Search Results - "Sidell, K. R."

The Lipid Peroxidation Product 4‐Hydroxynonenal Inhibits Neurite Outgrowth, Disrupts Neuronal Microtubules, and Modifies Cellular Tubulin by Neely, M. D., Sidell, K. R., Graham, D. G., Montine, T. J.

“…: Oxidative stress is believed to be an important factor in the development of age‐related neurodegenerative diseases such as Alzheimer's disease (AD). The CNS…”
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Elevated CSF prostaglandin E2 levels in patients with probable AD by MONTINE, T. J, SIDELL, K. R, CREWS, B. C, MARKESBERY, W. R, MARNETT, L. J, ROBERTS, L. J, MORROW, J. D

“…To determine CSF eicosanoid concentrations and brain cyclo-oxygenase activity in AD patients and age-matched control subjects. Nonsteroidal anti-inflammatory…”
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Distribution of Reducible 4-Hydroxynonenal Adduct Immunoreactivity in Alzheimer Disease is Associated with APOE Genotype by Montine, Kathleen S, Reich, Erin, Neely, M Diana, Sidell, Kathrin R, Olson, Sandra J, Markesbery, William R, Montine, Thomas J

“…Two major risk factors for late-onset familial and sporadic Alzheimer disease (AD), a leading cause of dementia worldwide, are increasing age and inheritance…”
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Divergence of Brain Prostaglandin H Synthase Activity and Oxidative Damage in Mice with Encephalitis by Valyi-Nagy, Tibor, Sidell, Kathrin R, Marnett, Lawrence J, Roberts, L Jackson, Dermody, Terence S, Morrow, Jason D, Montine, Thomas J

“…Several lines of evidence point to inflammation and increased oxidant injury in brain regions of patients with Alzheimer disease (AD). Prostaglandin H synthase…”
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Dopamine thioethers in neurodegeneration by Sidell, K R, Amamath, V, Montine, T J

“…Dopamine oxidation is proposed to be a significant contributor to mesostriatal dopaminergic neurodegeneration, although the mechanisms are not fully resolved…”
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Cerebrospinal fluid lipoproteins are more vulnerable to oxidation in Alzheimer's disease and are neurotoxic when oxidized ex vivo by Bassett, Casey N., Neely, M. Diana, Sidell, Kathrin R., Markesbery, William R., Switt, Larry L., Montine, Thomas J.

“…Brain regional oxidative damage is thought to be a central mechanism in the pathogenesis of Alzheimer's disease (AD). Recent studies of cerebrospinal fluid…”
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Cysteine and mercapturate conjugates of oxidized dopamine are in human striatum but only the cysteine conjugate impedes dopamine trafficking in vitro and in vivo by Sidell, Kathrin R., Olson, Sandra J., Ou, Joyce J., Zhang, Yueli, Amarnath, Ventkataraman, Montine, Thomas J.

“…Recent results have suggested that some products of mercapturic acid pathway (MAP) metabolism of oxidized dopamine (DA) may contribute to mesostriatal…”
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DOPAMINE MERCAPTURATE CAN AUGMENT DOPAMINERGIC NEURODEGENERATION by MONTINE, THOMAS J., AMARNATH, VENTKATARAMAN, PICKLO, MATTHEW J., SIDELL, KATHRIN R., ZHANG, JING, GRAHAM, DOYLE G.

“…Pathological and biochemical studies have consistently associated endogenous catechol oxidation with dopaminergic neurodegeneration in Parkinson's disease…”
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Elevated CSF prostaglandin E 2 levels in patients with probable AD by Montine, T.J., Sidell, K.R., Crews, B.C., Markesbery, W.R., Marnett, L.J., Roberts, L.J., Morrow, J.D.

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Mercapturate Metabolism of 4-Hydroxy-2-Nonenal ien Rat and Human Cerebrum by SIDELL, KATHRIN R, MONTINE, KATHLEEN S, PICKLO, MATTHEW J, OLSEN, SANDRA J, AMARNATH, VENTKATARAMAN, MONTINE, THOMAS J

“…4-Hydroxy-2-nonenal (HNE), a potent toxin formed in the brain from oxidation of polyunsaturated fatty acids, is increased in Alzheimer disease (AD), where it…”
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Mercapturate metabolism of 4-hydroxy-2-nonenal in rat and human cerebrum by SIDELL, Kathrin R, MONTINE, Kathleen S, PICKLO, Matthew J, OLSEN, Sandra J, AMARNATH, Ventkataraman, MONTINE, Thomas J

“…4-Hydroxy-2-nonenal (HNE), a potent toxin formed in the brain from oxidation of polyunsaturated fatty acids, is increased in Alzheimer disease (AD), where it…”
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