Search Results - "Sidach, Serguei S"

Variability in the measurement of hERG potassium channel inhibition: Effects of temperature and stimulus pattern by Kirsch, Glenn E., Trepakova, Elena S., Brimecombe, Jessica C., Sidach, Serguei S., Erickson, Hope D., Kochan, Mary C., Shyjka, Lisa M., Lacerda, Antonio E., Brown, Arthur M.

“…In vitro evaluation of drug effects on hERG K + channels is a valuable tool for identifying potential proarrhythmic side effects in drug safety testing…”
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Kurtoxin, A Gating Modifier of Neuronal High- and Low-Threshold Ca Channels by Sidach, Serguei S, Mintz, Isabelle M

“…Studies of Ca channels expressed in oocytes have identified kurtoxin as a promising tool for functional and structural studies of low-threshold T-type Ca…”
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Structure–Activity Studies of 7‑Heteroaryl-3-azabicyclo[3.3.1]non-6-enes: A Novel Class of Highly Potent Nicotinic Receptor Ligands by Breining, Scott R, Melvin, Matt, Bhatti, Balwinder S, Byrd, Gary D, Kiser, Melanie N, Hepler, Christopher D, Hooker, Dawn N, Zhang, Jenny, Reynolds, Leslie A, Benson, Lisa R, Fedorov, Nikolai B, Sidach, Serguei S, Mitchener, J. Pike, Lucero, Linda M, Lukas, Ronald J, Whiteaker, Paul, Yohannes, Daniel

“…The potential for nicotinic ligands with affinity for the α4β2 or α7 subtypes to treat such diverse diseases as nicotine addiction, neuropathic pain, and…”
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Validation of a high-throughput, automated electrophysiology platform for the screening of nicotinic agonists and antagonists by Graef, John D, Benson, Lisa C, Sidach, Serguei S, Wei, Haiyang, Lippiello, Patrick M, Bencherif, Merouane, Fedorov, Nikolai B

“…High-throughput compound screening using electrophysiology-based assays represents an important tool for biomedical research and drug discovery programs. The…”
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Pharmacological properties and predicted binding mode of arylmethylene quinuclidine-like derivatives at the α3β4 nicotinic acetylcholine receptor (nAChR) by Kombo, David C., Hauser, Terry A., Grinevich, Vladimir P., Melvin, Matthew S., Strachan, Jon-Paul, Sidach, Serguei S., Chewning, Joseph, Fedorov, Nikolai, Tallapragada, Kartik, Breining, Scott R., Miller, Craig H.

“…We have carried out a pharmacological evaluation of arylmethylene quinuclidine derivatives interactions with human α3β4 nAChRs subtype, using cell-based…”
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Development and optimization of a high-throughput electrophysiology assay for neuronal alpha 4 beta 2 nicotinic receptors by Sidach, Serguei S, Fedorov, Nikolai B, Lippiello, Patrick M, Bencherif, Merouane

“…Historically, the identification of alpha 4 beta 2 nicotinic acetylcholine receptor ligands has been based on high-throughput radioligand binding, rubidium…”
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Low-Affinity Blockade of Neuronal N-Type Ca Channels by the Spider Toxin omega -Agatoxin-IVA by Sidach, Serguei S, Mintz, Isabelle M

“…The recognition of neuronal Ca channel diversity has led to considerable efforts to identify useful classification criteria. Here, we revisit the…”
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Abstract P273: Increased Inhibition of Potassium Channel Currents by Angiotensin II in Sympathetic Neurons may Contribute to a Sustained Blood Pressure Elevation in (mRen2)27 Rats by Sidach, Serguei S, Pulgar, Victor M, Aileru, Azeez A

“…Abstract only It is well established that the increased sympathetic tone may contribute to initiation and progression of various forms of hypertension. Several…”
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Abstract P344: Increased Expression and Function of Endothelin Receptors in Aorta of (mRen2)27 Hypertensive Rats by Pulgar, Victor M, Ademoyero, Oludamilola T, Sidach, Serguei S, Aileru, Azeez A

“…Abstract only Endothelin-1 (ET-1) contributes to various cardiovascular diseases including hypertension. ET-1 is produced in the endothelium and acts via ET A…”
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A methodological comparison of human α4β2 and α3β4 receptor properties using conventional and high-throughput patch-clamp electrophysiology techniques by Benson, Lisa C., Sidach, Serguei S., Graef, John D., Lippiello, Patrick M., Bencherif, Merouane, Fedorov, Nikolai B.

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Development and optimization of a high-throughput electrophysiology assay for neuronal α4β2 nicotinic receptors by Sidach, Serguei S., Fedorov, Nikolai B., Lippiello, Patrick M., Bencherif, Merouane

“…Historically, the identification of α4β2 nicotinic acetylcholine receptor ligands has been based on high-throughput radioligand binding, rubidium efflux assays…”
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Development and optimization of a high-throughput electrophysiology assay for neuronal alpha4beta2 nicotinic receptors by Sidach, Serguei S, Fedorov, Nikolai B, Lippiello, Patrick M, Bencherif, Merouane

“…Historically, the identification of alpha4beta2 nicotinic acetylcholine receptor ligands has been based on high-throughput radioligand binding, rubidium efflux…”
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Gating modifications of neuronal voltage-activated calcium channels by peptide toxins by Sidach, Serguei S

“…Animal venoms contain a diversity of protein toxins designed for fast immobilization of the prey. Many of these toxins target voltage-gated calcium channels…”
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Gating modifications of neuronal voltage -activated calcium channels by peptide toxins by Sidach, Serguei S

“…Animal venoms contain a diversity of protein toxins designed for fast immobilization of the prey. Many of these toxins target voltage-gated calcium channels…”
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