Search Results - "Sidiropoulos, Dimitrios N. N."

Entinostat in combination with nivolumab in metastatic pancreatic ductal adenocarcinoma: a phase 2 clinical trial by Baretti, Marina, Danilova, Ludmila, Durham, Jennifer N., Betts, Courtney B., Cope, Leslie, Sidiropoulos, Dimitrios N., Tandurella, Joseph A., Charmsaz, Soren, Gross, Nicole, Hernandez, Alexei, Ho, Won Jin, Thoburn, Chris, Walker, Rosalind, Leatherman, James, Mitchell, Sarah, Christmas, Brian, Saeed, Ali, Gaykalova, Daria A., Yegnasubramanian, Srinivasan, Fertig, Elana J., Coussens, Lisa M., Yarchoan, Mark, Jaffee, Elizabeth, Azad, Nilofer S.

“…Pancreatic ductal adenocarcinoma (PDA) is characterized by low cytotoxic lymphocytes, abundant immune-suppressive cells, and resistance to immune checkpoint…”
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Integrated T cell cytometry metrics for immune-monitoring applications in immunotherapy clinical trials by Sidiropoulos, Dimitrios N, Stein-O'Brien, Genevieve L, Danilova, Ludmila, Gross, Nicole E, Charmsaz, Soren, Xavier, Stephanie, Leatherman, James, Wang, Hao, Yarchoan, Mark, Jaffee, Elizabeth M, Fertig, Elana J, Ho, Won Jin

“…Mass cytometry, or cytometry by TOF (CyTOF), provides a robust means of determining protein-level measurements of more than 40 markers simultaneously. While…”
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Wild primate microbiomes prevent weight gain in germ-free mice by Sidiropoulos, Dimitrios N, Al-Ghalith, Gabriel A, Shields-Cutler, Robin R, Ward, Tonya L, Johnson, Abigail J, Vangay, Pajau, Knights, Dan, Kashyap, Purna C, Xian, Yibo, Ramer-Tait, Amanda E, Clayton, Jonathan B

“…The gut microbiome harbors trillions of bacteria that play a major role in dietary nutrient extraction and host metabolism. Metabolic diseases such as obesity…”
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Immunotherapy response induces divergent tertiary lymphoid structure morphologies in hepatocellular carcinoma by Shu, Daniel H., Ho, Won Jin, Kagohara, Luciane T., Girgis, Alexander, Shin, Sarah M., Danilova, Ludmila, Lee, Jae W., Sidiropoulos, Dimitrios N., Mitchell, Sarah, Munjal, Kabeer, Howe, Kathryn, Bendinelli, Kayla J., Kartalia, Emma, Qi, Hanfei, Mo, Guanglan, Montagne, Janelle, Leatherman, James M., Lopez-Vidal, Tamara Y., Zhu, Qingfeng, Huff, Amanda L., Yuan, Xuan, Hernandez, Alexei, Coyne, Erin M., Zaidi, Neeha, Zabransky, Daniel J., Engle, Logan L., Ogurtsova, Aleksandra, Baretti, Marina, Laheru, Daniel, Durham, Jennifer N., Wang, Hao, Sunshine, Joel C., Johnston, Robert J., Deutsch, Julie Stein, Taube, Janis M., Anders, Robert A., Jaffee, Elizabeth M., Fertig, Elana J., Yarchoan, Mark

“…Tertiary lymphoid structures (TLS) are associated with improved response in solid tumors treated with immune checkpoint blockade, but understanding of the…”
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Transfer Learning Reveals Cancer-Associated Fibroblasts Are Associated with Epithelial-Mesenchymal Transition and Inflammation in Cancer Cells in Pancreatic Ductal Adenocarcinoma by Guinn, Samantha, Kinny-Köster, Benedict, Tandurella, Joseph A, Mitchell, Jacob T, Sidiropoulos, Dimitrios N, Loth, Melanie, Lyman, Melissa R, Pucsek, Alexandra B, Zabransky, Daniel J, Lee, Jae W, Kartalia, Emma, Ramani, Mili, Seppälä, Toni T, Cherry, Christopher, Suri, Reecha, Zlomke, Haley, Patel, Jignasha, He, Jin, Wolfgang, Christopher L, Yu, Jun, Zheng, Lei, Ryan, David P, Ting, David T, Kimmelman, Alec, Gupta, Anuj, Danilova, Ludmila, Elisseeff, Jennifer H, Wood, Laura D, Stein-O'Brien, Genevieve, Kagohara, Luciane T, Jaffee, Elizabeth M, Burkhart, Richard A, Fertig, Elana J, Zimmerman, Jacquelyn W

