Search Results - "Siegel, JM"

Clues to the functions of mammalian sleep by Siegel, Jerome M

“…The functions of mammalian sleep remain unclear. Most theories suggest a role for non-rapid eye movement (NREM) sleep in energy conservation and in nervous…”
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Opiates increase the number of hypocretin-producing cells in human and mouse brain and reverse cataplexy in a mouse model of narcolepsy by Thannickal, Thomas C, John, Joshi, Shan, Ling, Swaab, Dick F, Wu, Ming-Fung, Ramanathan, Lalini, McGregor, Ronald, Chew, Keng-Tee, Cornford, Marcia, Yamanaka, Akihiro, Inutsuka, Ayumu, Fronczek, Rolf, Lammers, Gert Jan, Worley, Paul F, Siegel, Jerome M

“…The changes in brain function that perpetuate opiate addiction are unclear. In our studies of human narcolepsy, a disease caused by loss of…”
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Hypocretin (orexin): Role in normal behavior and neuropathology by SIEGEL, Jerome M

“…The hypocretins (Hcrts, also known as orexins) are two peptides, both synthesized by a small group of neurons, most of which are in the lateral hypothalamic…”
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Behavioral Correlates of Activity in Identified Hypocretin/Orexin Neurons by Mileykovskiy, Boris Y., Kiyashchenko, Lyudmila I., Siegel, Jerome M.

“…Micropipette recording with juxtacellular Neurobiotin ejection, linked micropipette-microwire recording, and antidromic and orthodromic activation from the…”
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Rapid eye movement sleep behavior disorder: devising controlled active treatment studies for symptomatic and neuroprotective therapy—a consensus statement from the International Rapid Eye Movement Sleep Behavior Disorder Study Group by Schenck, C.H, Montplaisir, J.Y, Frauscher, B, Hogl, B, Gagnon, J.-F, Postuma, R, Sonka, K, Jennum, P, Partinen, M, Arnulf, I, Cochen de Cock, V, Dauvilliers, Y, Luppi, P.-H, Heidbreder, A, Mayer, G, Sixel-Döring, F, Trenkwalder, C, Unger, M, Young, P, Wing, Y.K, Ferini-Strambi, L, Ferri, R, Plazzi, G, Zucconi, M, Inoue, Y, Iranzo, A, Santamaria, J, Bassetti, C, Möller, J.C, Boeve, B.F, Lai, Y.Y, Pavlova, M, Saper, C, Schmidt, P, Siegel, J.M, Singer, C, St Louis, E, Videnovic, A, Oertel, W

“…Abstract Objectives We aimed to provide a consensus statement by the International Rapid Eye Movement Sleep Behavior Disorder Study Group (IRBD-SG) on devising…”
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The REM Sleep-Memory Consolidation Hypothesis by Siegel, Jerome M.

“…It has been hypothesized that REM (rapid eye movement) sleep has an important role in memory consolidation. The evidence for this hypothesis is reviewed and…”
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The neurotransmitters of sleep by Siegel, Jerome M

“…The part of the brain most important in regulating sleep duration is the hypothalamus. Certain groups of hypothalamic neurons and adjacent groups of basal…”
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Reduced Number of Hypocretin Neurons in Human Narcolepsy by Thannickal, Thomas C., Moore, Robert Y., Nienhuis, Robert, Ramanathan, Lalini, Gulyani, Seema, Aldrich, Michael, Cornford, Marsha, Siegel, Jerome M.

“…Murine and canine narcolepsy can be caused by mutations of the hypocretin (Hcrt) (orexin) precursor or Hcrt receptor genes. In contrast to these animal models,…”
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Time for the sleep community to take a critical look at the purported role of sleep in memory processing by Vertes, Robert P, Siegel, Jerome M

“…We have previously presented a wealth of data refuting the proposal that memories are processed or consolidated in sleep. Our objections have been largely…”
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The stuff dreams are made of: anatomical substrates of REM sleep by Siegel, Jerome M

“…Exactly how animals switch between different sleep states remains unknown. A new study in Nature provides a glimpse into the mechanisms and anatomy of the…”
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Cataplexy-Active Neurons in the Hypothalamus: Implications for the Role of Histamine in Sleep and Waking Behavior by John, Joshi, Wu, Ming-Fung, Boehmer, Lisa N, Siegel, Jerome M

“…Noradrenergic, serotonergic, and histaminergic neurons are continuously active during waking, reduce discharge during NREM sleep, and cease discharge during…”
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Narcolepsy: A Key Role for Hypocretins (Orexins) by Siegel, Jerome M

“…Two recent papers have linked narcolepsy to dysfunction of the newly discovered hypocretin (Hcrt) (orexin) peptide system. The paper by Lin et al. (1999…”
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Sleep deprivation decreases superoxide dismutase activity in rat hippocampus and brainstem by Ramanathan, Lalini, Gulyani, Seema, Nienhuis, Robert, Siegel, Jerome M

“…Sleep deprivation by the disk-over-water technique results in a predictable syndrome of physiological changes in rats. It has been proposed that reactive…”
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Antioxidant responses to chronic hypoxia in the rat cerebellum and pons by Ramanathan, Lalini, Gozal, David, Siegel, Jerome M.

“…Obstructive sleep apnea (OSA) is characterized by chronic intermittent hypoxia (CIH) and sleep fragmentation and deprivation. Exposure to CIH results in…”
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Release of Hypocretin (Orexin) during Waking and Sleep States by Kiyashchenko, Lyudmila I, Mileykovskiy, Boris Y, Maidment, Nigel, Lam, Hoa A, Wu, Ming-Fung, John, Joshi, Peever, John, Siegel, Jerome M

“…Hypocretin (Hcrt or orexin) somas are located in the hypothalamus and project widely to forebrain and brainstem regions, densely innervating monoaminergic and…”
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Muscle atonia is triggered by cholinergic stimulation of the basal forebrain: implication for the pathophysiology of canine narcolepsy by Nishino, S, Tafti, M, Reid, MS, Shelton, J, Siegel, JM, Dement, WC, Mignot, E

“…Narcolepsy is a sleep disorder characterized by excessive daytime sleepiness and rapid eye movement (REM) sleep-related symptoms, such as cataplexy. The exact…”
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Narp immunostaining of human hypocretin (orexin) neurons : Loss in narcolepsy by BLOUIN, A. M, THANNICKAL, T. C, WORLEY, P. F, BARABAN, J. M, RETI, I. M, SIEGEL, J. M

“…To investigate whether neuronal activity-regulated pentraxin (Narp) colocalizes with hypocretin (Hcrt or orexin) in the normal human brain and to determine if…”
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Medullary regions mediating atonia by Lai, YY, Siegel, JM

“…Electrical stimulation studies have implicated the medial medulla in the inhibition of muscle tone. In the present report we present evidence for suppression…”
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Changes in Inhibitory Amino Acid Release Linked to Pontine-Induced Atonia: An In Vivo Microdialysis Study by Kodama, Tohro, Lai, Yuan-Yang, Siegel, Jerome M

“…We hypothesized that cessation of brainstem monoaminergic systems and an activation of brainstem inhibitory systems are both involved in pontine inhibitory…”
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Weathering the Storm: The Impact of Hurricanes on Physical and Mental Health by Bourque, Linda B., Siegel, Judith M., Kano, Megumi, Wood, Michele M.

“…The authors briefly review the deaths, injuries, and diseases attributed to hurricanes that made landfall in the United States prior to Hurricane Katrina;…”
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