Search Results - "Siddle, K"

Programming of adipose tissue miR-483-3p and GDF-3 expression by maternal diet in type 2 diabetes by Ferland-McCollough, D, Fernandez-Twinn, D S, Cannell, I G, David, H, Warner, M, Vaag, A A, Bork-Jensen, J, Brøns, C, Gant, T W, Willis, A E, Siddle, K, Bushell, M, Ozanne, S E

“…Nutrition during early mammalian development permanently influences health of the adult, including increasing the risk of type 2 diabetes and coronary heart…”
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The transcription factors Egr1 and Egr2 have opposing influences on adipocyte differentiation by Boyle, K B, Hadaschik, D, Virtue, S, Cawthorn, W P, Ridley, S H, O'Rahilly, S, Siddle, K

“…The zinc finger-containing transcription factors Egr1 (Krox24) and Egr2 (Krox20) have been implicated in the proliferation and differentiation of many cell…”
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Bases adjacent to mononucleotide repeats show an increased single nucleotide polymorphism frequency in the human genome by SIDDLE, K. J, GOODSHIP, J. A, KEAVNEY, B, SANTIBANEZ-KOREF, M. F

“…Mononucleotide repeats (MNRs) are abundant in eukaryotic genomes and exhibit a high degree of length variability due to insertion and deletion events. However,…”
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Tumor necrosis factor-alpha induces apoptosis of human adipose cells by Prins, J. B., Niesler, C. U., Winterford, C. M., Bright, N. A., Siddle, K., O'Rahilly, S., Walker, N. I., Cameron, D. P.

“…Tumor necrosis factor-alpha induces apoptosis of human adipose cells. J B Prins , C U Niesler , C M Winterford , N A Bright , K Siddle , S O'Rahilly , N I…”
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Specificity in ligand binding and intracellular signalling by insulin and insulin-like growth factor receptors by Siddle, K, Ursø, B, Niesler, C A, Cope, D L, Molina, L, Surinya, K H, Soos, M A

“…The physiological roles of insulin and insulin-like growth factors (IGFs) are distinct, with insulin acting to regulate cellular uptake and metabolism of…”
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Insulin receptor/IGF-I receptor hybrids are widely distributed in mammalian tissues: quantification of individual receptor species by selective immunoprecipitation and immunoblotting by Bailyes, E M, Navé, B T, Soos, M A, Orr, S R, Hayward, A C, Siddle, K

“…The insulin receptor (IR) and type 1 insulin-like growth factor (IGF-I) receptor (IGFR) are both widely expressed in mammalian tissues, and are known to be…”
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Human preadipocytes display a depot-specific susceptibility to apoptosis by C U Niesler, K Siddle, J B Prins

“…Human preadipocytes display a depot-specific susceptibility to apoptosis. C U Niesler , K Siddle and J B Prins Department of Clinical Biochemistry, University…”
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Insulin stimulation of glycogen synthesis and glycogen synthase activity is blocked by wortmannin and rapamycin in 3T3-L1 adipocytes: evidence for the involvement of phosphoinositide 3-kinase and p70 ribosomal protein-S6 kinase by Shepherd, P R, Navé, B T, Siddle, K

“…We have investigated the involvement of phosphoinositide (PI) 3-kinase and p70 ribosomal protein-S6 kinase (p70s6k) in mediating insulin stimulation of…”
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Defect in Insulin-Like Growth Factor-1 Survival Mechanism in Atherosclerotic Plaque-Derived Vascular Smooth Muscle Cells Is Mediated by Reduced Surface Binding and Signaling by Patel, V A, Zhang, Q.-J, Siddle, K, Soos, M A, Goddard, M, Weissberg, P L, Bennett, M R

“…ABSTRACT—Apoptosis of vascular smooth muscle cells (VSMCs) is increased in atherosclerosis compared with normal vessels, where it may contribute to plaque…”
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Can we prevent postnatal depression? A randomized controlled trial to assess the effect of continuity of midwifery care on rates of postnatal depression in high-risk women by Marks, M. N., Siddle, K., Warwick, C.

