Search Results - "Siegel, Richard"

Beyond TNF: TNF superfamily cytokines as targets for the treatment of rheumatic diseases by Croft, Michael, Siegel, Richard M.

“…Key Points TNF inhibitors are among the most effective protein-based drugs for reducing inflammation associated with several rheumatic diseases In addition to…”
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Commentary on Recurrent Hypoglycemic Episodes with Hypoinsulinemia in a Patient with Diabetes by Siegel, Richard D

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Structural Basis and Functional Role of Intramembrane Trimerization of the Fas/CD95 Death Receptor by Fu, Qingshan, Fu, Tian-Min, Cruz, Anthony C., Sengupta, Prabuddha, Thomas, Stacy K., Wang, Shuqing, Siegel, Richard M., Wu, Hao, Chou, James J.

“…Fas (CD95, Apo-1, or TNFRSF6) is a prototypical apoptosis-inducing death receptor in the tumor necrosis factor receptor (TNFR) superfamily. While the…”
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Mitochondrial ROS Fire Up T Cell Activation by Murphy, Michael P., Siegel, Richard M.

“…Metabolic reprogramming has emerged as an important feature of immune cell activation. Two new studies, including Sena et al. (2013) in this issue of Immunity,…”
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Cryo-EM Structure of Caspase-8 Tandem DED Filament Reveals Assembly and Regulation Mechanisms of the Death-Inducing Signaling Complex by Fu, Tian-Min, Li, Yang, Lu, Alvin, Li, Zongli, Vajjhala, Parimala R., Cruz, Anthony C., Srivastava, Devendra B., DiMaio, Frank, Penczek, Pawel A., Siegel, Richard M., Stacey, Katryn J., Egelman, Edward H., Wu, Hao

“…Caspase-8 activation can be triggered by death receptor-mediated formation of the death-inducing signaling complex (DISC) and by the inflammasome adaptor ASC…”
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Mitochondrial reactive oxygen species promote production of proinflammatory cytokines and are elevated in TNFR1-associated periodic syndrome (TRAPS) by Bulua, Ariel C, Simon, Anna, Maddipati, Ravikanth, Pelletier, Martin, Park, Heiyoung, Kim, Kye-Young, Sack, Michael N, Kastner, Daniel L, Siegel, Richard M

“…Reactive oxygen species (ROS) have an established role in inflammation and host defense, as they kill intracellular bacteria and have been shown to activate…”
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A new class of doped nanobulk high-figure-of-merit thermoelectrics by scalable bottom-up assembly by Mehta, Rutvik J., Zhang, Yanliang, Karthik, Chinnathambi, Singh, Binay, Siegel, Richard W., Borca-Tasciuc, Theodorian, Ramanath, Ganpati

“…Obtaining thermoelectric materials with high figure of merit ZT is an exacting challenge because it requires the independent control of electrical…”
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Effect of gold nanoparticle morphology on adsorbed protein structure and function by Gagner, Jennifer E, Lopez, Marimar D, Dordick, Jonathan S, Siegel, Richard W

“…Abstract Many biomedical applications of gold nanoparticles (NPs) rely on proteins that are covalently attached or adsorbed on the NP surface. The biological…”
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Implementation of a pharmacist-led weight loss service to improve medication access and weight loss by Schermerhorn, Samantha, Aurora, John, McElligott, Meghan, Siegel, Richard D.

“…Obesity is a prevalent medical condition that can contribute to an increased risk of developing serious comorbidities, leading to an increase in…”
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Caspases at the crossroads of immune-cell life and death by Siegel, Richard M

“…Caspases are responsible for crucial aspects of inflammation and immune-cell death that are disrupted in a number of genetic autoimmune and autoinflammatory…”
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Critical role of fatty acid metabolism in ILC2-mediated barrier protection during malnutrition and helminth infection by Wilhelm, Christoph, Harrison, Oliver J, Schmitt, Vanessa, Pelletier, Martin, Spencer, Sean P, Urban, Jr, Joseph F, Ploch, Michelle, Ramalingam, Thirumalai R, Siegel, Richard M, Belkaid, Yasmine

“…Innate lymphoid cells (ILC) play an important role in many immune processes, including control of infections, inflammation, and tissue repair. To date, little…”
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Lighting the fires within: the cell biology of autoinflammatory diseases by Park, Heiyoung, Bourla, Ariel Bulua, Kastner, Daniel L., Colbert, Robert A., Siegel, Richard M.

