Search Results - "Sieberts, S"

A clinical trial assessing the safety and efficacy of taranabant, a CB1R inverse agonist, in obese and overweight patients: a high-dose study by Aronne, L J, Tonstad, S, Moreno, M, Gantz, I, Erondu, N, Suryawanshi, S, Molony, C, Sieberts, S, Nayee, J, Meehan, A G, Shapiro, D, Heymsfield, S B, Kaufman, K D, Amatruda, J M

“…Objective: To evaluate the efficacy, safety and tolerability of taranabant in obese and overweight patients. Design: Double-blind, randomized,…”
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Integrating Genetic Association, Genetics of Gene Expression, and Single Nucleotide Polymorphism Set Analysis to Identify Susceptibility Loci for Type 2 Diabetes Mellitus by GREENAWALT, Danielle M, SIEBERTS, Solveig K, CORNELIS, Marilyn C, GIRMAN, Cynthia J, HUA ZHONG, XIA YANG, GUINNEY, Justin, LU QI, HU, Frank B

“…Large-scale genome-wide association studies (GWAS) have identified over 40 genomic regions significantly associated with type 2 diabetes mellitus. However,…”
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Relationship Inference from Trios of Individuals, in the Presence of Typing Error by Sieberts, Solveig K., Wijsman, Ellen M., Thompson, Elizabeth A.

“…Misspecification of relationships and of genotype data can cause problems in linkage analyses based on genome-scan data. Previous reports have focused on…”
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An xQTL map integrates the genetic architecture of the human brain's transcriptome and epigenome by Ng, Bernard, White, Charles C, Klein, Hans-Ulrich, Sieberts, Solveig K, McCabe, Cristin, Patrick, Ellis, Xu, Jishu, Yu, Lei, Gaiteri, Chris, Bennett, David A, Mostafavi, Sara, De Jager, Philip L

“…This paper reports the availability of a new Resource with RNA-seq, DNA methylation and H3K9Ac QTL results from 411 brain samples. Many xQTL SNPs influence…”
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Gene expression elucidates functional impact of polygenic risk for schizophrenia by Fromer, Menachem, Roussos, Panos, Sieberts, Solveig K, Johnson, Jessica S, Kavanagh, David H, Perumal, Thanneer M, Ruderfer, Douglas M, Oh, Edwin C, Topol, Aaron, Shah, Hardik R, Klei, Lambertus L, Kramer, Robin, Pinto, Dalila, Gümüş, Zeynep H, Cicek, A Ercument, Dang, Kristen K, Browne, Andrew, Lu, Cong, Xie, Lu, Readhead, Ben, Stahl, Eli A, Xiao, Jianqiu, Parvizi, Mahsa, Hamamsy, Tymor, Fullard, John F, Wang, Ying-Chih, Mahajan, Milind C, Derry, Jonathan M J, Dudley, Joel T, Hemby, Scott E, Logsdon, Benjamin A, Talbot, Konrad, Raj, Towfique, Bennett, David A, De Jager, Philip L, Zhu, Jun, Zhang, Bin, Sullivan, Patrick F, Chess, Andrew, Purcell, Shaun M, Shinobu, Leslie A, Mangravite, Lara M, Toyoshiba, Hiroyoshi, Gur, Raquel E, Hahn, Chang-Gyu, Lewis, David A, Haroutunian, Vahram, Peters, Mette A, Lipska, Barbara K, Buxbaum, Joseph D, Schadt, Eric E, Hirai, Keisuke, Roeder, Kathryn, Brennand, Kristen J, Katsanis, Nicholas, Domenici, Enrico, Devlin, Bernie, Sklar, Pamela

“…The CommonMind Consortium sequenced RNA from dorsolateral prefrontal cortex of subjects with schizophrenia ( N = 258) and control subjects ( N = 279), creating…”
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Global landscape and genetic regulation of RNA editing in cortical samples from individuals with schizophrenia by Breen, Michael S., Dobbyn, Amanda, Li, Qin, Roussos, Panos, Hoffman, Gabriel E., Stahl, Eli, Chess, Andrew, Sklar, Pamela, Li, Jin Billy, Devlin, Bernie, Buxbaum, Joseph D.

“…RNA editing critically regulates neurodevelopment and normal neuronal function. The global landscape of RNA editing was surveyed across 364 schizophrenia cases…”
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Differential activity of transcribed enhancers in the prefrontal cortex of 537 cases with schizophrenia and controls by Hauberg, Mads E., Fullard, John F., Zhu, Lingxue, Cohain, Ariella T., Giambartolomei, Claudia, Misir, Ruth, Reach, Sarah, Johnson, Jessica S., Wang, Minghui, Mattheisen, Manuel, Børglum, Anders Dupont, Zhang, Bin, Sieberts, Solveig K., Peters, Mette A., Domenici, Enrico, Schadt, Eric E., Devlin, Bernie, Sklar, Pamela, Roeder, Kathryn, Roussos, Panos

“…Transcription at enhancers is a widespread phenomenon which produces so-called enhancer RNA (eRNA) and occurs in an activity-dependent manner. However, the…”
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An integrative genomics approach to infer causal associations between gene expression and disease by Schadt, Eric E, Lamb, John, Yang, Xia, Zhu, Jun, Edwards, Steve, GuhaThakurta, Debraj, Sieberts, Solveig K, Monks, Stephanie, Reitman, Marc, Zhang, Chunsheng, Lum, Pek Yee, Leonardson, Amy, Thieringer, Rolf, Metzger, Joseph M, Yang, Liming, Castle, John, Zhu, Haoyuan, Kash, Shera F, Drake, Thomas A, Sachs, Alan, Lusis, Aldons J

“…A key goal of biomedical research is to elucidate the complex network of gene interactions underlying complex traits such as common human diseases. Here we…”
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Publisher Correction: Gene expression imputation across multiple brain regions provides insights into schizophrenia risk by Huckins, Laura M., Dobbyn, Amanda, Ruderfer, Douglas M., Hoffman, Gabriel, Wang, Weiqing, Pardiñas, Antonio F., Rajagopal, Veera M., Als, Thomas D., T. Nguyen, Hoang, Girdhar, Kiran, Boocock, James, Roussos, Panos, Fromer, Menachem, Kramer, Robin, Domenici, Enrico, Gamazon, Eric R., Purcell, Shaun, Demontis, Ditte, Børglum, Anders D., Walters, James T. R., O’Donovan, Michael C., Sullivan, Patrick, Owen, Michael J., Devlin, Bernie, Sieberts, Solveig K., Cox, Nancy J., Im, Hae Kyung, Sklar, Pamela, Stahl, Eli A.

“…In the HTML version of the article originally published, the author group ‘The Schizophrenia Working Group of the Psychiatric Genomics Consortium’ was…”
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“Bias toward the Null” Means Reduced Power by Sieberts, Solveig K., Broman, Karl W., Gudbjartsson, Daniel F.

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Approaches to mapping genetically correlated complex traits by George, Andrew W, Basu, Saonli, Li, Na, Rothstein, Joseph H, Sieberts, Solveig K, Stewart, William, Wijsman, Ellen M, Thompson, Elizabeth A

“…Our Markov chain Monte Carlo (MCMC) methods were used in linkage analyses of the Framingham Heart Study data using all available pedigrees. Our goal was to…”
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