“…Pancreatic ductal adenocarcinoma (PDAC) is an aggressive malignancy characterized by an immunosuppressive tumor microenvironment enriched with…”
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Entinostat Decreases Immune Suppression to Promote Antitumor Responses in a HER2+ Breast Tumor Microenvironment by Sidiropoulos, Dimitrios N, Rafie, Christine I, Jang, Julie K, Castanon, Sofi, Baugh, Aaron G, Gonzalez, Edgar, Christmas, Brian J, Narumi, Valerie H, Davis-Marcisak, Emily F, Sharma, Gaurav, Bigelow, Emma, Vaghasia, Ajay, Gupta, Anuj, Skaist, Alyza, Considine, Michael, Wheelan, Sarah J, Ganesan, Sathish Kumar, Yu, Min, Yegnasubramanian, Srinivasan, Stearns, Vered, Connolly, Roisin M, Gaykalova, Daria A, Kagohara, Luciane T, Jaffee, Elizabeth M, Fertig, Elana J, Roussos Torres, Evanthia T

“…Therapeutic combinations to alter immunosuppressive, solid tumor microenvironments (TME), such as in breast cancer, are essential to improve responses to…”
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Systems immunology spanning tumors, lymph nodes, and periphery by Sidiropoulos, Dimitrios N, Ho, Won Jin, Jaffee, Elizabeth M, Kagohara, Luciane T, Fertig, Elana J

“…The immune system defines a complex network of tissues and cell types that orchestrate responses across the body in a dynamic manner. The local and systemic…”
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Uncovering the spatial landscape of molecular interactions within the tumor microenvironment through latent spaces by Deshpande, Atul, Loth, Melanie, Sidiropoulos, Dimitrios N, Zhang, Shuming, Yuan, Long, Bell, Alexander T F, Zhu, Qingfeng, Ho, Won Jin, Santa-Maria, Cesar, Gilkes, Daniele M, Williams, Stephen R, Uytingco, Cedric R, Chew, Jennifer, Hartnett, Andrej, Bent, Zachary W, Favorov, Alexander V, Popel, Aleksander S, Yarchoan, Mark, Kiemen, Ashley, Wu, Pei-Hsun, Fujikura, Kohei, Wirtz, Denis, Wood, Laura D, Zheng, Lei, Jaffee, Elizabeth M, Anders, Robert A, Danilova, Ludmila, Stein-O'Brien, Genevieve, Kagohara, Luciane T, Fertig, Elana J

“…Recent advances in spatial transcriptomics (STs) enable gene expression measurements from a tissue sample while retaining its spatial context. This technology…”
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PanIN and CAF transitions in pancreatic carcinogenesis revealed with spatial data integration by Bell, Alexander T F, Mitchell, Jacob T, Kiemen, Ashley L, Lyman, Melissa, Fujikura, Kohei, Lee, Jae W, Coyne, Erin, Shin, Sarah M, Nagaraj, Sushma, Deshpande, Atul, Wu, Pei-Hsun, Sidiropoulos, Dimitrios N, Erbe, Rossin, Stern, Jacob, Chan, Rena, Williams, Stephen, Chell, James M, Ciotti, Lauren, Zimmerman, Jacquelyn W, Wirtz, Denis, Ho, Won Jin, Zaidi, Neeha, Thompson, Elizabeth, Jaffee, Elizabeth M, Wood, Laura D, Fertig, Elana J, Kagohara, Luciane T

“…This study introduces a new imaging, spatial transcriptomics (ST), and single-cell RNA-sequencing integration pipeline to characterize neoplastic cell state…”
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Phosphodiesterase-5 inhibition collaborates with vaccine-based immunotherapy to reprogram myeloid cells in pancreatic ductal adenocarcinoma by Gross, Nicole E, Zhang, Zhehao, Mitchell, Jacob T, Charmsaz, Soren, Hernandez, Alexei G, Coyne, Erin M, Shin, Sarah M, Vargas Carvajal, Diana Carolina, Sidiropoulos, Dimitrios N, Cho, Yeonju, Mo, Guanglan, Yuan, Xuan, Cannon, Courtney, Suresh Babu, Jayalaxmi, Lyman, Melissa R, Armstrong, Todd, Kagohara, Luciane T, Bever, Katherine M, Le, Dung T, Jaffee, Elizabeth M, Fertig, Elana J, Ho, Won Jin

