Search Results - "Siegel, Jerome M."

Sleep function: an evolutionary perspective by Siegel, Jerome M

“…Prospective epidemiological studies in industrial societies indicate that 7 h of sleep per night in people aged 18 years or older is optimum, with higher and…”
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Natural Sleep and Its Seasonal Variations in Three Pre-industrial Societies by Yetish, Gandhi, Kaplan, Hillard, Gurven, Michael, Wood, Brian, Pontzer, Herman, Manger, Paul R., Wilson, Charles, McGregor, Ronald, Siegel, Jerome M.

“…How did humans sleep before the modern era? Because the tools to measure sleep under natural conditions were developed long after the invention of the electric…”
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Diurnal fluctuation in the number of hypocretin/orexin and histamine producing: Implication for understanding and treating neuronal loss by McGregor, Ronald, Shan, Ling, Wu, Ming-Fung, Siegel, Jerome M

“…The loss of specific neuronal phenotypes, as determined by immunohistochemistry, has become a powerful tool for identifying the nature and cause of…”
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Localized Loss of Hypocretin (Orexin) Cells in Narcolepsy Without Cataplexy by THANNICKAL, Thomas C, NIENHUIS, Robert, SIEGEL, Jerome M

“…Narcolepsy with cataplexy is characterized by a loss of approximately 90% of hypocretin (Hcrt) neurons. However, more than a quarter of narcoleptics do not…”
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Inactivity/sleep in two wild free-roaming African elephant matriarchs - Does large body size make elephants the shortest mammalian sleepers? by Gravett, Nadine, Bhagwandin, Adhil, Sutcliffe, Robert, Landen, Kelly, Chase, Michael J, Lyamin, Oleg I, Siegel, Jerome M, Manger, Paul R

“…The current study provides details of sleep (or inactivity) in two wild, free-roaming African elephant matriarchs studied in their natural habitat with remote…”
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Effects of sodium oxybate on hypocretin/orexin and locus coeruleus neurons by Wu, Ming-Fung, Thannickal, Thomas C, Li, Songlin, McGregor, Ronald, Lai, Yuan-Yang, Siegel, Jerome M

“…Abstract Long-term use of sodium oxybate (SXB), (also called gamma-hydroxybutyrate [GHB]) attenuates the cataplexy and sleepiness of human narcolepsy. We had…”
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Eye state asymmetry during aquatic unihemispheric slow wave sleep in northern fur seals (Callorhinus ursinus) by Kendall-Bar, Jessica M, Vyssotski, Alexei L, Mukhametov, Lev M, Siegel, Jerome M, Lyamin, Oleg I

“…Unihemispheric slow wave sleep (USWS) is a unique form of sleep in which one brain hemisphere maintains low voltage electrical activity indicative of waking…”
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Opiates increase the number of hypocretin-producing cells in human and mouse brain and reverse cataplexy in a mouse model of narcolepsy by Thannickal, Thomas C, John, Joshi, Shan, Ling, Swaab, Dick F, Wu, Ming-Fung, Ramanathan, Lalini, McGregor, Ronald, Chew, Keng-Tee, Cornford, Marcia, Yamanaka, Akihiro, Inutsuka, Ayumu, Fronczek, Rolf, Lammers, Gert Jan, Worley, Paul F, Siegel, Jerome M

“…The changes in brain function that perpetuate opiate addiction are unclear. In our studies of human narcolepsy, a disease caused by loss of…”
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Human hypocretin and melanin-concentrating hormone levels are linked to emotion and social interaction by Blouin, Ashley M., Fried, Itzhak, Wilson, Charles L., Staba, Richard J., Behnke, Eric J., Lam, Hoa A., Maidment, Nigel T., Karlsson, Karl Æ., Lapierre, Jennifer L., Siegel, Jerome M.

