Search Results - "Sickmann, A"

Combination of Proteogenomics with Peptide De Novo Sequencing Identifies New Genes and Hidden Posttranscriptional Modifications by Blank-Landeshammer, B, Teichert, I, Märker, R, Nowrousian, M, Kück, U, Sickmann, A

“…Proteogenomics combines proteomics, genomics, and transcriptomics and has considerably improved genome annotation in poorly investigated phylogenetic groups…”
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Phosphorylation of CalDAG‐GEFI by protein kinase A prevents Rap1b activation by Subramanian, H., Zahedi, R. P., Sickmann, A., Walter, U., Gambaryan, S.

“…Summary Background Signaling via protein kinase A (PKA) and protein kinase G (PKG) is critical for maintaining platelets in the resting state. Both kinases…”
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Nuclear import of LASP-1 is regulated by phosphorylation and dynamic protein–protein interactions by Mihlan, S, Reiß, C, Thalheimer, P, Herterich, S, Gaetzner, S, Kremerskothen, J, Pavenstädt, H J, Lewandrowski, U, Sickmann, A, Butt, E

“…LASP-1 is a multidomain protein predominantly localized at focal contacts, where it regulates cytoskeleton dynamics and cell migration. However, in different…”
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Overexpression of LASP-1 mediates migration and proliferation of human ovarian cancer cells and influences zyxin localisation by Grunewald, T G P, Kammerer, U, Winkler, C, Schindler, D, Sickmann, A, Honig, A, Butt, E

“…LIM and SH3 protein 1 (LASP-1), initially identified from human breast cancer, is a specific focal adhesion protein involved in cell proliferation and…”
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Raf kinases mediate the phosphorylation of eukaryotic translation elongation factor 1A and regulate its stability in eukaryotic cells by Sanges, C, Scheuermann, C, Zahedi, R P, Sickmann, A, Lamberti, A, Migliaccio, N, Baljuls, A, Marra, M, Zappavigna, S, Reinders, J, Rapp, U, Abbruzzese, A, Caraglia, M, Arcari, P

“…We identified eukaryotic translation elongation factor 1A (eEF1A) Raf-mediated phosphorylation sites and defined their role in the regulation of eEF1A…”
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Bottom-up proteomics suggests an association between differential expression of mitochondrial proteins and chronic fatigue syndrome by Ciregia, F, Kollipara, L, Giusti, L, Zahedi, R P, Giacomelli, C, Mazzoni, M R, Giannaccini, G, Scarpellini, P, Urbani, A, Sickmann, A, Lucacchini, A, Bazzichi, L

“…Chronic fatigue syndrome (CFS) is a debilitating and complex disorder characterized by unexplained fatigue not improved by rest. An area of investigation is…”
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Protein Import Channel of the Outer Mitochondrial Membrane: a Highly Stable Tom40-Tom22 Core Structure Differentially Interacts with Preproteins, Small Tom Proteins, and Import Receptors by Meisinger, Chris, Ryan, Michael T., Hill, Kerstin, Model, Kirstin, Lim, Joo Hyun, Sickmann, Albert, Müller, Hanne, Meyer, Helmut E., Wagner, Richard, Pfanner, Nikolaus

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Conformational Switch and Role of Phosphorylation in PAK Activation by Buchwald, Gretel, Hostinova, Eva, Rudolph, Markus G., Kraemer, Astrid, Sickmann, Albert, Meyer, Helmut E., Scheffzek, Klaus, Wittinghofer, Alfred

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Identification of an obeche (Triplochiton scleroxylon) wood allergen as a class I chitinase by Kespohl, S., Sander, I., Merget, R., Petersen, A., Meyer, H. E., Sickmann, A., Bruening, T., Raulf‐Heimsoth, M.