“…Pancreatic ductal adenocarcinoma (PDAC) is highly lethal and resistant to immunotherapy. Although immune recognition can be enhanced with immunomodulatory…”
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Spatially resolved immune receptor repertoires from Visium transcriptomic libraries by Montagne, Janelle Marie, Sidiropoulos, Dimitrios N., Mo, Guanglan, Zhu, Qingfeng, Anders, Robert A., Zheng, Lei, Jaffee, Elizabeth M., Larman, H. Benjamin, Fertig, Elana J., Kagohara, Luciane T.

“…Recent advances have enabled the integration of T cell receptor (TCR) sequencing into spatial transcriptomics. Current approaches yield critical information…”
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Abstract PO-111: A human single-cell RNA sequencing atlas of pancreatic ductal adenocarcinoma enables harmonized cell type calling and comprehensive analyses of potential intercellular signaling by Kinny-Köster, Benedict, Lyman, Melissa R., Sidiropoulos, Dimitrios N., Loth, Melanie, Puscek, Alexandra B., Wood, Laura D., He, Jin, Yu, Jun, Burkhart, Richard A., Jaffee, Elizabeth M., Zimmerman, Jacquelyn W., Fertig, Elana J.

“…Purpose: Pancreatic ductal adenocarcinoma (PDAC) is characterized by a dismal prognosis, low ductal cancer cellularity and a dominant tumor microenvironment…”
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Characterization of the immune tumor microenvironment of HER2-positive breast cancer following treatment with entinostat and immune checkpoint inhibition by Roussos Torres, Evanthia T., Sidiropoulos, Dimitrios N, Davis-Marcisak, Emily, Kagohara, Luciane Tsukamoto, Connolly, Roisin M., Stearns, Vered, Jaffee, Elizabeth M., Fertig, Elana J.

“…Abstract only e15061 Background: HER2+ breast cancers are known to be less-immunogenic and associated with low response rates to immune checkpoint inhibitors…”
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Abstract 1555: Single cell level treatment-specific characterization of HER2+ breast cancers treated with immune checkpoint inhibitors and entinostat by Sidiropoulos, Dimitrios N., Davis-Marcisak, Emily, Rafie, Christine, Kagohara, Luciane T., Sharma, Gaurav, Connolly, Roisin M., Stearns, Vered, Yegnasubramanian, Srinivasan, Jaffee, Elizabeth M., Fertig, Elana J., Torres, Evanthia T. Roussos

“…HER2+ breast cancers are known to be less-immunogenic and associated with low response rates to ICIs such as anti-PD-1, anti-PDL-1 or anti-CTLA-4. A…”
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Abstract A028: Disparities in suppressive immunity in Hispanic/Latina patients with hormone receptor positive breast cancer by Carrel, Sabrina, Li, Michelle, Al-Zubeidy, Batul, Zavala, Dominic, Gonzales, Edgar, Baugh, Aaron, Castanon, Sofi, Hsu, Robert, Sidiropoulos, Dimitrios N, Ma, Yanling, Press, Michael, Torres, Evanthia T Roussos

“…In the US, breast cancer is the number one cancer diagnosed, and it is responsible for the most cancer related deaths among Hispanic/Latina (H/L) women. The…”
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Abstract 1970: Single cell proteomic quantification of T cell states using mass cytometry for applications in monitoring immune responses in cancer immunotherapy clinical trials by Sidiropoulos, Dimitrios N., Phyo, Zaw, Gross, Nicole, Charmsaz, Soren, Xavier, Stephanie, Leatherman, James, Yarchoan, Mark, Jaffee, Elizabeth M., Fertig, Elana J., Ho, Won Jin

