Search Results - "Siedlak, SL"

Metal Binding and Oxidation of Amyloid-β within Isolated Senile Plaque Cores:  Raman Microscopic Evidence by Dong, Jian, Atwood, Craig S, Anderson, Vernon E, Siedlak, Sandra L, Smith, Mark A, Perry, George, Carey, Paul R

“…Alzheimer's disease (AD) is characterized by the deposition of amyloid plaques in the parenchyma and vasculature of the brain. Although previous analytical…”
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Ribosomal RNA in Alzheimer Disease Is Oxidized by Bound Redox-active Iron by Honda, Kazuhiro, Smith, Mark A., Zhu, Xiongwei, Baus, Diane, Merrick, William C., Tartakoff, Alan M., Hattier, Thomas, Harris, Peggy L., Siedlak, Sandra L., Fujioka, Hisashi, Liu, Quan, Moreira, Paula I., Miller, Frank P., Nunomura, Akihiko, Shimohama, Shun, Perry, George

“…Oxidative modification of cytoplasmic RNA in vulnerable neurons is an important, well documented feature of the pathophysiology of Alzheimer disease. Here we…”
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Mitochondrial Abnormalities in Alzheimer's Disease by Hirai, Keisuke, Aliev, Gjumrakch, Nunomura, Akihiko, Fujioka, Hisashi, Russell, Robert L, Atwood, Craig S, Johnson, Anne B, Kress, Yvonne, Vinters, Harry V, Tabaton, Massimo, Shimohama, Shun, Cash, Adam D, Siedlak, Sandra L, Harris, Peggy L. R, Jones, Paul K, Petersen, Robert B, Perry, George, Smith, Mark A

“…The finding that oxidative damage, including that to nucleic acids, in Alzheimer's disease is primarily limited to the cytoplasm of susceptible neuronal…”
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Microtubule Reduction in Alzheimer's Disease and Aging Is Independent of τ Filament Formation by Cash, Adam D., Aliev, Gjumrakch, Siedlak, Sandra L., Nunomura, Akihiko, Fujioka, Hisashi, Zhu, Xiongwei, Raina, Arun K., Vinters, Harry V., Tabaton, Massimo, Johnson, Anne B., Paula-Barbosa, Manuel, Avíla, Jesus, Jones, Paul K., Castellani, Rudy J., Smith, Mark A., Perry, George

“…Biochemical studies show that phosphorylated τ, like that found in paired helical filaments (PHFs), does not promote microtubule assembly leading to the view…”
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Neurofilament proteins in neurodegenerative diseases by Liu, Q, Xie, F, Siedlak, S L, Nunomura, A, Honda, K, Moreira, P I, Zhua, X, Smith, M A, Perry, G

“…The function of neurofilaments, the major component in large myelinated neurons, is not well understood even though they were discovered as structures over 100…”
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Amyloid‐β Deposition in Alzheimer Transgenic Mice Is Associated with Oxidative Stress by Smith, Mark A., Hirai, Keisuke, Hsiao, Karen, Pappolla, Miguel A., Harris, Peggy L. R., Siedlak, Sandra L., Tabaton, Massimo, Perry, George

“…: Increased awareness for a role of oxidative stress in the pathogenesis of Alzheimer's disease has highlighted the issue of whether oxidative damage is a…”
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In Alzheimer's Disease, Heme Oxygenase Is Coincident with Alz50, an Epitope of τ Induced by 4‐Hydroxy‐2‐Nonenal Modification by Takeda, Atsushi, Smith, Mark A., Avilá, Jesus, Nunomura, Akihiko, Siedlak, Sandra L., Zhu, Xiongwei, Perry, George, Sayre, Lawrence M.

“…: In this study, we compared the neuronal induction of the antioxidant heme oxygenase‐1 (HO‐1) in Alzheimer's disease with abnormalities in τ marked by…”
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Alzheimer-specific epitopes of tau represent lipid peroxidation-induced conformations by Liu, Quan, Smith, Mark A., Avilá, Jesus, DeBernardis, John, Kansal, Mayank, Takeda, Atsushi, Zhu, Xiongwei, Nunomura, Akihiko, Honda, Kazuhiro, Moreira, Paula I., Oliveira, Catarina R., Santos, Maria S., Shimohama, Shun, Aliev, Gjumrakch, de la Torre, Jack, Ghanbari, Hossein A., Siedlak, Sandra L., Harris, Peggy L.R., Sayre, Lawrence M., Perry, George

“…Several recent studies support a link between τ protein phosphorylation and adduction of τ by reactive carbonyls. Indeed, the phosphorylation-dependent…”
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Sequestration of iron by Lewy bodies in Parkinson's disease by CASTELLANI, R. J, SIEDLAK, S. L, PERRY, G, SMITH, M. A

“…Central to the oxidative stress hypothesis of Parkinson's disease (PD) pathogenesis is the ability of iron to generate hydroxyl radicals via the Fenton…”
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Oxidative stress mechanisms and potential therapeutics in Alzheimer disease by Moreira, P I, Siedlak, S L, Aliev, G, Zhu, X, Cash, A D, Smith, M A, Perry, G

