Search Results - "Siders, William M"

Investigation of the mechanism of action of alemtuzumab in a human CD52 transgenic mouse model by Hu, Yanping, Turner, Michael J, Shields, Jacqueline, Gale, Matthew S, Hutto, Elizabeth, Roberts, Bruce L, Siders, William M, Kaplan, Johanne M

“…Alemtuzumab is a humanized monoclonal antibody against CD52, an antigen found on the surface of normal and malignant lymphocytes. It is approved for the…”
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Reduction of inflammation and preservation of neurological function by anti-CD52 therapy in murine experimental autoimmune encephalomyelitis by Turner, Michael J, Pang, Petti T, Chretien, Nathalie, Havari, Evis, LaMorte, Michael J, Oliver, Julian, Pande, Nilesh, Masterjohn, Elizabeth, Carter, Karen, Reczek, David, Brondyk, William, Roberts, Bruce L, Kaplan, Johanne M, Siders, William M

“…Abstract Alemtuzumab, a monoclonal antibody directed against human CD52, is used in the treatment of MS. To characterize the impact of anti-CD52…”
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Immune status following alemtuzumab treatment in human CD52 transgenic mice by Turner, Michael J, LaMorte, Michael J, Chretien, Nathalie, Havari, Evis, Roberts, Bruce L, Kaplan, Johanne M, Siders, William M

“…Abstract Alemtuzumab is a monoclonal antibody against the CD52 antigen present at high levels on the surface of lymphocytes. While treatment of multiple…”
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Involvement of neutrophils and natural killer cells in the anti-tumor activity of alemtuzumab in xenograft tumor models by Siders, William M., Shields, Jacqueline, Garron, Carrie, Hu, Yanping, Boutin, Paula, Shankara, Srinivas, Weber, William, Roberts, Bruce, Kaplan, Johanne M.

“…Alemtuzumab is a recombinant humanized IgG1 monoclonal antibody directed against CD52, an antigen expressed on the surface of normal and malignant B and T…”
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Induction of Antitumor Immunity by Semi-Allogeneic and Fully Allogeneic Electrofusion Products of Tumor Cells and Dendritic Cells by Siders, William M., Garron, Carrie, Shields, Jacqueline, Kaplan, Johanne M.

“…Immunization with the electrofusion product of tumor cells and dendritic cells (DCs) is a promising approach to cancer immunotherapy. Production of…”
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Treatment with anti-mouse CD52 antibody is associated with preservation of myelin and maintenance of axonal conduction in the MOG-induced EAE mouse model by Kaplan, Johanne M, Huang, Jianhua, Pang, Petti, Pande, Nilesh, Turner, Michael J, Lamorte, Michael J, Chretien, Nathalie, Garron, Carrie, Roberts, Bruce L, Siders, William M

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Anti-murine CD52 antibody treatment does not adversely affect the migratory ability of immune cells by Havari, Evis, Turner, Michael J, Dodge, James C, Treleaven, Christopher, Shihabuddin, Lamya S, Roberts, Bruce L, Kaplan, Johanne M, Siders, William M

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Induction of specific antitumor immunity in the mouse with the electrofusion product of tumor cells and dendritic cells by Siders, William M, Vergilis, Kristin L, Johnson, Carrie, Shields, Jacqueline, Kaplan, Johanne M

“…Dendritic cells (DCs) are potent antigen-presenting cells capable of inducing primary T-cell responses. Several immunotherapy treatment strategies involve…”
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Cytotoxic T lymphocyte responses to transgene product, not adeno-associated viral capsid protein, limit transgene expression in mice by Siders, William M, Shields, Jacqueline, Kaplan, Johanne, Lukason, Michael, Woodworth, Lisa, Wadsworth, Sam, Scaria, Abraham

