Search Results - "Siddals, Kirk W"

The Impact of Abnormalities in IGF and Inflammatory Systems on the Metabolic Syndrome by KAUSHAL, Kalpana, HEALD, Adrian H, SIDDALS, Kirk W, SANDHU, Manjinder S, DUNGER, David B, GIBSON, John M, WAREHAM, Nick J

“…The Impact of Abnormalities in IGF and Inflammatory Systems on the Metabolic Syndrome Kalpana Kaushal , MD 1 , Adrian H. Heald , DM 1 , Kirk W. Siddals , PHD 1…”
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Apposite Insulin-like Growth Factor (IGF) Receptor Glycosylation Is Critical to the Maintenance of Vascular Smooth Muscle Phenotype in the Presence of Factors Promoting Osteogenic Differentiation and Mineralization by Siddals, Kirk W., Allen, Justine, Sinha, Smeeta, Canfield, Ann E., Kalra, Philip A., Gibson, J. Martin

“…Vascular calcification is strongly linked with increased morbidity and mortality from cardiovascular disease. Vascular calcification is an active cell-mediated…”
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Abrogation of insulin-like growth factor-I (IGF-I) and insulin action by mevalonic acid depletion: synergy between protein prenylation and receptor glycosylation pathways by Siddals, Kirk W, Marshman, Emma, Westwood, Melissa, Gibson, J Martin

“…The vasculoprotective effects of hydroxy-3-methylglutaryl (HMG)-CoA reductase inhibitors (statins) correlate with cholesterol lowering. HMG-CoA reductase…”
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Reduced Pericellular Sensitivity to IGF-I in Fibroblasts From Girls With Turner Syndrome: A Mechanism to Impair Clinical Responses to GH by Westwood, Melissa, Tajbakhsh, Shahin H, Siddals, Kirk W, Whatmore, Andrew J, Clayton, Peter E

“…Girls with Turner syndrome (TS) are treated with supraphysiological doses of growth hormone (GH) to improve final height; however in some girls, the growth…”
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Insulin-like growth factor-II and insulin-like growth factor binding protein-2 prospectively predict longitudinal elevation of HDL-cholesterol in type 2 diabetes by Narayanan, Ram P, Fu, Bo, Oliver, Robert L, Siddals, Kirk W, Donn, Rachelle, Hudson, Julie E, White, Anne, Laing, Ian, Ollier, William E R, Heald, Adrian H, Gibson, J M

“…Associations of insulin-like growth factor-II (IGF-II) and insulin-like growth factor binding protein-2 (IGFBP-2) with cardiovascular risk have been…”
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Atorvastatin administration is associated with dose-related changes in IGF bioavailability by Narayanan, Ram P, Gittins, Matthew, Siddals, Kirk W, Oliver, Robert L, Hudson, Julie E, White, Anne, Durrington, Paul, Davies, Robert R, Rutter, Martin K, Gibson, J Martin

“…ObjectiveIGF levels, their binding proteins (IGFBPs) and high-dose statin therapy have been linked to the development of diabetes. We aimed to identify whether…”
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IGFBP2 is a biomarker for predicting longitudinal deterioration in renal function in type 2 diabetes by Narayanan, Ram P, Fu, Bo, Heald, Adrian H, Siddals, Kirk W, Oliver, Robert L, Hudson, Julie E, Payton, Antony, Anderson, Simon G, White, Anne, Ollier, William E R, Gibson, J Martin

“…ObjectiveInsulin-like growth factors are implicated in the development of diabetic nephropathy. IGF-binding protein 2 (IGFBP2) and IGF2 are expressed in the…”
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Abrogation of Insulin-like Growth Factor-I (IGF-I) and Insulin Action by Mevalonic Acid Depletion by Siddals, Kirk W., Marshman, Emma, Westwood, Melissa, Gibson, J. Martin

“…The vasculoprotective effects of hydroxy-3-methylglutaryl (HMG)-CoA reductase inhibitors (statins) correlate with cholesterol lowering. HMG-CoA reductase…”
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The effect of atorvastatin on serum lipoproteins in acromegaly by Mishra, Manoj, Durrington, Paul, Mackness, Mike, Siddals, Kirk W., Kaushal, Kalpana, Davies, Rob, Gibson, Martin, Ray, David W.

“…Objective Acromegaly is associated with long‐term adverse effects on cardiovascular mortality and morbidity. Reducing growth hormone secretion improves…”
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IGFBP2 is a biomarker for predicting longitudinal deterioration in renal function in type 2 diabetes by Narayanan, R. P., Fu, B., Heald, A. H., Siddals, K. W., Oliver, R. L., Hudson, J. E., Payton, A., Anderson, S. G., White, A., Ollier, W. E. R., Gibson, J. M.

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