“…Key Points Autoinflammatory diseases are marked by uncontrolled inflammation in the absence of autoantibodies or autoreactive T cell responses. The genetic…”
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Beyond Cell Death: New Functions for TNF Family Cytokines in Autoimmunity and Tumor Immunotherapy by Yi, Fei, Frazzette, Nicholas, Cruz, Anthony C., Klebanoff, Christopher A., Siegel, Richard M.

“…Originally discovered as an inducer of apoptosis, the TNF-family receptor Fas (CD95, APO-1, TNFRSF6) has more recently been found to have functions beyond cell…”
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Low-density granulocytes activate T cells and demonstrate a non-suppressive role in systemic lupus erythematosus by Rahman, Saifur, Sagar, Divya, Hanna, Richard N, Lightfoot, Yaima L, Mistry, Pragnesh, Smith, Carolyne K, Manna, Zerai, Hasni, Sarfaraz, Siegel, Richard M, Sanjuan, Miguel A, Kolbeck, Roland, Kaplan, Mariana J, Casey, Kerry A

“…The presence of proinflammatory low-density granulocytes (LDG) has been demonstrated in autoimmune and infectious diseases. Recently, regulatory neutrophilic…”
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TNF leads to mtDNA release and cGAS/STING-dependent interferon responses that support inflammatory arthritis by Willemsen, Joschka, Neuhoff, Marie-Therese, Hoyler, Thomas, Noir, Emma, Tessier, Clemence, Sarret, Sophie, Thorsen, Tara N., Littlewood-Evans, Amanda, Zhang, Juan, Hasan, Maroof, Rush, James S., Guerini, Danilo, Siegel, Richard M.

“…Tumor necrosis factor (TNF) is a key driver of several inflammatory diseases, such as rheumatoid arthritis, inflammatory bowel disease, and psoriasis, in which…”
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Prolonged fasting suppresses mitochondrial NLRP3 inflammasome assembly and activation via SIRT3-mediated activation of superoxide dismutase 2 by Traba, Javier, Geiger, Sarah S., Kwarteng-Siaw, Miriam, Han, Kim, Ra, One Hyuk, Siegel, Richard M., Gius, David, Sack, Michael N.

“…Twenty-four hours of fasting is known to blunt activation of the human NLRP3 inflammasome. This effect might be mediated by SIRT3 activation, controlling…”
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TL1A and DR3, a TNF family ligand-receptor pair that promotes lymphocyte costimulation, mucosal hyperplasia, and autoimmune inflammation by Meylan, Françoise, Richard, Arianne C., Siegel, Richard M.

“…DR3 (TNFRSF25) is a member of the tumor necrosis factor receptor (TNFR) superfamily expressed primarily on lymphocytes and is a receptor for the TNF family…”
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TNF superfamily cytokines in the promotion of Th9 differentiation and immunopathology by Meylan, Françoise, Siegel, Richard M.

“…The tumor necrosis factor (TNF) receptors and their corresponding cytokine ligands have been implicated in many aspects of the biology of immune functions. TNF…”
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Chrono‐immunology: progress and challenges in understanding links between the circadian and immune systems by Geiger, Sarah S., Fagundes, Caio T., Siegel, Richard M.

“…Summary Development of inflammatory diseases, such as metabolic syndrome and cancer, is prevalent in individuals that encounter continuous disruption of their…”
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Fasting and refeeding differentially regulate NLRP3 inflammasome activation in human subjects by Traba, Javier, Kwarteng-Siaw, Miriam, Okoli, Tracy C, Li, Jessica, Huffstutler, Rebecca D, Bray, Amanda, Waclawiw, Myron A, Han, Kim, Pelletier, Martin, Sauve, Anthony A, Siegel, Richard M, Sack, Michael N

“…Activation of the NLRP3 inflammasome is associated with metabolic dysfunction, and intermittent fasting has been shown to improve clinical presentation of…”
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