“…Background:  Wood dust is known to cause allergic occupational asthma and obeche (Triplochiton scleroxylon) is a prominent exponent in this field. However, the…”
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Raf kinases mediate the phosphorylation of eukaryotic translation elongation factor 1A and regulate its stability in eukaryotic cells by Sanges, C, Scheuermann, C, Zahedi, R P, Sickmann, A, Lamberti, A, Migliaccio, N, Baljuls, A, Marra, M, Zappavigna, S, Reinders, J, Rapp, U, Abbruzzese, A, Caraglia, M, Arcari, P

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State-of-the-art in phosphoproteomics by Reinders, Joerg, Sickmann, Albert

“…Presently, phosphorylation of proteins is the most studied and best understood PTM. However, the analysis of phosphoproteins and phosphopeptides is still one…”
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Functional proteome analysis of human platelets by Lewandrowski, U, Zahedi, R P, Moebius, J, Sickmann, A

“…Platelets are anucleated cells and therefore ideal research objects for modern proteome analyses. Despite their importance in thrombosis and hemostasis the…”
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Is lumican responsible for the low angiogenetic potential of the adult mammalian heart? by Alfi, E, Kocijan, T, Colliva, A, Abdelaleem, GHA, Shevchuk, O, Vodret, S, Myers, M, Sickmann, A, Zacchigna, S

“…Abstract Funding Acknowledgements Type of funding sources: Foundation. Main funding source(s): AIRC Introduction Adult mammals fail to regenerate the…”
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Regulation of the glucose-specific phosphotransferase system (PTS) of Staphylococcus carnosus by the antiterminator protein GlcT by Knezevic, Igor, Bachem, Steffi, Sickmann, Albert, Meyer, Helmut E, Stulke, Jorg, Hengstenberg, Wolfgang

“…AG Physiologie der Mikroorganismen, Ruhr-Universität Bochum, ND 06/744, Universitätsstr. 150, D-44780 Bochum, Germany 1 Lehrstuhl für Mikrobiologie, Institut…”
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AUTOPHAGIC MYOPATHIES / MYOFIBRILLAR MYOPATHIES / DISTAL MYOPATHIES / POMPE DISEASE by Hentschel, A., Pogoryelova, O., Sickmann, A., Schara, U., Lochmüller, H., Roos, A.

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AUTOPHAGIC MYOPATHIES / MYOFIBRILLAR MYOPATHIES / DISTAL MYOPATHIES / POMPE DISEASE: P.08 Fibroblasts as a suitable biomaterial to study the etiology of neuromuscular diseases by Hentschel, A., Pogoryelova, O., Sickmann, A., Schara, U., Lochmüller, H., Roos, A.

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Amyloid-β Peptide Induces Mitochondrial Dysfunction by Inhibition of Preprotein Maturation by Mossmann, Dirk, Vögtle, F.-Nora, Taskin, Asli Aras, Teixeira, Pedro Filipe, Ring, Julia, Burkhart, Julia M., Burger, Nils, Pinho, Catarina Moreira, Tadic, Jelena, Loreth, Desiree, Graff, Caroline, Metzger, Friedrich, Sickmann, Albert, Kretz, Oliver, Wiedemann, Nils, Zahedi, René P., Madeo, Frank, Glaser, Elzbieta, Meisinger, Chris

“…Most mitochondrial proteins possess N-terminal presequences that are required for targeting and import into the organelle. Upon import, presequences are…”
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Defective glycosylation of coagulation factor XII underlies hereditary angioedema type III by Björkqvist, Jenny, de Maat, Steven, Lewandrowski, Urs, Di Gennaro, Antonio, Oschatz, Chris, Schönig, Kai, Nöthen, Markus M, Drouet, Christian, Braley, Hal, Nolte, Marc W, Sickmann, Albert, Panousis, Con, Maas, Coen, Renné, Thomas

“…Hereditary angioedema type III (HAEIII) is a rare inherited swelling disorder that is associated with point mutations in the gene encoding the plasma protease…”
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VP.20 Cathepsin D as biomarker in CSF of nusinersen-treated patients with spinal muscular atrophy by Schorling, D., Kölbel, H., Hentschel, A., Pechmann, A., Meyer, N., Wirth, B., Rombo, R., Consortium, A. SMArtCARE, Sickmann, A., Kirschner, J., Schara-Schmidt, U., Lochmüller, H., Roos, A.

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ANXA7 Regulates Platelet Lipid Metabolism and Ca2+ Release in Arterial Thrombosis by Manke, Mailin-Christin, Geue, Sascha, Coman, Cristina, Peng, Bing, Kollotzek, Ferdinand, Münzer, Patrick, Walker, Britta, Huber, Stephan M., Rath, Dominik, Sickmann, Albert, Stegner, David, Duerschmied, Daniel, Lang, Florian, Nieswandt, Bernhard, Gawaz, Meinrad, Ahrends, Robert, Borst, Oliver

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