Search Results - "Siegel, S.J"

Cellular and circuit models of increased resting-state network gamma activity in schizophrenia by White, R.S, Siegel, S.J

“…Highlights • Gamma frequency activity contributes to cognitive function. • Abnormalities in gamma activity are an endophenotype of schizophrenia. • We address…”
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N -methyl- d -aspartic acid receptor antagonist–induced frequency oscillations in mice recreate pattern of electrophysiological deficits in schizophrenia by Ehrlichman, R.S, Gandal, M.J, Maxwell, C.R, Lazarewicz, M.T, Finkel, L.H, Contreras, D, Turetsky, B.I, Siegel, S.J

“…Abstract Introduction: Electrophysiological responses to auditory stimuli have provided a useful means of elucidating mechanisms and evaluating treatments in…”
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Rolipram: A specific phosphodiesterase 4 inhibitor with potential antipsychotic activity by Kanes, S.J, Tokarczyk, J, Siegel, S.J, Bilker, W, Abel, T, Kelly, M.P

“…Abstract Currently available antipsychotic medications work primarily by antagonizing D2 dopamine receptors, thus raising intracellular cAMP levels. We…”
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Ceftriaxone reverses ketamine-induced lasting EEG and astrocyte alterations in juvenile mice by Dodman, K, Featherstone, R.E, Bang, J, Liang, Y, Siegel, S.J

“…Abstract Background Ketamine, an N-methyl- d -aspartate receptor antagonist, is used as a pediatric anesthetic because of its favorable safety profile. It is…”
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Dexras1 a unique ras-GTPase interacts with NMDA receptor activity and provides a novel dissociation between anxiety, working memory and sensory gating by Carlson, G.C, Lin, R.E, Chen, Y, Brookshire, B.R, White, R.S, Lucki, I, Siegel, S.J, Kim, S.F

“…Highlights • A deletion of Dexras1 coupled to NMDAR showed no impact on basal anxiety and depression-like levels. • NDMA receptor subunit2A expression was…”
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Juvenile exposure to ketamine causes delayed emergence of EEG abnormalities during adulthood in mice by Featherstone, R.E, Nagy, L.R, Hahn, C.G, Siegel, S.J

“…Abstract Background Increased susceptibility to cognitive impairment or psychosis in adulthood is associated with adolescent drug abuse. Studies in adults have…”
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A novel electrophysiological model of chemotherapy-induced cognitive impairments in mice by Gandal, M.J, Ehrlichman, R.S, Rudnick, N.D, Siegel, S.J

“…Abstract Purpose Chemotherapeutic agents are known to produce persistent cognitive deficits in cancer patients. However, little progress has been made in…”
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Effect of retrieval effort and switching demand on fMRI activation during semantic word generation in schizophrenia by Ragland, J.D, Moelter, S.T, Bhati, M.T, Valdez, J.N, Kohler, C.G, Siegel, S.J, Gur, R.C, Gur, R.E

“…Abstract Verbal fluency deficits in schizophrenia are difficult to interpret because the tasks are multi-factorial and groups differ in total words generated…”
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In vitro and in vivo demonstration of risperidone implants in mice by Rabin, C, Liang, Y, Ehrlichman, R.S, Budhian, A, Metzger, K.L, Majewski-Tiedeken, C, Winey, K.I, Siegel, S.J

“…Abstract Background Non-adherence with medication is a critical limitation in current long-term treatment of schizophrenia and a primary factor in poor…”
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Mecamylamine blocks nicotine-induced enhancement of the P20 auditory event–related potential and evoked gamma by Phillips, J.M, Ehrlichman, R.S, Siegel, S.J

“…Abstract Cigarette smoking is significantly more prevalent in individuals with schizophrenia than in non-affected populations. Certain neurocognitive deficits…”
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Sensory processing in autism spectrum disorders and Fragile X syndrome—From the clinic to animal models by Sinclair, D., Oranje, B., Razak, K.A., Siegel, S.J., Schmid, S.

