Search Results - "Siegel, Lianne K."
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Estimating reference intervals from an IPD meta-analysis using quantile regression
Published in BMC medical research methodology (26-10-2024)“…Reference intervals, which define an interval in which a specific proportion of measurements from a healthy population are expected to fall, are commonly used…”
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Patient Outcomes and Unit Composition With Transition to a High-Intensity ICU Staffing Model: A Before-and-After Study
Published in Critical care explorations (01-02-2023)“…Provider staffing models for ICUs are generally based on pragmatic necessities and historical norms at individual institutions. A better understanding of the…”
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Acute Appendicitis Treatment Strategies and Mortality Based on Critical Illness on Admission: An Observational Study
Published in Surgical infections (01-02-2024)“…Trials have shown non-inferiority of non-operative management (NOM) for appendicitis, although critically ill patients have been often excluded. The purpose of…”
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Impact of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Vaccination and Booster on Coronavirus Disease 2019 (COVID-19) Symptom Severity Over Time in the COVID-OUT Trial
Published in Clinical infectious diseases (08-02-2023)“…Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination has decreasing protection from acquiring any infection with emergence of new variants;…”
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Abstract MP61: Independent, Joint-Aerobic, and Dose-Response Associations of Resistance Exercise With Cardiovascular Disease Mortality: A Living Meta-Analysis
Published in Circulation (New York, N.Y.) (19-03-2024)“…Abstract only Introduction: Cardiovascular diseases (CVDs) account for ~33% of all deaths globally. Aerobic exercise (AE) is a well-established modifiable risk…”
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Randomized Trial of Metformin, Ivermectin, and Fluvoxamine for Covid-19
Published in The New England journal of medicine (18-08-2022)“…In this trial involving overweight or obese outpatients with Covid-19, investigators found that none of three repurposed drugs (metformin, ivermectin, and…”
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Choice of link functions for generalized linear mixed models in meta-analyses of proportions
Published in Research methods in medicine & health sciences (27-12-2023)“…Two-step approaches for synthesizing proportions in a meta-analysis require first transforming the proportions to a scale where their distribution across…”
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Favorable Antiviral Effect of Metformin on SARS-CoV-2 Viral Load in a Randomized, Placebo-Controlled Clinical Trial of COVID-19
Published in Clinical infectious diseases (16-08-2024)“…Metformin has antiviral activity against RNA viruses including severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The mechanism appears to be…”
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Impact of SARS-CoV-2 vaccination and booster on COVID-19 symptom severity over time in the COVID-OUT trial
Published in Clinical infectious diseases (17-09-2022)“…Vaccination against SARS-CoV-2 was associated with reduced Covid-19 symptom severity in a sample of low to moderate risk adults who were enrolled in an…”
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Bayesian Hierarchical Models for Meta-analysis
Published 01-01-2021“…Meta-analysis is an important and widely used tool for synthesizing information from multiple independent but related studies. While many meta-analyses, such…”
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Dissertation