Search Results - "Siegele, Bradford"

Laboratory testing in BCR‐ABL1‐like (Philadelphia‐like) B‐lymphoblastic leukemia/lymphoma by Siegele, Bradford J., Nardi, Valentina

“…BCR‐ABL1‐like B‐lymphoblastic leukemia/lymphoma (BCR‐ABL1‐like B‐ALL), also known as Philadelphia‐like (Ph‐like) ALL, is a neoplasm of B‐lineage lymphoblasts…”
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DUX4 Immunohistochemistry Is a Highly Sensitive and Specific Marker for CIC-DUX4 Fusion-positive Round Cell Tumor by Siegele, Bradford, Roberts, Jon, Black, Jennifer O, Rudzinski, Erin, Vargas, Sara O, Galambos, Csaba

“…The histologic differential diagnosis of pediatric and adult round cell tumors is vast and includes the recently recognized entity CIC-DUX4 fusion-positive…”
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Assembly and activation of the Hippo signalome by FAT1 tumor suppressor by Martin, Daniel, Degese, Maria S., Vitale-Cross, Lynn, Iglesias-Bartolome, Ramiro, Valera, Juan Luis Callejas, Wang, Zhiyong, Feng, Xiaodong, Yeerna, Huwate, Vadmal, Vachan, Moroishi, Toshiro, Thorne, Rick F., Zaida, Moraima, Siegele, Bradford, Cheong, Sok C., Molinolo, Alfredo A., Samuels, Yardena, Tamayo, Pablo, Guan, Kun Liang, Lippman, Scott M., Lyons, J. Guy, Gutkind, J. Silvio

“…Dysregulation of the Hippo signaling pathway and the consequent YAP1 activation is a frequent event in human malignancies, yet the underlying molecular…”
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Multi-gene measurable residual disease assessed by digital polymerase chain reaction has clinical and biological utility in acute myeloid leukemia patients receiving venetoclax/azacitidine by Winters, Amanda C, Minhajuddin, Mohd, Stevens, Brett M, Major, Ajay, Bosma, Grace, Abbott, Diana, Miltgen, Nicholas, Yuan, Ji, Treece, Amy L, Siegele, Bradford J, Ewalt, Mark D, Gutman, Jonathan A, Jordan, Craig T, Pollyea, Daniel A

“…Venetoclax with azacitidine (ven/aza) is a lower-intensity therapeutic regimen that has been shown to improve outcomes in elderly patients with acute myeloid…”
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Real-world experience of venetoclax with azacitidine for untreated patients with acute myeloid leukemia by Winters, Amanda C., Gutman, Jonathan A., Purev, Enkhtsetseg, Nakic, Molly, Tobin, Jennifer, Chase, Stephanie, Kaiser, Jeff, Lyle, Lindsey, Boggs, Chelsey, Halsema, Keri, Schowinsky, Jeffrey T., Rosser, Julie, Ewalt, Mark D., Siegele, Bradford, Rana, Vishal, Schuster, Steven, Abbott, Diana, Stevens, Brett M., Jordan, Craig T., Smith, Clayton, Pollyea, Daniel A.

“…Venetoclax is approved for older untreated acute myeloid leukemia (AML) patients. Venetoclax was available prior to approval off-label. We assessed our…”
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N‐terminus DUX4‐immunohistochemistry is a reliable methodology for the diagnosis of DUX4‐fused B‐lymphoblastic leukemia/lymphoma (N‐terminus DUX4 IHC for DUX4‐fused B‐ALL) by Siegele, Bradford J., Stemmer‐Rachamimov, Anat O., Lilljebjorn, Henrik, Fioretos, Thoas, Winters, Amanda C., Dal Cin, Paola, Treece, Amy, Gaskell, Alisa, Nardi, Valentina

“…B‐lymphoblastic leukemia/lymphoma (B‐ALL) is the most common pediatric malignancy and the most commonly diagnosed adult lymphoblastic leukemia. Recent advances…”
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Autoreactive Antibodies Associated with Castleman Disease Triad by Turner, Jacqueline A., Hakimi, Ali, Lee, Hannah, Schowinsky, Jeffrey T., Sippel, Jeffrey M., Siegele, Bradford J., Torres, Raul M., Robinson, William A.

“…The Castleman triad has been described in a select few patients presenting with a retroperitoneal mass, mucocutaneous pemphigus vulgaris, and bronchiolitis…”
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Case 28-2018: A 39-Year-Old Man with Epistaxis, Pain and Erythema of the Forearm, and Pancytopenia by Iyasere, Christiana A, Takvorian, Ronald W, Simeone, F. Joseph, Siegele, Bradford J

“…A 39-year-old man presented with epistaxis, pain and erythema of the arm, and pancytopenia, with neutropenia and monocytopenia. Imaging studies were notable…”
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Epidermal Growth Factor Receptor ( EGFR ) Mutations in Small Cell Lung Cancers: Two Cases and a Review of the Literature by Siegele, Bradford J, Shilo, Konstantin, Chao, Bo H, Carbone, David, Zhao, Weiqiang, Ioffe, Olga, Franklin, Wilbur A, Edelman, Martin J, Aisner, Dara L

“…Highlights • We report a case of SCLC harboring a novel D855H point mutation in the EGFR gene. • We report a case of SCLC demonstrating a L858R point mutation…”
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Multidisciplinary Fusion: A recurrent expansive prevertebral vascular anomaly with EWSR1::NFATC2 fusion by DeMarsh, Samantha J., Siegele, Bradford, Zavaletta, Vaz, Annam, Aparna, Kulungowski, Ann M., Hill, Lauren R., Donaldson, Nathan, Nakano, Taizo A.