“…•Sensory information needs to be filtered pre-attentively for the brain to function properly.•Autism spectrum disorder (ASD) and Fragile-X syndrome (FXS) are…”
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Src kinase as a mediator of convergent molecular abnormalities leading to NMDAR hypoactivity in schizophrenia by Banerjee, A, Wang, H-Y, Borgmann-Winter, K E, MacDonald, M L, Kaprielian, H, Stucky, A, Kvasic, J, Egbujo, C, Ray, R, Talbot, K, Hemby, S E, Siegel, S J, Arnold, S E, Sleiman, P, Chang, X, Hakonarson, H, Gur, R E, Hahn, C-G

“…Numerous investigations support decreased glutamatergic signaling as a pathogenic mechanism of schizophrenia, yet the molecular underpinnings for such…”
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The scent of salience — Is there olfactory-trigeminal conditioning in humans? by Moessnang, C., Pauly, K., Kellermann, T., Krämer, J., Finkelmeyer, A., Hummel, T., Siegel, S.J., Schneider, F., Habel, U.

“…Pavlovian fear conditioning has been thoroughly studied in the visual, auditory and somatosensory domain, but evidence is scarce with regard to the…”
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Chronic ketamine impairs fear conditioning and produces long-lasting reductions in auditory evoked potentials by Amann, Laura C, Halene, Tobias B, Ehrlichman, Richard S, Luminais, Stephen N, Ma, Nan, Abel, Ted, Siegel, Steven J

“…Abstract Ketamine is an NMDA receptor antagonist with a variety of uses, ranging from recreational drug to pediatric anesthetic and chronic pain reliever…”
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Monoamine reuptake inhibition and nicotine receptor antagonism reduce amplitude and gating of auditory evoked potentials by Siegel, S.J., Maxwell, C.R., Majumdar, S., Trief, D.F., Lerman, C., Gur, R.E., Kanes, S.J., Liang, Y.

“…Sensory encoding deficits have been extensively studied as endophenotypic markers of schizophrenia using auditory evoked potentials. In order to increase…”
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Mice expressing constitutively active Gsα exhibit stimulus encoding deficits similar to those observed in schizophrenia patients by MAXWELL, C. R, LIANG, Y, KELLY, M. P, KANES, S. J, ABEL, T, SIEGEL, S. J

“…People with schizophrenia display sensory encoding deficits across a broad range of electrophysiological and behavioral measures, suggesting fundamental…”
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Mice expressing constitutively active G sα exhibit stimulus encoding deficits similar to those observed in schizophrenia patients by Maxwell, C.R., Liang, Y., Kelly, M.P., Kanes, S.J., Abel, T., Siegel, S.J.

“…People with schizophrenia display sensory encoding deficits across a broad range of electrophysiological and behavioral measures, suggesting fundamental…”
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Phosphodiesterase inhibitors: A novel mechanism for receptor-independent antipsychotic medications by Maxwell, C.R., Kanes, S.J., Abel, T., Siegel, S.J.

“…OverviewAll current antipsychotic medications work by binding to Gi-coupled dopamine (DA) D2 receptors. Such medications are thought to affect cellular…”
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A method for abbreviating assessment scales: The schizophrenia quality of life scale by Bilker, W.B., Brensinger, C., Kurtz, M., Kohler, C., Gur, R.C., Siegel, S.J., Gur, R.E.

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Effects of social deprivation in prepubescent rhesus monkeys: immunohistochemical analysis of the neurofilament protein triplet in the hippocampal formation by Siegel, S J, Ginsberg, S D, Hof, P R, Foote, S L, Young, W G, Kraemer, G W, McKinney, W T, Morrison, J H

“…Social deprivation during early postnatal life has profound and long-lasting effects on the behavior of primates, including prolonged and exaggerated responses…”
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