Search Results - "Siegel, R L"

Trypanosomes lacking trypanothione reductase are avirulent and show increased sensitivity to oxidative stress by Krieger, S., Schwarz, W., Ariyanayagam, M. R., Fairlamb, A. H., Krauth‐Siegel, R. L., Clayton, C.

“…In Kinetoplastida, trypanothione and trypanothione reductase (TRYR) provide an intracellular reducing environment, substituting for the glutathione–glutathione…”
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Development and validation of the Self-Esteem And Relationship (SEAR) questionnaire in erectile dysfunction by CAPPELLERI, J. C, ALTHOF, S. E, SIEGEL, R. L, SHPILSKY, A, BELL, S. S, DUTTAGUPTA, S

“…Development and validation of a patient-reported measure of psychosocial variables in men with erectile dysfunction (ED) is described. Literature review, focus…”
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Quality of life, mood, and sexual function: a path analytic model of treatment effects in men with erectile dysfunction and depressive symptoms by ROSEN, R. C, SEIDMAN, S. N, MENZA, M. A, SHABSIGH, R, ROOSE, S. P, TSENG, L. J, ORAZEM, J, SIEGEL, R. L

“…Erectile dysfunction (ED) is commonly associated with depressed mood and diminished quality of life (QoL), but few studies have investigated the causal…”
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2,3-Diphenyl-1,4-Naphthoquinone: A Potential Chemotherapeutic Agent Against Trypanosoma cruzi by Ramos, Enrique I, Garza, Kristine M, Krauth-Siegel, R. L, Bader, Julia, Martinez, Luiz E, Maldonado, Rosa A

“…Chagas disease, caused by Trypanosoma cruzi, is a widespread infection in Latin America. Currently, only 2 partially effective and highly toxic drugs, i.e.,…”
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2- and 3-Substituted 1,4-Naphthoquinone Derivatives as Subversive Substrates of Trypanothione Reductase and Lipoamide Dehydrogenase from Trypanosoma cruzi:  Synthesis and Correlation between Redox Cycling Activities and in Vitro Cytotoxicity by SALMON-CHEMIN, Laurence, BUISINE, Eric, YARDLEY, Vanessa, KOHLER, Sven, DEBREU, Marie-Ange, LANDRY, Valérie, SERGHERAERT, Christian, CROFT, Simon L., KRAUTH-SIEGEL, R. Luise, DAVIOUD-CHARVET, Elisabeth

“…Trypanothione reductase (TR) is both a valid and an attractive target for the design of new trypanocidal drugs. Starting from menadione, plumbagin, and…”
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(2,2‘:6‘,2‘ ‘-Terpyridine)platinum(II) Complexes Are Irreversible Inhibitors of Trypanosoma cruzi Trypanothione Reductase But Not of Human Glutathione Reductase by BONSE, Susanne, RICHARDS, Jonathan M., ROSS, Steven A., LOWE, Gordon, KRAUTH-SIEGEL, R. Luise

“…(2,2':6',2"-terpyridine)platinum(II) complexes possess pronounced cytostatic activities against trypanosomes and leishmania. As shown here, the complexes are…”
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Inhibition of Trypanosoma cruzi Trypanothione Reductase by Acridines:  Kinetic Studies and Structure−Activity Relationships by Bonse, Susanne, Santelli-Rouvier, Christiane, Barbe, Jacques, Krauth-Siegel, R. Luise

“…Series of 9-amino and 9-thioacridines have been synthesized and studied as inhibitors of trypanothione reductase (TR) from Trypanosoma cruzi, the causative…”
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Early sildenafil dose optimization and personalized instruction improves the frequency, flexibility, and success of sexual intercourse in men with erectile dysfunction by STEIDLE, C. P, MCCULLOUGH, A. R, KAMINETSKY, J. C, CROWLEY, A. R, SIEGEL, R. L, DERIESTHAL, H, TSENG, L.-J

“…We investigated the effect of early sildenafil dose optimization and personalized instructions on sexual intercourse success in 1109 men beginning sildenafil…”
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Relationship between patient self-assessment of erectile function and the erectile function domain of the international index of erectile function by Cappelleri, Joseph C, Siegel, Richard L, Osterloh, Ian H, Rosen, Raymond C

“…Objectives. To assess the validity of severity classes on the erectile function (EF) domain of the International Index of Erectile Function by determining…”
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Efficacy of Sildenafil Citrate for the Treatment of Erectile Dysfunction in Men Taking Serotonin Reuptake Inhibitors by Nurnberg, H. George, Gelenberg, Alan, Hargreave, Timothy B., Harrison, Wilma M., Siegel, Richard L., Smith, Michael D.

