…”
Get full text

Polygenic sex determination system in zebrafish by Liew, Woei Chang, Bartfai, Richard, Lim, Zijie, Sreenivasan, Rajini, Siegfried, Kellee R, Orban, Laszlo

“…Despite the popularity of zebrafish as a research model, its sex determination (SD) mechanism is still unknown. Most cytogenetic studies failed to find…”
Get full text

It starts at the ends: The zebrafish meiotic bouquet is where it all begins by Siegfried, Kellee R

“…To accomplish this, meiotic germ cells duplicate their genome one time followed by two rounds of cell division (meiosis I and II) to produce haploid gametes…”
Get full text

FOXA2 rewires AP-1 for transcriptional reprogramming and lineage plasticity in prostate cancer by Wang, Zifeng, Townley, Scott L., Zhang, Songqi, Liu, Mingyu, Li, Muqing, Labaf, Maryam, Patalano, Susan, Venkataramani, Kavita, Siegfried, Kellee R., Macoska, Jill A., Han, Dong, Gao, Shuai, Risbridger, Gail P., Taylor, Renea A., Lawrence, Mitchell G., He, Housheng Hansen, Selth, Luke A., Cai, Changmeng

“…FOXA family proteins act as pioneer factors by remodeling compact chromatin structures. FOXA1 is crucial for the chromatin binding of the androgen receptor…”
Get full text

Efficient mapping and cloning of mutations in zebrafish by low-coverage whole-genome sequencing by Bowen, Margot E, Henke, Katrin, Siegfried, Kellee R, Warman, Matthew L, Harris, Matthew P

“…The generation and analysis of mutants in zebrafish has been instrumental in defining the genetic regulation of vertebrate development, physiology, and…”
Get full text

Minibrain and Wings apart control organ growth and tissue patterning through down-regulation of Capicua by Yang, Liu, Paul, Sayantanee, Trieu, Kenneth G., Dent, Lucas G., Froldi, Francesca, Forés, Marta, Webster, Kaitlyn, Siegfried, Kellee R., Kondo, Shu, Harvey, Kieran, Cheng, Louise, Jiménez, Gerardo, Shvartsman, Stanislav Y., Veraksa, Alexey

“…The transcriptional repressor Capicua (Cic) controls tissue patterning and restricts organ growth, and has been recently implicated in several cancers. Cic has…”
Get full text

A new and improved algorithm for the quantification of chromatin condensation from microscopic data shows decreased chromatin condensation in regenerating axolotl limb cells by Sosnik, Julian, Vieira, Warren A, Webster, Kaitlyn A, Siegfried, Kellee R, McCusker, Catherine D

“…The nuclear landscape plays an important role in the regulation of tissue and positional specific genes in embryonic and developing cells. Changes in this…”
Get full text

A K+-selective CNG channel orchestrates Ca2+ signalling in zebrafish sperm by Fechner, Sylvia, Alvarez, Luis, Bönigk, Wolfgang, Müller, Astrid, Berger, Thomas K, Pascal, Rene, Trötschel, Christian, Poetsch, Ansgar, Stölting, Gabriel, Siegfried, Kellee R, Kremmer, Elisabeth, Seifert, Reinhard, Kaupp, U Benjamin

“…Calcium in the flagellum controls sperm navigation. In sperm of marine invertebrates and mammals, Ca2+ signalling has been intensely studied, whereas for fish…”
Get full text

Isolation and cytogenetic characterization of zebrafish meiotic prophase I mutants by Saito, Kenji, Siegfried, Kellee R., Nüsslein‐Volhard, Christiane, Sakai, Noriyoshi

“…We describe here the isolation and cytogenetic characterization of three meiotic prophase I mutants, denoted ietsugu (its), iesada (isa), and iemochi (imo),…”
Get full text

POP-1 controls axis formation during early gonadogenesis in C. elegans by Siegfried, Kellee R, Kimble, Judith

“…The shape and polarity of the C. elegans gonad is defined during early gonadogenesis by two somatic gonadal precursor cells, Z1 and Z4, and their descendants…”
Get full text

Histological Analysis of Gonads in Zebrafish by Siegfried, Kellee R, Steinfeld, Jocelyn S

“…Zebrafish is an excellent system for the study of gonad development due to available genetic tools and its utilization as a human disease model. The zebrafish…”
Get more information

Differentiation of zebrafish spermatogonial stem cells to functional sperm in culture by Kawasaki, Toshihiro, Siegfried, Kellee R, Sakai, Noriyoshi

