Search Results - "Siegel, Barry W"

A novel adenylyl cyclase-activating serotonin receptor (5-HT7) implicated in the regulation of mammalian circadian rhythms by Lovenberg, T W, Baron, B M, de Lecea, L, Miller, J D, Prosser, R A, Rea, M A, Foye, P E, Racke, M, Slone, A L, Siegel, B W

“…We report the cloning and characterization of a novel serotonin receptor, designated as 5-HT7, which is coupled to the stimulation of adenylyl cyclase. 5-HT7…”
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Binding of 5H-Dibenzo[b,e][1,4]diazepine and Chiral 5H-Dibenzo[a,d]cycloheptene Analogs of Clozapine to Dopamine and Serotonin Receptors by Phillips, Shawn T, de Paulis, Tomas, Baron, Bruce M, Siegel, Barry W, Seeman, Philip, Van Tol, Hubert H. M, Guan, Hong-chang, Smith, Howard E

“…5H-Dibenzo[b,e][1,4]diazepine, dibenz[b,f]oxepin, and 5H-dibenzo[a,d]cycloheptene analogues of clozapine [8-chloro-11-(4-methylpiperazino)-5H-…”
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Pharmacological characterization of MDL 105,519, an NMDA receptor glycine site antagonist by Baron, Bruce M, Harrison, Boyd L, Kehne, John H, Schmidt, Christopher J, Van Giersbergen, Paul L.M, White, H.Steven, Siegel, Barry W, Senyah, Yaw, McCloskey, Timothy C, Fadayel, Gina M, Taylor, Vicki L, Murawsky, Michael K, Nyce, Phillip, Salituro, Francesco G

“…MDL 105,519, ( E)-3-(2-phenyl-2-carboxyethenyl)-4,6-dichloro-1 H-indole-2-carboxylic acid, is a potent and selective inhibitor of [ 3H]glycine binding to the…”
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Binding of the radiolabeled glycine site antagonist [ 3H]MDL 105,519 to homomeric NMDA-NR1a receptors by Siegel, Barry W., Sreekrishna, Koti, Baron, Bruce M.

“…We have characterized the binding of [ 3H]MDL 105,519 (( E)-3-(2-phenyl-2-carboxyethenyl)-4,6-dichloro-1 H-indole-2-carboxylic acid), a NMDA receptor glycine…”
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Cilia Regeneration in the Sea Urchin Embryo: Evidence for a Pool of Ciliary Proteins by Auclair, Walter, Siegel, Barry W.

“…Late gastrulae of Paracentrotus lividus regenerated cilia after being deciliated in hypertonic sea water. Regeneration was not affected by actinomycin D or…”
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Binding of 5H-Dibenzo[a,d]cycloheptene and Dibenz[b,f]oxepin Analogs of Clozapine to Dopamine and Serotonin Receptors by Phillips, Shawn T, de Paulis, Tomas, Neergaard, Jon R, Baron, Bruce M, Siegel, Barry W, Seeman, Philip, Van Tol, Hubert H. M, Guan, Hong-Chang, Smith, Howard E

“…Series of 5,11-dicarbo- and 11-carbo-5-oxy-10-(1-alkyl-1,2,3,6-tetrahydro-4 pyridinyl) analogues and a 11-carbo-5-oxy-10-(1-methyl-4-piperidinyl) analogue of…”
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Preclinical characterization of the potential of the putative atypical antipsychotic MDL 100,907 as a potent 5-HT2A antagonist with a favorable CNS safety profile by Kehne, J H, Baron, B M, Carr, A A, Chaney, S F, Elands, J, Feldman, D J, Frank, R A, van Giersbergen, P L, McCloskey, T C, Johnson, M P, McCarty, D R, Poirot, M, Senyah, Y, Siegel, B W, Widmaier, C

“…In preclinical studies, [R-(+)-alpha-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4- piperidinemethanol] [formula: see text] (MDL 100,907), a putative…”
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Two Members of a Distinct Subfamily of 5-Hydroxytryptamine Receptors Differentially Expressed in Rat Brain by Erlander, Mark G., Lovenberg, Timothy W., Baron, Bruce M., de Lecea, Luis, Danielson, Patria E., Racke, Margaret, Slone, Amy L., Siegel, Barry W., Foye, Pamela E., Cannon, Keith, Burns, Jeffrey E., Sutcliffe, J. Gregor

“…We report two serotonin (5-hydroxytryptamine, 5-HT) receptors, MR22 and REC17, that belong to the G-protein-associated receptor superfamily. MR22 and REC17 are…”
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[3H]MDL 105,519, a high-affinity radioligand for the N-methyl-D-aspartate receptor-associated glycine recognition site by Baron, B M, Siegel, B W, Harrison, B L, Gross, R S, Hawes, C, Towers, P

“…MDL 105,519 [(E)-3-(2-phenyl-2-carboxyethenyl)-4, 6-dichloro-1H-indole-2-carboxylic acid] is a potent ligand at the N-methyl-D-aspartate (NMDA)…”
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Molecular Cloning and Functional Expression of 5-HT1E-Like Rat and Human 5-Hydroxytryptamine Receptor Genes by Lovenberg, Timothy W., Erlander, Mark G., Baron, Bruce M., Racke, Margaret, Slone, Amy L., Siegel, Barry W., Craft, Cheryl M., Burns, Jeffrey E., Danielson, Patria E., Sutcliffe, J. Gregor

“…Sequential polymerase chain reaction experiments were performed to amplify a unique sequence representing a guanine nucleotide-binding protein…”
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MDL 100,458 and MDL 102,288: two potent and selective glycine receptor antagonists with different functional profiles by Kehne, John H., Baron, Bruce M., Harrison, Boyd L., McCloskey, Timothy C., Palfreyman, Michael G., Poirot, Matthieu, Salituro, Francesco G., Siegel, Barry W., Slone, Amy L., Van Giersbergen, Paul L.M., White, H.Steven

“…Glycine receptor antagonists have been proposed to have multiple therapeutic applications, including the treatment of stroke, epilepsy, and anxiety. The…”
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[3H]5,7-dichlorokynurenic acid, a novel radioligand labels NMDA receptor-associated glycine binding sites by Baron, B M, Siegel, B W, Slone, A L, Harrison, B L, Palfreyman, M G, Hurt, S D

“…A strychnine-insensitive glycine binding site is located on the N-methyl-D-aspartate (NMDA)-preferring glutamate receptor complex. Kynurenic acid analogs are…”
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Rapid down regulation of beta-adrenoceptors by co-administration of desipramine and fluoxetine by Baron, B M, Ogden, A M, Siegel, B W, Stegeman, J, Ursillo, R C, Dudley, M W

“…Co-administration of desipramine and fluoxetine resulted in a 27% decline in cerebral cortical beta-adrenoceptor density after four days - a time point at…”
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Activities of novel aryloxyalkylimidazolines on rat 5-HT 2A and 5-HT 2C receptors by Siegel, Barry W., Freedman, Jules, Vaal, Mark J., Baron, Bruce M.

“…Using transfected NIH 3T3 mouse fibroblast cell lines expressing the rat 5-HT 2A and rat 5-HT 2C receptor subtypes, and techniques of 2-[ 125I](+)-iodolysergic…”
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Activities of novel aryloxyalkylimidazolines on rat 5-HT2A and 5-HT2C receptors by SIEGEL, B. W, FREEDMAN, J, VAAL, M. J, BARON, B. M

“…Using transfected NIH 3T3 mouse fibroblast cell lines expressing the rat 5-HT2A and rat 5-HT2C receptor subtypes, and techniques of 2-[125I](+)-iodolysergic…”
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