Search Results - "Siddiqi, Suhaib M"
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1
Virtual terminator nucleotides for next-generation DNA sequencing
Published in Nature methods (01-08-2009)“…We synthesized reversible terminators with tethered inhibitors for next-generation sequencing. These were efficiently incorporated with high fidelity while…”
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2
Antiviral Enantiomeric Preference for 5'-Noraristeromycin
Published in Journal of medicinal chemistry (01-02-1994)“…In order to determine if the potent antiviral properties of (+/-)-5'-noraristeromycin reside in one of its enantiomers, an analysis of each enantiomer has been…”
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3
Capture compound mass spectrometry: a technology for the investigation of small molecule protein interactions
Published in Assay and drug development technologies (01-06-2007)“…One of the major hurdles in the post-genomic era is to understand the function of genes and the interplay of many different cellular proteins. This is…”
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4
Search for New Purine- and Ribose-Modified Adenosine Analogs as Selective Agonists and Antagonists at Adenosine Receptors
Published in Journal of medicinal chemistry (01-03-1995)“…The binding affinities at rat A1, A2a, and A3 adenosine receptors of a wide range of derivatives of adenosine have been determined. Sites of modification…”
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5
Structure-Activity Relationships of 9-Alkyladenine and Ribose-Modified Adenosine Derivatives at Rat A3 Adenosine Receptors
Published in Journal of medicinal chemistry (01-05-1995)“…9-Alkyladenine derivatives and ribose-modified N6-benzyladenosine derivatives were synthesized in an effort to identify selective ligands for the rat A3…”
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6
3-Deaza- and 7-Deaza-5'-noraristeromycin and Their Antiviral Properties
Published in Journal of medicinal chemistry (01-03-1995)“…An enantiospecific synthesis of 3-deaza-5'-noraristeromycin as its dihydrochloride ((-)-6) has been accomplished in six steps beginning with the reaction of…”
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7
An Epimer of 5'-Noraristeromycin and Its Antiviral Properties
Published in Journal of medicinal chemistry (01-04-1994)“…A derivative of 5'-noraristeromycin epimeric at the 5'-nor center ((-)-3) has been prepared enantiospecifically in three steps from…”
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8
Tetrahydrobenzothiophenone Derivatives as a Novel Class of Adenosine Receptor Antagonists
Published in Journal of medicinal chemistry (19-01-1996)“…A novel class of non-nitrogen-containing heterocycles, the tetrahydrobenzothiophenones, was found to bind to adenosine receptors as antagonists in the…”
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9
2-Substitution of N6-Benzyladenosine-5'-uronamides Enhances Selectivity for A3 Adenosine Receptors
Published in Journal of medicinal chemistry (14-10-1994)“…Adenosine derivatives bearing an N6-(3-iodobenzyl) group, reported to enhance the affinity of adenosine-5'-uronamide analogues as agonists at A3 adenosine…”
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10
Comparative molecular field analysis of selective A3 adenosine receptor agonists
Published in Bioorganic & medicinal chemistry (01-10-1995)“…A series of 48 N6-benzyladenosine 5'-uronamide derivatives has been described recently as moderately selective A3 adenosine receptor agonists of nanomolar…”
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11
Comparative molecular field analysis of selective A 3 adenosine receptor agonists
Published in Bioorganic & medicinal chemistry (1995)“…A series of 48 N 6-benzyladenosine 5′-uronamide derivatives has been described recently as moderately selective A 3 adenosine receptor agonists of nanomolar…”
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12
Synthesis of (1R,4S,5R)-endo-N,N-dimethyl-2-azabicyclo[2.2.1]methanamine
Published in Journal of heterocyclic chemistry (01-12-1991)“…Starting from trans‐4‐hydroxy‐L‐proline, (1R,4S,5R)‐endo‐N,N‐dimethyl‐2‐azabicyclo[2.2.1]methanamine 1 has been synthesized. The target compound is precursor…”
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