Search Results - "Siebers, Nicholas"

Effects of ketoconazole or rifampin on the pharmacokinetics of tivozanib hydrochloride, a vascular endothelial growth factor receptor tyrosine kinase inhibitor by Cotreau, Monette M., Siebers, Nicholas M., Miller, James, Strahs, Andrew L., Slichenmyer, William

“…The vascular endothelial growth factor (VEGF) pathway is associated with the promotion of endothelial cell proliferation, migration, and survival necessary for…”
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0100 Excretion of the Dual Orexin Receptor Antagonist Daridorexant into Breast Milk of Healthy Lactating Women by Kaufmann, Priska, Anliker-Ort, Marion, Siebers, Nicholas, Muehlan, Clemens, Dingemanse, Jasper

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Transfer of the Dual Orexin Receptor Antagonist Daridorexant into Breast Milk of Healthy Lactating Women by Kaufmann, Priska, Muehlan, Clemens, Anliker‐Ort, Marion, Sabattini, Giancarlo, Siebers, Nicholas, Dingemanse, Jasper

“…The novel dual orexin receptor antagonist daridorexant was approved in 2022 for the treatment of adult patients with insomnia. The aim of this post‐marketing…”
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PHARMACOKINECTS STUDY TO EVALUATE DRUG-DRUG INTERACTIONS (DDI) BETWEEN HZN-825 AND PIRFENIDONE/NINTEDANIB by SONG, YANG, HUDSON, KRISCHAN, YE, ZHAN, CHEN, WEI, HAWLEY, LISA, ZARZOSO, JENNIFER, ROGOWSKI, JOHN, SIEBERS, NICHOLAS, VOSKUHL, GENE, SUN, YAJING, XIN, YAN

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Excretion balance and pharmacokinetics following a single oral dose of [14C]-fedratinib in healthy subjects by Ogasawara, Ken, Xu, Christine, Kanamaluru, Vanaja, Siebers, Nicholas, Surapaneni, Sekhar, Ridoux, Laurence, Palmisano, Maria, Krishna, Gopal

“…Purpose Fedratinib is an oral and selective kinase inhibitor with activity against wild type and mutationally activated Janus kinase 2 and FMS-like tyrosine…”
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Investigation of the absolute bioavailability and human mass balance of navoximod, a novel IDO1 inhibitor by Ma, Shuguang, Suchomel, Julia, Yanez, Evelyn, Yost, Edward, Liang, Xiaorong, Zhu, Rui, Le, Hoa, Siebers, Nicholas, Joas, Lori, Morley, Roland, Royer‐Joo, Stephanie, Pirzkall, Andrea, Salphati, Laurent, Ware, Joseph A., Morrissey, Kari M.

“…Aims Navoximod (GDC‐0919, NLG‐919) is a small molecule inhibitor of indoleamine‐2,3‐dioxygenase 1 (IDO1), developed to treat the acquired immune tolerance…”
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Absorption, metabolism and excretion of pictilisib, a potent pan-class I phosphatidylinositol-3-Kinase (PI3K) inhibitor, in rats, dogs, and humans by Yue, Qin, Khojasteh, S. Cyrus, Cho, Sungjoon, Ma, Shuguang, Mulder, Teresa, Chen, John, Pang, Jodie, Ding, Xiao, Deese, Alan, Pellet, Jackson D., Siebers, Nicholas, Joas, Lori, Salphati, Laurent, Ware, Joseph A.

“…The absorption, metabolism and excretion of pictilisib, a selective small molecule inhibitor of class 1 A phosphoinositide 3-kinase (PI3K), was characterized…”
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Absorption, Distribution, Metabolism, and Excretion of [14C]-Volixibat in Healthy Men: Phase 1 Open-Label Study by Siebers, Nicholas, Palmer, Melissa, Silberg, Debra G., Jennings, Lee, Bliss, Caleb, Martin, Patrick T.

“…Background and Objectives Volixibat is a potent inhibitor of the apical sodium-dependent bile acid transporter in development for the treatment of nonalcoholic…”
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Single low-dose rHuIL-12 safely triggers multilineage hematopoietic and immune-mediated effects by Gokhale, Mamata S, Vainstein, Vladimir, Tom, Jamie, Thomas, Simmy, Lawrence, Chris E, Gluzman-Poltorak, Zoya, Siebers, Nicholas, Basile, Lena A

“…Recombinant human interleukin 12 (rHuIL-12) regulates hematopoiesis and cell-mediated immunity. Based on these hematopoietic and immunomodulatory activities, a…”
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