“…Although immunotherapies have been established as a successful treatment option for several types of cancers, additional treatment strategies are necessary to…”
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Abstract CT016: Immunomodulation of the tumor microenvironment of pancreatic ductal adenocarcinoma with histone deacetylase inhibition: Results of a phase 2 clinical trial of entinostat in combination with nivolumab by Baretti, Marina, Danilova, Ludmila, Durham, Jennifer N., Betts, Courtney B., Cope, Leslie, Sidiropoulos, Dimitrios N., Tandurella, Joseph A., Charmsaz, Soren, Gross, Nicole, Hernandez, Alexei, HO, Won J., Thoburn, Chris, Walker, Rosalind, Leatherman, James Leatherman, Mitchell, Sarah, Christmas, Brian, Gaykalova, Daria A., Yegnasubramanian, Srinivasan, Fertig, Elana J., Coussens, Lisa M., Yarchoan, Mark, Jaffee, Elizabeth, Azad, Nilofer S.

“…Background The tumor microenvironment (TME) of pancreatic ductal adenocarcinoma (PDA) is characterized by a paucity of cytotoxic tumor-infiltrating…”
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Abstract 1159: Machine learning integrating spatial omics uncovers humoral immunity patterns in intratumoral tertiary lymphoid structures in pancreatic cancer pathologic responders by Sidiropoulos, Dimitrios N., Shin, Sarah M., Girgis, Alexander, Shu, Daniel H., Montagne, Janelle, Deshpande, Atul, Johnson, Jeanette A., Dequiedt, Lucie, Jacobs, Victoria, Ogurtsova, Aleksandra, Mo, Guanglan, Yuan, Xuan, Stein-O’Brien, Genevieve, Yarchoan, Mark, Zhu, Qingfeng, Kiemen, Ashley, Jaffee, Elizabeth M., Zheng, Lei, Ho, Won Jin, Anders, Robert, Fertig, Elana J., Kagohara, Luciane T.

“…Background: In pancreatic ductal adenocarcinoma (PDAC), rare long-term survivors correlate with high intratumoral tertiary lymphoid structure (TLS) density…”
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Abstract 2661: Identification of a novel morphology of tertiary lymphoid structure in patients with hepatocellular carcinoma treated with neoadjuvant immune checkpoint blockade by Shu, Daniel H., Ho, Won Jin, Kagohara, Luciane T., Girgis, Alexander, Shin, Sarah M., Danilova, Ludmila, Lee, Jae W., Sidiropoulos, Dimitrios N. N., Mitchell, Sarah, Munjal, Kabeer, Howe, Kathryn, Bendinelli, Kayla J., Qi, Hanfei, Mo, Guanglan, Montagne, Janelle, Lopez-Vidal, Tamara Y., Zhu, Qingfeng, Huff, Amanda L., Yuan, Xuan, Hernandez, Alexei, Coyne, Erin M., Zaidi, Neeha, Zabransky, Daniel J., Engle, Logan L., Ogurtsova, Aleksandra, Baretti, Marina, Laheru, Daniel, Durham, Jennifer N., Wang, Hao, Anders, Robert, Jaffee, Elizabeth M., Fertig, Elana J., Yarchoan, Mark

“…Background: Tertiary lymphoid structures (TLS) are ectopic lymphoid follicles that arise in non-lymphoid tissue. TLS may contribute to response to immune…”
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Abstract 3241: Single-cell RNA and TCR sequencing of tumor infiltrating lymphocytes identifies changes in pancreatic ductal adenocarcinomas following neoadjuvant treatment with combined anti-PD-1 blocking and anti-CD137 agonist therapy by Tandurella, Joseph A., Mitchell, Jacob T., Montagne, Janelle M., Christenson, Eric, Zhu, Qingfeng, Danilova, Ludmilla V., Favorov, Alexander V., Ho, Won J., Kagohara, Luciane T., Loth, Melanie, Lim, Su Jin, Zheng, Rui, Gai, Jessica, Mitchell, Sarah, Sidiropoulos, Dimitrios N., Hou, Wenpin, Xu, Yao, Wang, Hao, Zimmerman, Jacquelyn W., Yegnasubramanian, Srinivasan, Anders, Robert, Jaffee, Elizabeth M., Zheng, Lei, Fertig, Elana J.

“…Introduction: Pancreatic ductal adenocarcinomas (PDACs) are immunogenically “cold” tumors that lack effector T cell infiltration associated with immune…”
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