Search Results - "Sieber, Oliver"

FunRich: An open access standalone functional enrichment and interaction network analysis tool by Pathan, Mohashin, Keerthikumar, Shivakumar, Ang, Ching-Seng, Gangoda, Lahiru, Quek, Camelia Y.J., Williamson, Nicholas A., Mouradov, Dmitri, Sieber, Oliver M., Simpson, Richard J., Salim, Agus, Bacic, Antony, Hill, Andrew F., Stroud, David A., Ryan, Michael T., Agbinya, Johnson I., Mariadason, John M., Burgess, Antony W., Mathivanan, Suresh

“…As high‐throughput techniques including proteomics become more accessible to individual laboratories, there is an urgent need for a user‐friendly…”
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Evaluation of ultraviolet photodissociation tandem mass spectrometry for the structural assignment of unsaturated fatty acid double bond positional isomers by Fang, Mengxuan, Rustam, Yepy, Palmieri, Michelle, Sieber, Oliver M., Reid, Gavin E.

“…Fatty acids are a major source of structural diversity within the lipidome due to variations in their acyl chain lengths, branching, and cyclization, as well…”
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Interleukin-11 Is the Dominant IL-6 Family Cytokine during Gastrointestinal Tumorigenesis and Can Be Targeted Therapeutically by Putoczki, Tracy L., Thiem, Stefan, Loving, Andrea, Busuttil, Rita A., Wilson, Nicholas J., Ziegler, Paul K., Nguyen, Paul M., Preaudet, Adele, Farid, Ryan, Edwards, Kirsten M., Boglev, Yeliz, Luwor, Rodney B., Jarnicki, Andrew, Horst, David, Boussioutas, Alex, Heath, Joan K., Sieber, Oliver M., Pleines, Irina, Kile, Benjamin T., Nash, Andrew, Greten, Florian R., McKenzie, Brent S., Ernst, Matthias

“…Among the cytokines linked to inflammation-associated cancer, interleukin (IL)-6 drives many of the cancer “hallmarks” through downstream activation of the…”
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BRAF V600E Mutant Colorectal Cancer Subtypes Based on Gene Expression by Barras, David, Missiaglia, Edoardo, Wirapati, Pratyaksha, Sieber, Oliver M, Jorissen, Robert N, Love, Chris, Molloy, Peter L, Jones, Ian T, McLaughlin, Stephen, Gibbs, Peter, Guinney, Justin, Simon, Iris M, Roth, Arnaud D, Bosman, Fred T, Tejpar, Sabine, Delorenzi, Mauro

“…Mutation of BRAF at the valine 600 residue occurs in approximately 10% of colorectal cancers, a group with particularly poor prognosis. The response of BRAF…”
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The anti-cancer agent APR-246 can activate several programmed cell death processes to kill malignant cells by Wang, Zilu, Hu, Huimin, Heitink, Luuk, Rogers, Kelly, You, Yue, Tan, Tao, Suen, Connie Li Wai, Garnham, Alex, Chen, Hao, Lieschke, Elizabeth, Diepstraten, Sarah T., Chang, Catherine, Chen, Tianwei, Moujalled, Diane, Sutherland, Kate, Lessene, Guillaume, Sieber, Oliver M., Visvader, Jane, Kelly, Gemma L., Strasser, Andreas

“…Mutant TP53 proteins are thought to drive the development and sustained expansion of cancers at least in part through the loss of the wild-type (wt) TP53…”
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Colorectal Cancer Cell Lines Are Representative Models of the Main Molecular Subtypes of Primary Cancer by MOURADOV, Dmitri, SLOGGETT, Clare, O'CONNOR, Liam, WILDING, Jennifer L, BICKNELL, David, TOMLINSON, Ian P. M, BODMER, Walter F, MARIADASON, John M, SIEBER, Oliver M, JORISSEN, Robert N, LOVE, Christopher G, SHAN LI, BURGESS, Antony W, ARANGO, Diego, STRAUSBERG, Robert L, BUCHANAN, Daniel, WORMALD, Samuel

“…Human colorectal cancer cell lines are used widely to investigate tumor biology, experimental therapy, and biomarkers. However, to what extent these…”
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Tolerance of whole-genome doubling propagates chromosomal instability and accelerates cancer genome evolution by Dewhurst, Sally M, McGranahan, Nicholas, Burrell, Rebecca A, Rowan, Andrew J, Grönroos, Eva, Endesfelder, David, Joshi, Tejal, Mouradov, Dmitri, Gibbs, Peter, Ward, Robyn L, Hawkins, Nicholas J, Szallasi, Zoltan, Sieber, Oliver M, Swanton, Charles