“…Oxidative damage of biological macromolecules is a hallmark of most neurodegenerative disorders such as Alzheimer, Parkinson and diffuse Lewy body diseases…”
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Hydroxynonenal adducts indicate a role for lipid peroxidation in neocortical and brainstem Lewy bodies in humans by Castellani, Rudy J, Perry, George, Siedlak, Sandra L, Nunomura, Akihiko, Shimohama, Shun, Zhang, Jing, Montine, Thomas, Sayre, Lawrence M, Smith, Mark A

“…Multiple lines of evidence indicate that oxidative stress is a critical pathogenic factor in Parkinson disease (PD) and diffuse Lewy body disease (DLBD)…”
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Activation of neuronal extracellular receptor kinase (ERK) in Alzheimer disease links oxidative stress to abnormal phosphorylation by Perry, George, Roder, Hanno, Nunomura, Akihiko, Takeda, Atsushi, Friedlich, Avi L, Zhu, Xiongwei, Raina, Arun K, Holbrook, Nikki, Siedlak, Sandra L, Harris, Peggy L. R, Smith, Mark A

“…Responses to increased oxidative stress may be the common mechanism responsible for the varied cytopathology of Alzheimer disease (AD). A possible link in…”
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Abortive apoptosis in Alzheimer's disease by RAINA, Arun K, HOCHMAN, Ayala, XIONGWEI ZHU, ROTTKAMP, Catherine A, NUNOMURA, Akihiko, SIEDLAK, Sandra L, BOUX, Heather, CASTELLANI, Rudolph J, PERRY, George, SMITH, Mark A

“…Multiple studies suggest that neuronal death in Alzheimer's disease (AD) is the result of an apoptotic mechanism. However, the stereotypical manifestations…”
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High Molecular Weight Neurofilament Proteins Are Physiological Substrates of Adduction by the Lipid Peroxidation Product Hydroxynonenal by Wataya, Takafumi, Nunomura, Akihiko, Smith, Mark A, Siedlak, Sandra L, Harris, Peggy L R, Shimohama, Shun, Szweda, Luke I, Kaminski, Matthew A, Avila, Jesus, Price, Donald L, Cleveland, Don W, Sayre, Lawrence M, Perry, George

“…Protein adducts of the lipid peroxidation product trans -4-hydroxy-2-nonenal (HNE) are features of oxidative damage in neuronal cell bodies in Alzheimer's…”
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Atherosclerotic Lesions and Mitochondria DNA Deletions in Brain Microvessels as a Central Target for the Development of Human AD and AD-Like Pathology in Aged Transgenic Mice by ALIEV, GJUMRAKCH, SEYIDOVA, DILARA, NEAL, MAXWELL L., SHI, JIONG, LAMB, BRUCE T., SIEDLAK, SANDRA L., VINTERS, HARRY V., HEAD, ELIZABETH, PERRY, GEORGE, LAMANNA, JOSEPH C., FRIEDLAND, ROBERT P., COTMAN, CARL W.

“…: We have studied the ultrastructural features of vascular lesions and mitochondria in brain vascular wall cells from human AD brain biopsy, human short…”
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Distribution, levels, and activation of MEK1 in Alzheimer's disease by Zhu, Xiongwei, Sun, Zheng, Lee, Hyoung‐gon, Siedlak, Sandra L., Perry, George, Smith, Mark A.

“…Extracellular‐signal‐regulated kinase (ERK) has been implicated in the pathogenesis of Alzheimer's disease (AD), but the upstream cascade leading to ERK…”
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Redox metals and oxidative abnormalities in human prion diseases by Petersen, Robert B, Siedlak, Sandra L, Lee, Hyoung-gon, Kim, Yong-Sun, Nunomura, Akihiko, Tagliavini, Fabrizio, Ghetti, Bernardino, Cras, Patrick, Moreira, Paula I, Castellani, Rudy J, Guentchev, Marin, Budka, Herbert, Ironside, James W, Gambetti, Pierluigi, Smith, Mark A, Perry, George

“…Prion diseases are characterized by the accumulation of diffuse and aggregated plaques of protease-resistant prion protein (PrP) in the brains of affected…”
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Adventiously-bound redox active iron and copper are at the center of oxidative damage in Alzheimer disease by Perry, George, Taddeo, Marta A, Petersen, Robert B, Castellani, Rudy J, Harris, Peggy L R, Siedlak, Sandra L, Cash, Adam D, Liu, Quan, Nunomura, Akohiko, Atwood, Craig S, Smith, Mark A

“…Central to oxidative damage in Alzheimer disease is the production of metal-catalyzed hydroxyl radicals that damage every category of macromolecule. Studies on…”
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Abnormal localization of iron regulatory protein in Alzheimer's disease by Smith, Mark A., Wehr, Kristina, Harris, Peggy L.R., Siedlak, Sandra L., Connor, James R., Perry, George

“…A role for altered iron metabolism in the pathogenesis of Alzheimer's disease has been suggested by several reports associating the cardinal neuropathologic…”
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Increased Neuronal Glucose-6-phosphate Dehydrogenase and Sulfhydryl Levels Indicate Reductive Compensation to Oxidative Stress in Alzheimer Disease by Russell, Robert L., Siedlak, Sandra L., Raina, Arun K., Bautista, José M., Smith, Mark A., Perry, George

“…We analyzed glucose-6-phosphate dehydrogenase, the rate-controlling enzyme of the pentose phosphate pathway and free sulfhydryls, to study redox balance in…”
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