Search Results - "Siddle, Kenneth"

Signalling by insulin and IGF receptors: supporting acts and new players by Siddle, Kenneth

“…The signalling pathways utilised by insulin receptor (IR) and IGF receptor to transduce their diverse effects on cellular metabolism, growth and survival are…”
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Molecular basis of signaling specificity of insulin and IGF receptors: neglected corners and recent advances by Siddle, Kenneth

“…Insulin and insulin-like growth factor (IGF) receptors utilize common phosphoinositide 3-kinase/Akt and Ras/extracellular signal-regulated kinase signaling…”
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Characterization of insulin/IGF hybrid receptors: contributions of the insulin receptor L2 and Fn1 domains and the alternatively spliced exon 11 sequence to ligand binding and receptor activation by Benyoucef, Samira, Surinya, Katharina H, Hadaschik, Dirk, Siddle, Kenneth

“…The IR (insulin receptor) and IGFR (type I insulin-like growth factor receptor) are found as homodimers, but the respective pro-receptors can also…”
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Overexpression of Igf2-derived Mir483 inhibits Igf1 expression and leads to developmental growth restriction and metabolic dysfunction in mice by Sandovici, Ionel, Fernandez-Twinn, Denise S., Campbell, Niamh, Cooper, Wendy N., Sekita, Yoichi, Zvetkova, Ilona, Ferland-McCollough, David, Prosser, Haydn M., Oyama, Lila M., Pantaleão, Lucas C., Cimadomo, Danilo, Barbosa de Queiroz, Karina, Cheuk, Cecilia S.K., Smith, Nicola M., Kay, Richard G., Antrobus, Robin, Hoelle, Katharina, Ma, Marcella K.L., Smith, Noel H., Geyer, Stefan H., Reissig, Lukas F., Weninger, Wolfgang J., Siddle, Kenneth, Willis, Anne E., Lam, Brian Y.H., Bushell, Martin, Ozanne, Susan E., Constância, Miguel

“…Mir483 is a conserved and highly expressed microRNA in placental mammals, embedded within the Igf2 gene. Its expression is dysregulated in a number of human…”
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Grb10 and Grb14: enigmatic regulators of insulin action--and more? by Holt, Lowenna J, Siddle, Kenneth

“…The Grb proteins (growth factor receptor-bound proteins) Grb7, Grb10 and Grb14 constitute a family of structurally related multidomain adapters with diverse…”
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Two isoforms of the mRNA binding protein IGF2BP2 are generated by alternative translational initiation by Le, Hang T T, Sorrell, Alice M, Siddle, Kenneth

“…IGF2BP2 is a member of a family of mRNA binding proteins that, collectively, have been shown to bind to several different mRNAs in mammalian cells, including…”
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An Investigation of the Ligand Binding Properties and Negative Cooperativity of Soluble Insulin-like Growth Factor Receptors by Surinya, Katharina Helen, Forbes, Briony E., Occhiodoro, Filomena, Booker, Grant W., Francis, Geoffrey Leonard, Siddle, Kenneth, Wallace, John C., Cosgrove, Leah J.

“…To investigate the interaction of the insulin-like growth factor (IGF) ligands with the insulin-like growth factor type 1 receptor (IGF-1R), we have generated…”
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Insulin and Insulin-like Growth Factor-I (IGF-I) Receptor Overexpression in Breast Cancers Leads to Insulin/IGF-I Hybrid Receptor Overexpression: Evidence for a Second Mechanism of IGF-I Signaling by PANDINI, G, VIGNERI, R, COSTANTINO, A, FRASCA, F, IPPOLITO, A, FUJITA-YAMAGUCHI, Y, SIDDLE, K, GOLDFINE, I. D, BELFIORE, A

“…The insulin receptor (IR) form hybrids with the closely related insulin-like growth factor-I (IGF-I) receptor (IGF-I-R). Because most human breast carcinomas…”
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Regulation of Insulin Receptor Substrate 1 Pleckstrin Homology Domain by Protein Kinase C: Role of Serine 24 Phosphorylation by Nawaratne, Ranmali, Gray, Alexander, Jørgensen, Christina H, Downes, C. Peter, Siddle, Kenneth, Sethi, Jaswinder K