“…The neurochemical changes underlying human emotions and social behaviour are largely unknown. Here we report on the changes in the levels of two hypothalamic…”
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Systemic and Nasal Delivery of Orexin-A (Hypocretin-1) Reduces the Effects of Sleep Deprivation on Cognitive Performance in Nonhuman Primates by Deadwyler, Sam A, Porrino, Linda, Siegel, Jerome M, Hampson, Robert E

“…Hypocretin-1 (orexin-A) was administered to sleep-deprived (30-36 h) rhesus monkeys immediately preceding testing on a multi-image delayed match-to-sample…”
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Hypocretin (orexin): Role in normal behavior and neuropathology by SIEGEL, Jerome M

“…The hypocretins (Hcrts, also known as orexins) are two peptides, both synthesized by a small group of neurons, most of which are in the lateral hypothalamic…”
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Behavioral Correlates of Activity in Identified Hypocretin/Orexin Neurons by Mileykovskiy, Boris Y., Kiyashchenko, Lyudmila I., Siegel, Jerome M.

“…Micropipette recording with juxtacellular Neurobiotin ejection, linked micropipette-microwire recording, and antidromic and orthodromic activation from the…”
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Gender differences between hypocretin/orexin knockout and wild type mice: age, body weight, body composition, metabolic markers, leptin and insulin resistance by Ramanathan, Lalini, Siegel, Jerome M.

“…Female hypocretin knockout (Hcrt KO) mice have increased body weight despite decreased food intake compared to wild type (WT) mice. In order to understand the…”
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Caffeine promotes glutamate and histamine release in the posterior hypothalamus by John, Joshi, Kodama, Tohru, Siegel, Jerome M

“…Histamine neurons are active during waking and largely inactive during sleep, with minimal activity during rapid-eye movement (REM) sleep. Caffeine, the most…”
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A consensus definition of cataplexy in mouse models of narcolepsy by Scammell, Thomas E, Willie, Jon T, Guilleminault, Christian, Siegel, Jerome M

“…People with narcolepsy often have episodes of cataplexy, brief periods of muscle weakness triggered by strong emotions. Many researchers are now studying mouse…”
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Highly specific role of hypocretin (orexin) neurons: differential activation as a function of diurnal phase, operant reinforcement versus operant avoidance and light level by McGregor, Ronald, Wu, Ming-Fung, Barber, Grace, Ramanathan, Lalini, Siegel, Jerome M

“…Hypocretin (Hcrt) cell loss is responsible for narcolepsy, but Hcrt's role in normal behavior is unclear. We found that Hcrt knock-out mice were unable to work…”
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The REM Sleep-Memory Consolidation Hypothesis by Siegel, Jerome M.

“…It has been hypothesized that REM (rapid eye movement) sleep has an important role in memory consolidation. The evidence for this hypothesis is reviewed and…”
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Consensus guidelines on the construct validity of rodent models of restless legs syndrome by Salminen, Aaro V., Clemens, Stefan, García-Borreguero, Diego, Ghorayeb, Imad, Li, Yuqing, Manconi, Mauro, Ondo, William, Rye, David, Siegel, Jerome M., Silvani, Alessandro, Winkelman, John W., Allen, Richard P., Ferré, Sergi

“…Our understanding of the causes and natural course of restless legs syndrome (RLS) is incomplete. The lack of objective diagnostic biomarkers remains a…”
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Lack of hypocretin attenuates behavioral changes produced by glutamatergic activation of the perifornical-lateral hypothalamic area by Kostin, Andrey, Siegel, Jerome M, Alam, Md Noor

“…The hypocretins (HCRTs) are two hypothalamic peptides predominantly localized to neurons in the perifornical, dorsomedial, and lateral hypothalamic area…”
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The influence of age- and sex-specific labor demands on sleep in Namibian agropastoralists by Prall, Sean P., Yetish, Gandhi, Scelza, Brooke A., Siegel, Jerome M.

“…To understand the basics of sleep quality in a pastoralist population and to explore predictors of this variation. Cross-sectional. Northern Namibia, dry…”
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