“…The field of vascular anomalies has seen a rapid paradigm shift from descriptive to molecular diagnoses, with DNA-based next-generation sequencing becoming…”
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Cystic cervical teratoma: A diagnostic and management challenge by Wolter, Nikolaus E., MD, MSc, FRCSC, Siegele, Bradford, MD, JD, Cunningham, Michael J., MD, FACS

“…Abstract Cervical teratomas are relatively rare congenital tumors pathologically defined by their three germ cell layer composition. Classically they manifest…”
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Selective Targeting of a Head and Neck Squamous Cell Carcinoma Cell Line by a Translationally-Controlled Herpes Simplex Virus Thymidine Kinase Suicide Gene by Siegele, Bradford J., BA, JD

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Poster 077: Development of an Immunocompetent Rat Model for Squamous Cell Carcinoma of the Head and Neck by Siegele, Bradford J., BA, JD

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A pediatric case of KMT2A -rearranged B-lymphoblastic lymphoma treated with high-risk therapy by Murphy, Lindsey, Siegele, Bradford, Carstens, Billie, Hartman, Lisa, Faulk, Kelly

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eIF4E-Targeted Suicide Gene Therapy in a Minimal Residual Mouse Model for Metastatic Soft-Tissue Head and Neck Squamous Cell Carcinoma Improves Disease-Free Survival by Siegele, Bradford, B.A, Cefalu, Christopher, B.S, Holm, Neal, M.D, Sun, Guang, B.S, Tubbs, Jesse, B.S, Meschonat, Carol, B.S, Odaka, Yoshinobu, B.S, DeBenedetti, Arrigo, Ph.D, Ghali, G.E., D.D.S., M.D, Chu, Quyen, M.D, Michael Mathis, J., Ph.D, Li, Benjamin D.L., M.D

“…Background Translation initiation factor eIF4E unwinds long 5′-untranslated regions of certain tightly regulated mRNAs and, thereby, facilitates their…”
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156. Translation Initiation Factor eIF4E-Targeted Suicide Gene Therapy Following Cytoreductive Surgery Improves Disease Free Survival in a Mouse Soft Tissue Metastasis Model for Head and Neck Squamous Cell Carcinoma by Siegele, Bradford J, Cefalu, Christopher, Holm, Neal, Sun, Guang, Chu, Quyen, Tubbs, Jesse, Meschonat, Carol, Odaka, Yoshinobu, Mathis, J. Michael, Ghali, Ghali E, Li, Benjamin D.L

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Discordance between detection of MYC rearrangement by immunohistochemistry versus fluorescent in situ hybridization in Burkitt lymphoma by Rankin, Alexander W., Siegele, Bradford, Gross, Thomas G.

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Mucoepidermoid carcinoma may be devoid of squamoid cells by immunohistochemistry: expanding the histologic and immunohistochemical spectrum of MAML2‐ rearranged salivary gland tumours by Bishop, Justin A, Thompson, Lester D R, Siegele, Bradford, Gagan, Jeffrey, Mansour, Mena, Chernock, Rebecca D, Rooper, Lisa M

“…Mucoepidermoid carcinoma (MEC) is historically defined by a mix of squamoid, intermediate, and mucous cells, but we have recently encountered several cases…”
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Clinical features and outcomes of patients with Shwachman-Diamond syndrome and myelodysplastic syndrome or acute myeloid leukaemia: a multicentre, retrospective, cohort study by Myers, Kasiani C, Furutani, Elissa, Weller, Edie, Siegele, Bradford, Galvin, Ashley, Arsenault, Valerie, Alter, Blanche P, Boulad, Farid, Bueso-Ramos, Carlos, Burroughs, Lauri, Castillo, Paul, Connelly, James, Davies, Stella M, DiNardo, Courtney D, Hanif, Iftikhar, Ho, Richard H, Karras, Nicole, Manalang, Michelle, McReynolds, Lisa J, Nakano, Taizo A, Nalepa, Grzegorz, Norkin, Maxim, Oberley, Matthew J, Orgel, Etan, Pastore, Yves D, Rosenthal, Joseph, Walkovich, Kelly, Larson, Jordan, Malsch, Maggie, Elghetany, M Tarek, Fleming, Mark D, Shimamura, Akiko

“…Data to inform surveillance and treatment for leukaemia predisposition syndromes are scarce and recommendations are largely based on expert opinion. This study…”
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Primary parotid lymphoma presenting as a recurrent cystic mass: A case report by Rosenblatt, Steven D., Wolter, Nikolaus E., Siegele, Bradford, Brodsky, Jacob R.

“…A 15‐year‐old boy was diagnosed with a cystic parotid mass, which was initially thought to be a first branchial cleft cyst. The mass was treated with…”
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