Coronary-Artery Calcification in Young Adults with End-Stage Renal Disease Who Are Undergoing Dialysis

Coronary-Artery Calcification in Young Adults with End-Stage Renal Disease Who Are Undergoing Dialysis

The life span of adults with end-stage renal disease is reduced, and cardiovascular disease accounts for approximately half the deaths among adults undergoing regular dialysis. 1 , 2 Contributing factors include hypertension, glucose intolerance, dyslipidemia, high serum homocysteine concentrations,...

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Bibliographic Details
Published in:The New England journal of medicine Vol. 342; no. 20; pp. 1478 - 1483
Main Authors: Goodman, William G, Goldin, Jonathan, Kuizon, Beatriz D, Yoon, Chun, Gales, Barbara, Sider, Donna, Wang, Yan, Chung, Joanie, Emerick, Aletha, Greaser, Lloyd, Elashoff, Robert M, Salusky, Isidro B
Format: Journal Article
Language:English
Published: United States Massachusetts Medical Society 18-05-2000
Subjects:
Adolescent
Adult
Age Factors
Calcinosis - blood
Calcinosis - diagnostic imaging
Calcinosis - etiology
Calcium - administration & dosage
Calcium - blood
Child
coronary artery
Coronary Disease - blood
Coronary Disease - diagnostic imaging
Coronary Disease - etiology
Coronary vessels
Disease
Female
Hemodialysis
Humans
Kidney Failure, Chronic - blood
Kidney Failure, Chronic - complications
Kidney Failure, Chronic - therapy
Kidneys
Male
Medical research
Phosphorus - blood
Renal Dialysis
Time Factors
Tomography, X-Ray Computed - methods
Young adults
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Summary:The life span of adults with end-stage renal disease is reduced, and cardiovascular disease accounts for approximately half the deaths among adults undergoing regular dialysis. 1 , 2 Contributing factors include hypertension, glucose intolerance, dyslipidemia, high serum homocysteine concentrations, and abnormalities in calcium and phosphorus metabolism. 3 – 9 Many of the same disturbances are present in children and young adults with end-stage renal disease, but little is known about the prevalence or extent of cardiovascular disease in these patients. The presence and progression of calcified coronary-artery lesions can be determined by electron-beam computed tomography (CT). 10 – 13 The prevalence of coronary-artery calcification increases with . . .
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ISSN:0028-4793
1533-4406
DOI:10.1056/NEJM200005183422003