“…The use of adeno-associated viral (AAV) vectors for gene replacement therapy is currently being explored in several clinical indications. However, reports have…”
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80. Pre-Existing Cytotoxic T-Lymphocyte (CTL) Responses to the AAV CAP Protein Do Not Interfere with AAV Transgene Expression in Mice by Siders, William M., Kaplan, Johanne, Lukason, Michael, Shields, Jacqueline, Woodworth, Lisa, Wadsworth, Sam, Scaria, Abraham

“…The use of adeno-associated viral (AAV) vectors as a delivery method for gene replacement strategies is currently being explored in several clinical…”
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Cationic lipid:bacterial DNA complexes elicit adaptive cellular immunity in murine intraperitoneal tumor models by LANUTI, M, RUDGINSKY, S, FORCE, S. D, LAMBRIGHT, E. S, SIDERS, W. M, CHANG, M. Y, AMIN, K. M, KAISER, L. R, SCHEULE, R. K, ALBELDA, S. M

“…Previous studies with a mycobacterial heat shock protein (hsp-65) have demonstrated some efficacy using cationic liposome-mediated gene transfer in murine i.p…”
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Tumor Treatment with Complexes of Cationic Lipid and Noncoding Plasmid DNA Results in the Induction of Cytotoxic T Cells and Systemic Tumor Elimination by Siders, William M., Vergillis, Kristin, Johnson, Carrie, Scheule, Ronald K., Kaplan, Johanne M.

“…We have demonstrated recently that treatment of established peritoneal mesothelial tumors with complexes composed of cationic lipid and noncoding plasmid DNA…”
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T Cell- and NK Cell-Independent Inhibition of Hepatic Metastases by Systemic Administration of an IL-12-Expressing Recombinant Adenovirus by Siders, William M, Wright, Paul W, Hixon, Julie A, Alvord, W. Gregory, Back, Timothy C, Wiltrout, Robert H, Fenton, Robert G

“…IL-12 is a potent immunoregulatory cytokine that has been shown to mediate tumor regression in a variety of tumor models. We describe the construction of…”
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Transcriptional targeting of recombinant adenoviruses to human and murine melanoma cells by SIDERS, W. M, HALLORAN, P. J, FENTON, R. G

“…One potential avenue for future cancer therapy involves the specific targeting of effector genes to cancer cells throughout the body, including distant…”
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Abstract 2445: Involvement of neutrophils and natural killer cells in the anti-tumor activity of alemtuzumab in xenograft tumor models by Siders, William M., Shields, Jacqueline, Garron, Carrie, Hu, Yanping, Boutin, Paula, Shankara, Srinivas, Weber, William, Roberts, Bruce, Kaplan, Johanne M.

“…Alemtuzumab (Campath) is a recombinant humanized IgG1 monoclonal antibody directed against CD52, an antigen expressed at high levels on the surface of normal…”
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Interleukin-1β Secretion. A POSSIBLE MULTISTEP PROCESS THAT IS REGULATED IN A CELL TYPE-SPECIFIC MANNER by Siders, William M., Mizel, Steven B.

“…In a prior study, we found that the processed form of human interleukin-1β (mature IL-1β) is secreted to a significantly greater extent than the precursor form…”
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Melanoma-specific cytotoxicity induced by a tyrosinase promoter-enhancer/herpes simplex virus thymidine kinase adenovirus by Siders, W M, Halloran, P J, Fenton, R G

“…The ability to specifically and efficiently express selected genes in tumor cells is an important goal for cancer gene therapy. Transcriptional targeting of…”
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Interleukin-1 Secretion. A POSSIBLE MULTISTEP PROCESS THAT IS REGULATED IN A CELL TYPE-SPECIFIC MANNER by William M. Siders, Steven B. Mizel

“…In a prior study, we found that the processed form of human interleukin-1β (mature IL-1β) is secreted to a significantly greater extent than the precursor…”
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Characterization of the structural requirements and cell type specificity of IL-1 alpha and IL-1 beta secretion by SIDERS, W. M, KLIMOVITZ, J. C, MIZEL, S. B

“…The murine macrophage cell line, P388D1, was transfected with expression plasmids containing a cDNA for the precursor or mature form of human interleukin…”
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