“…Objective: To evaluate the effectiveness of continuous midwifery care in reducing rates of postnatal depression in women with histories of depression. Methods:…”
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Purified hybrid insulin/insulin-like growth factor-I receptors bind insulin-like growth factor-I, but not insulin, with high affinity by SOOS, M. A, FIELD, C. E, SIDDLE, K

“…Hybrid insulin/insulin-like growth factor-I (IGF-I) receptors have previously been described in human placenta, but it has not been possible to study their…”
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IGF-I inhibits apoptosis induced by serum withdrawal, but potentiates TNF-alpha-induced apoptosis, in 3T3-L1 preadipocytes by Niesler, CU, Urso, B, Prins, JB, Siddle, K

“…We have previously shown that human preadipocytes in primary culture undergo apoptosis in response to serum deprivation and addition of tumour necrosis factor…”
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Nick Hales: an appreciation of his life and work by Siddle, K., Luzio, J. P., Ozanne, S. E.

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Contextual Assessment of the Maternity Experience: development of an instrument for cross-cultural research by Bernazzani, Odette, Conroy, Sue, Marks, Maureen N., Siddle, Kathryn A., Guedeney, Nicole, Bifulco, Antonia, Asten, Paul, Figueiredo, Barbara, Gorman, Laura L., Bellini, Simona, Glatigny-Dallay, Elisabeth, Hayes, Sandra, Klier, Claudia M., Kammerer, Martin H., Henshaw, Carol A.

“…There is evidence that stressors may trigger the onset of a depressive episode in vulnerable women. A new UK interview measure, the Contextual Assessment of…”
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Immunological relationships between receptors for insulin and insulin-like growth factor I. Evidence for structural heterogeneity of insulin-like growth factor I receptors involving hybrids with insulin receptors by Soos, M A, Siddle, K

“…The receptors for insulin and insulin-like growth factor-I (IGF-I) are closely related in primary sequence and overall structure. We have examined the…”
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Sensitive and specific two-site immunoradiometric assays for human insulin, proinsulin, 65-66 split and 32-33 split proinsulins by Sobey, W J, Beer, S F, Carrington, C A, Clark, P M, Frank, B H, Gray, I P, Luzio, S D, Owens, D R, Schneider, A E, Siddle, K

“…Monoclonal antibody-based two-site immunoradiometric assays are described for human insulin, proinsulin, 65-66 split and 32-33 split proinsulin. The detection…”
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Signaling-competent receptor chimeras allow mapping of major insulin receptor binding domain determinants by SCHUMACHER, R, SOOS, M. A, SCHLESSINGER, J, BRANDENBURG, D, SIDDLE, K, ULLRICH, A

“…Chimeric receptors were generated in which structurally defined subdomains of the insulin receptor (IR) and insulin growth factor-I receptor (IGF-1R)…”
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Involvement of phosphoinositide 3-kinase in insulin stimulation of MAP-kinase and phosphorylation of protein kinase-B in human skeletal muscle : implications for glucose metabolism by SHEPHERD, P. R, NAVE, B. T, RINCON, J, HAIGH, R. L, FOULSTONE, E, PROUD, C, ZIERATH, J. R, SIDDLE, K, WALLBERG-HENRIKSSON, H

“…Isolated skeletal muscle from healthy individuals was used to evaluate the role of phosphoinositide 3-kinase (PI 3-kinase) in insulin signalling pathways…”
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Receptors for insulin and insulin-like growth factor-I can form hybrid dimers. Characterisation of hybrid receptors in transfected cells by Soos, M A, Whittaker, J, Lammers, R, Ullrich, A, Siddle, K

“…We have demonstrated the formation of hybrid insulin/insulin-like growth factor-I(IGF-I) receptors in transfected rodent fibroblasts, which overexpress human…”
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Structural domains of the insulin receptor and IGF receptor required for dimerisation and ligand binding by Molina, L, Marino-Buslje, C, Quinn, D.R, Siddle, K

“…We investigated structural requirements for dimerisation and ligand binding of insulin/IGF receptors. Soluble receptor fragments consisting of N-terminal…”
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