“…Molecular dissection and chemical screening on a complex process such as spermatogenesis could be facilitated by cell culture approaches that allow easy access…”
Get full text

SETD7 functions as a transcription repressor in prostate cancer via methylating FOXA1 by Wang, Zifeng, Petricca, Jessica, Liu, Mingyu, Zhang, Songqi, Chen, Sujun, Li, Muqing, Besschetnova, Anna, Patalano, Susan, Venkataramani, Kavita, Siegfried, Kellee R, Macoska, Jill A, Han, Dong, Gao, Shuai, Vedadi, Masoud, Arrowsmith, Cheryl H, He, Housheng Hansen, Cai, Changmeng

“…Dysregulation of histone lysine methyltransferases and demethylases is one of the major mechanisms driving the epigenetic reprogramming of transcriptional…”
Get full text

Cyclin-dependent kinase 21 is a novel regulator of proliferation and meiosis in the male germline of zebrafish by Webster, Kaitlyn A, Henke, Katrin, Ingalls, Delaney M, Nahrin, Adeeba, Harris, Matthew P, Siegfried, Kellee R

“…Germ cell differentiation and maintenance relies on complex regulation of mitotic and meiotic progression. Cyclin-dependent kinases (CDKs) and their activating…”
Get full text

Androgen receptor splice variants drive castrationresistant prostate cancer metastasis by activating distinct transcriptional programs by Han, Dong, Labaf, Maryam, Zhao, Yawei, Owiredu, Jude, Zhang, Songqi, Patel, Krishna, Venkataramani, Kavita, Steinfeld, Jocelyn S, Han, Wanting, Li, Muqing, Liu, Mingyu, Wang, Zifeng, Besschetnova, Anna, Patalano, Susan, Mulhearn, Michaela J, Macoska, Jill A, Yuan, Xin, Balk, Steven R, Nelson, Peter S, Plymate, Stephen R, Gao, Shuai, Siegfried, Kellee R, Liu, Ruihua, Stangis, Mary M, Foxa, Gabrielle, Czernik, Piotr J, Williams, Bart O, Zarringhalam, Kourosh, Li, Xiaohong, Cai, Changmeng

“…One critical mechanism through which prostate cancer (PCa) adapts to treatments targeting androgen receptor (AR) signaling is the emergence of ligand-binding…”
Get full text

Androgen receptor splice variants drive castration-resistant prostate cancer metastasis by activating distinct transcriptional programs by Han, Dong, Labaf, Maryam, Zhao, Yawei, Owiredu, Jude, Zhang, Songqi, Patel, Krishna, Venkataramani, Kavita, Steinfeld, Jocelyn S, Han, Wanting, Li, Muqing, Liu, Mingyu, Wang, Zifeng, Besschetnova, Anna, Patalano, Susan, Mulhearn, Michaela J, Macoska, Jill A, Yuan, Xin, Balk, Steven P, Nelson, Peter S, Plymate, Stephen R, Gao, Shuai, Siegfried, Kellee R, Liu, Ruihua, Stangis, Mary M, Foxa, Gabrielle, Czernik, Piotr J, Williams, Bart O, Zarringhalam, Kourosh, Li, Xiaohong, Cai, Changmeng

“…One critical mechanism through which prostate cancer (PCa) adapts to treatments targeting androgen receptor (AR) signaling is the emergence of ligand-binding…”
Get full text

Susceptibility-Associated Genetic Variation in NEDD9 Contributes to Prostate Cancer Initiation and Progression by Han, Dong, Owiredu, Jude N, Healy, Bridget M, Li, Muqing, Labaf, Maryam, Steinfeld, Jocelyn S, Patalano, Susan, Gao, Shuai, Liu, Mingyu, Macoska, Jill A, Zarringhalam, Kourosh, Siegfried, Kellee R, Yuan, Xin, Rebbeck, Timothy R, Cai, Changmeng

“…Although American men of European ancestry represent the largest population of patients with prostate cancer, men of African ancestry are disproportionately…”
Get full text

Genetic tools for the study of the mangrove killifish, Kryptolebias marmoratus, an emerging vertebrate model for phenotypic plasticity by Li, Cheng‐Yu, Boldt, Helena, Parent, Emily, Ficklin, Jax, James, Althea, Anlage, Troy J., Boyer, Lena M., Pierce, Brianna R., Siegfried, Kellee R., Harris, Matthew P., Haag, Eric S.

“…Kryptolebias marmoratus (Kmar), a teleost fish of the order Cyprinodontiformes, has a suite of unique phenotypes and behaviors not observed in other fishes…”
Get full text