“…The contribution of whole-genome doubling to chromosomal instability (CIN) and tumor evolution is unclear. We use long-term culture of isogenic tetraploid…”
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Oncomicrobial Community Profiling Identifies Clinicomolecular and Prognostic Subtypes of Colorectal Cancer by Mouradov, Dmitri, Greenfield, Paul, Li, Shan, In, Eun-Jung, Storey, Claire, Sakthianandeswaren, Anuratha, Georgeson, Peter, Buchanan, Daniel D., Ward, Robyn L., Hawkins, Nicholas J., Skinner, Iain, Jones, Ian T., Gibbs, Peter, Ma, Chenkai, Liew, Yi Jin, Fung, Kim Y.C., Sieber, Oliver M.

“…Dysbiosis of gut microbiota is linked to the development of colorectal cancer (CRC). However, microbiota-based stratification of CRC tissue and how this…”
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Impact of BRAF mutation and microsatellite instability on the pattern of metastatic spread and prognosis in metastatic colorectal cancer by Tran, Ben, Kopetz, Scott, Tie, Jeanne, Gibbs, Peter, Jiang, Zhi‐Qin, Lieu, Christopher H., Agarwal, Atin, Maru, Dipen M., Sieber, Oliver, Desai, Jayesh

“…BACKGROUND: It is hypothesized that BRAF mutant cancers represent a discrete subset of metastatic colorectal cancer (CRC) defined by poorer survival. This…”
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Widespread FRA1-dependent control of mesenchymal transdifferentiation programs in colorectal cancer cells by Diesch, Jeannine, Sanij, Elaine, Gilan, Omer, Love, Christopher, Tran, Hoanh, Fleming, Nicholas I, Ellul, Jason, Amalia, Marcia, Haviv, Izhak, Pearson, Richard B, Tulchinsky, Eugene, Mariadason, John M, Sieber, Oliver M, Hannan, Ross D, Dhillon, Amardeep S

“…Tumor invasion and metastasis involves complex remodeling of gene expression programs governing epithelial homeostasis. Mutational activation of the RAS-ERK is…”
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Metastasis-Associated Gene Expression Changes Predict Poor Outcomes in Patients with Dukes Stage B and C Colorectal Cancer by JORISSEN, Robert N, GIBBS, Peter, ØRNTOFT, Torben F, LINDBJERG ANDERSEN, Claus, GRUIDL, Mike, KAMATH, Vidya P, ESCHRICH, Steven, YEATMAN, Timothy J, SIEBER, Oliver M, CHRISTIE, Michael, PRAKASH, Saurabh, LIPTON, Lara, DESAI, Jayesh, KERR, David, AALTONEN, Lauri A, ARANGO, Diego, KRUHØFFER, Mogens

“…Purpose: Colorectal cancer prognosis is currently predicted from pathologic staging, providing limited discrimination for Dukes stage B and C disease…”
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Low-viscosity Matrix Suspension Culture for Human Colorectal Epithelial Organoids and Tumoroids by Tan, Tao, Hirokawa, Yumiko, Clarke, Jordan, Sakthianandeswaren, Anuratha, Sieber, Oliver M

“…Three-dimensional culture of human normal colorectal epithelium and cancer tissue as organoids and tumoroids has transformed the study of diseases of the large…”
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Evaluation of PIK3CA Mutation As a Predictor of Benefit From Nonsteroidal Anti-Inflammatory Drug Therapy in Colorectal Cancer by DOMINGO, Enric, CHURCH, David N, SIEBER, Oliver, RAMAMOORTHY, Rajarajan, YANAGISAWA, Yoko, JOHNSTONE, Elaine, DAVIDSON, Brian, KERR, David J, TOMLINSON, Ian P. M, MIDGLEY, Rachel