“…OBJECTIVE: This study was an evaluation of whether sildenafil citrate is effective for the treatment of erectile dysfunction in men taking concomitant…”
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Nitrofuran drugs as common subversive substrates of Trypanosoma cruzi lipoamide dehydrogenase and trypanothione reductase by Blumenstiel, Klaus, Schöneck, Ralf, Yardley, Vanessa, Croft, Simon L., Krauth-Siegel, R.Luise

“…Lipoamide dehydrogenase (LipDH), trypanothione reductase (TR), and glutathione reductase (GR) catalyze the NAD(P)H-dependent reduction of disulfide substrates…”
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Ajoene Is an Inhibitor and Subversive Substrate of Human Glutathione Reductase and Trypanosoma cruzi Trypanothione Reductase:  Crystallographic, Kinetic, and Spectroscopic Studies by Gallwitz, Helge, Bonse, Susanne, Martinez-Cruz, Alfonso, Schlichting, Ilme, Schumacher, Karin, Krauth-Siegel, R. Luise

“…Ajoene ((E,Z)-4,5,9-trithiadodeca-1,6,11-triene 9-oxide), a garlic-derived natural compound, is a covalent inhibitor as well as a substrate of human…”
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Safety and efficacy of doxazosin in benign prostatic hyperplasia: A pooled analysis of three double-blind, placebo-controlled studies by Roehrborn, Claus G., Siegel, Richard L.

“…Abstract To present the results of a pooled analysis of three double-blind, placebo-controlled studies of doxazosin in benign prostatic hyperplasia (BPH)…”
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Alliance not compliance: a philosophy of outpatient care by Frank, E, Kupfer, D J, Siegel, L R

“…Over the last decade, our clinical research team has evolved effective methods for forming a strong treatment alliance with mood disorder patients. These…”
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A multicenter, community-based study of doxazosin in the treatment of concomitant hypertension and symptomatic benign prostatic hyperplasia: the hypertension and BPH intervention trial (HABIT) by Guthrie, Robert M., Siegel, Richard L.

“…As men age, the incidence of both benign prostatic hyperplasia (BPH) and hypertension increases. Concomitant occurrence of these conditions also increases with…”
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Bioinformatic and experimental fishing for artemisinin-interacting proteins from human nasopharyngeal cancer cells by Eichhorn, T, Schloissnig, S, Hahn, B, Wendler, A, Mertens, Rolf, Lehmann, W D, Krauth-Siegel, R L, Efferth, T

“…Determining interacting cellular partners of drugs by chemical proteomic techniques is complex and tedious. Most approaches rely on activity-based probe…”
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Sildenafil (Viagra) prolongs cardiac repolarization by blocking the rapid component of the delayed rectifier potassium current by Butrous, G, Siegel, R L

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Peripheral venous Access ports : Outcomes analysis in 109 patients by BODNER, L. J, NOSHER, J. L, PATEL, K. M, SIEGEL, R. L, BISWAL, R, GRIBBIN, C. E, TOKARZ, R

“…To perform a retrospective outcomes analysis of central venous catheters with peripheral venous access ports, with comparison to published data. One hundred…”
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Endovascular management of ureteroarterial fistula by Feuer, David S., Ciocca, Rocco G., Nackman, Gary B., Siegel, Randall L., Graham, Alan M.

“…Ureteroarterial fistulas, although rare, appear to be increasing in frequency. Because open surgical repair may be difficult and associated with significant…”
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Thiol-based redox metabolism of protozoan parasites by Müller, Sylke, Liebau, Eva, Walter, Rolf D., Krauth-Siegel, R.Luise

“…The review considers redox enzymes of Plasmodium spp., Trypanosomatida, Trichomonas, Entamoeba and Giardia, with special emphasis on their potential use as…”
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