“…Phosphorylation of insulin receptor substrate (IRS) proteins on serine residues is an important posttranslational modification that is linked to insulin…”
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Insulin receptor/IGF-I receptor hybrids are widely distributed in mammalian tissues: quantification of individual receptor species by selective immunoprecipitation and immunoblotting by Bailyes, E M, Navé, B T, Soos, M A, Orr, S R, Hayward, A C, Siddle, K

“…The insulin receptor (IR) and type 1 insulin-like growth factor (IGF-I) receptor (IGFR) are both widely expressed in mammalian tissues, and are known to be…”
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Microarray Analysis of Insulin and Insulin-like Growth Factor-1 (IGF-1) Receptor Signaling Reveals the Selective Up-regulation of the Mitogen Heparin-binding EGF-like Growth Factor by IGF-1 by Mulligan, Claire, Rochford, Justin, Denyer, Gareth, Stephens, Richard, Yeo, Giles, Freeman, Thomas, Siddle, Kenneth, O'Rahilly, Stephen

“…Insulin and insulin-like growth factor-1 (IGF-1) act through highly homologous receptors that engage similar intracellular signaling pathways, yet these…”
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Human preadipocytes display a depot-specific susceptibility to apoptosis by NIESLER, C. U, SIDDLE, K, PRINS, J. B

“…Adipose tissue mass is determined by both the number and volume of adipose cells. Adipose cell number reflects the balance of cell acquisition and cell loss,…”
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Role of Insulin Receptor Dimerization Domains in Ligand Binding, Cooperativity, and Modulation by Anti-receptor Antibodies by Surinya, Katharina Helen, Molina, Laurence, Soos, Maria A., Brandt, Jakob, Kristensen, Claus, Siddle, Kenneth

“…To define the structures within the insulin receptor (IR) that are required for high affinity ligand binding, we have used IR fragments consisting of four…”
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Correction to: Cell-autonomous programming ofrat adipose tissue insulin signalling proteins by maternal nutrition by Martin-Gronert, Malgorzata S, Fernandez-Twinn, Denise S, Bushell, Martin, Siddle, Kenneth, Ozanne, Susan E

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Differences in Signaling Properties of the Cytoplasmic Domains of the Insulin Receptor and Insulin-like Growth Factor Receptor in 3T3-L1 Adipocytes by Ursø, Birgitte, Cope, Diane L., Kalloo-Hosein, Heidi E., Hayward, Amanda C., Whitehead, Jon P., O'Rahilly, Stephen, Siddle, Kenneth

“…Insulin and insulin-like growth factors (IGFs) elicit distinct but overlapping biological effects in vivo. To investigate whether differences in intrinsic…”
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Correction to: Cell-autonomous programming of rat adipose tissue insulin signalling proteins by maternal nutrition by Martin-Gronert, Malgorzata S., Fernandez-Twinn, Denise S., Bushell, Martin, Siddle, Kenneth, Ozanne, Susan E.

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Anti-Insulin Receptor Antibodies Improve Hyperglycemia in a Mouse Model of Human Insulin Receptoropathy by Brierley, Gemma V, Webber, Hannah, Rasijeff, Eerika, Grocott, Sarah, Siddle, Kenneth, Semple, Robert K

“…Loss-of-function mutations in both alleles of the human insulin receptor gene (INSR) cause extreme insulin resistance (IR) and usually death in childhood, with…”
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Chloroquine Extends the Lifetime of the Activated Insulin Receptor Complex in Endosomes by Bevan, A. Paul, Krook, Anna, Tikerpae, Jaak, Seabright, Paul J., Siddle, Kenneth, Smith, Geoffrey D.

“…Insulin signal transduction, initiated by binding of insulin to its receptor at the plasma membrane, activates the intrinsic receptor tyrosine kinase and leads…”
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Correction to ‘The human insulin receptor mRNA contains a functional internal ribosome entry segment’ by Spriggs, Keith A, Cobbold, Laura C, Ridley, Simon H, Coldwell, Mark, Bottley, Andrew, Bushell, Martin, Willis, Anne E, Siddle, Kenneth

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Evaluation of anti-insulin receptor antibodies as potential novel therapies for human insulin receptoropathy using cell culture models by Brierley, Gemma V., Siddle, Kenneth, Semple, Robert K.

“…Aims/hypothesis Bi-allelic loss-of-function mutations in the INSR gene (encoding the insulin receptor [INSR]) commonly cause extreme insulin resistance and…”
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