“…Aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs) protect against colorectal cancer (CRC) and are associated with reduced disease recurrence and…”
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SMAD2, SMAD3 and SMAD4 Mutations in Colorectal Cancer by FLEMING, Nicholas I, JORISSEN, Robert N, DESAI, Jayesh, JONES, Ian T, MCLAUGHLIN, Stephen, WARD, Robyn L, HAWKINS, Nicholas J, RUSZKIEWICZ, Andrew R, MOORE, James, ZHU, Hong-Jian, MARIADASON, John M, BURGESS, Antony W, MOURADOV, Dmitri, BUSAM, Dana, QI ZHAO, STRAUSBERG, Robert L, GIBBS, Peter, SIEBER, Oliver M, CHRISTIE, Michael, SAKTHIANANDESWAREN, Anuratha, PALMIERI, Michelle, DAY, Fiona, SHAN LI, TSUI, Cary, LIPTON, Lara

“…Activation of the canonical TGF-β signaling pathway provides growth inhibitory signals in the normal intestinal epithelium. Colorectal cancers (CRCs)…”
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Dual Targeting of Bromodomain and Extraterminal Domain Proteins, and WNT or MAPK Signaling, Inhibits c-MYC Expression and Proliferation of Colorectal Cancer Cells by Tögel, Lars, Nightingale, Rebecca, Chueh, Anderly C, Jayachandran, Aparna, Tran, Hoanh, Phesse, Toby, Wu, Rui, Sieber, Oliver M, Arango, Diego, Dhillon, Amardeep S, Dawson, Mark A, Diez-Dacal, Beatriz, Gahman, Timothy C, Filippakopoulos, Panagis, Shiau, Andrew K, Mariadason, John M

“…Inhibitors of the bromodomain and extraterminal domain (BET) protein family attenuate the proliferation of several tumor cell lines. These effects are…”
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Reprogrammed Lipid Metabolism and the Lipid-Associated Hallmarks of Colorectal Cancer by Salita, Timothy, Rustam, Yepy H., Mouradov, Dmitri, Sieber, Oliver M., Reid, Gavin E.

“…Lipids have diverse structures, with multifarious regulatory functions in membrane homeostasis and bioenergetic metabolism, in mediating functional…”
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APC regulation of ESRP1 and p120-catenin isoforms in colorectal cancer cells by Faux, Maree C, King, Lauren E, Kane, Serena R, Love, Christopher, Sieber, Oliver M, Burgess, Antony W

“…The adenomatous polyposis coli (APC) tumor suppressor protein is associated with the regulation of Wnt signaling; however, APC also controls other cellular…”
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PIK3CA and PTEN gene and exon mutation-specific clinicopathologic and molecular associations in colorectal cancer by Day, Fiona L, Jorissen, Robert N, Lipton, Lara, Mouradov, Dmitri, Sakthianandeswaren, Anuratha, Christie, Michael, Li, Shan, Tsui, Cary, Tie, Jeannie, Desai, Jayesh, Xu, Zheng-Zhou, Molloy, Peter, Whitehall, Vicki, Leggett, Barbara A, Jones, Ian T, McLaughlin, Stephen, Ward, Robyn L, Hawkins, Nicholas J, Ruszkiewicz, Andrew R, Moore, James, Busam, Dana, Zhao, Qi, Strausberg, Robert L, Gibbs, Peter, Sieber, Oliver M

“…PIK3CA and PTEN mutations are prevalent in colorectal cancer and potential markers of response to mitogen-activated protein/extracellular signal-regulated…”
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Optimizing targeted therapeutic development: Analysis of a colorectal cancer patient population with the BRAFV600E mutation by Tie, Jeanne, Gibbs, Peter, Lipton, Lara, Christie, Michael, Jorissen, Robert N., Burgess, Antony W., Croxford, Matthew, Jones, Ian, Langland, Rachel, Kosmider, Suzanne, McKay, Daniel, Bollag, Gideon, Nolop, Keith, Sieber, Oliver M., Desai, Jayesh

“…BRAFV600E mutations are found in 10% of colorectal cancers (CRCs). The low frequency of this mutation therefore makes it a challenging target for drug…”
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Optimizing targeted therapeutic development: analysis of a colorectal cancer patient population with the BRAF(V600E) mutation by Tie, Jeanne, Gibbs, Peter, Lipton, Lara, Christie, Michael, Jorissen, Robert N, Burgess, Antony W, Croxford, Matthew, Jones, Ian, Langland, Rachel, Kosmider, Suzanne, McKay, Daniel, Bollag, Gideon, Nolop, Keith, Sieber, Oliver M, Desai, Jayesh

“…BRAF(V600E) mutations are found in 10% of colorectal cancers (CRCs). The low frequency of this mutation therefore makes it a challenging target for drug…”
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