Search Results - "Sick, T J"

Anoxic preconditioning in hippocampal slices: role of adenosine by Péerez-pinzón, M.A., Mumford, P.L., Rosenthal, M., Sick, T.J.

“…Prior studies have shown that sublethal anoxic/ischemic insults may “precondition” and thereby protect tissues such as heart and brain from subsequent insults…”
Get full text

Rapid preconditioning protects rats against ischemic neuronal damage after 3 but not 7 days of reperfusion following global cerebral ischemia by Pérez-Pinzón, M A, Xu, G P, Dietrich, W D, Rosenthal, M, Sick, T J

“…Earlier studies indicated that sublethal ischemic insults separated by many hours may "precondition" and, thereby, protect tissues from subsequent insults. In…”
Get more information

Ischemic Preconditioning Preserves Mitochondrial Function After Global Cerebral Ischemia in Rat Hippocampus by Dave, Kunjan R., Saul, Isabel, Busto, Raul, Ginsberg, Myron D., Sick, Thomas J., Pérez-Pinzón, Miguel A.

“…Ischemic tolerance in brain develops when sublethal ischemic insults occur before “lethal” cerebral ischemia. Two windows for the induction of tolerance by…”
Get full text

Cytochrome C Is Released from Mitochondria Into the Cytosol after Cerebral Anoxia or Ischemia by Pérez-Pinzón, Miguel A., Xu, Guang Ping, Born, James, Lorenzo, José, Busto, Raul, Rosenthal, Myron, Sick, Thomas J.

“…Mitochondrial dysfunction may underlie both acute and delayed neuronal cell death resulting from cerebral ischemia. Specifically, postischemic release of…”
Get full text

Chronic failure in the maintenance of long-term potentiation following fluid percussion injury in the rat by Sanders, Matthew J, Sick, Thomas J, Perez-Pinzon, Miguel A, Dietrich, W.Dalton, Green, Edward J

“…Traumatic brain injury (TBI) can produce chronic cognitive learning/memory deficits that are thought to be mediated, in part, by impaired hippocampal function…”
Get full text

Nitric oxide is involved in anoxic preconditioning neuroprotection in rat hippocampal slices by Centeno, José M., Orti, Marta, Salom, Juan B., Sick, Thomas J., Pérez-Pinzón, Miguel A.

“…Sublethal anoxia/ischemia protects against subsequent damaging insults in intact brain or hippocampal slices. To help further understand mechanisms underlying…”
Get full text

Impaired expression of long-term potentiation in hippocampal slices 4 and 48 h following mild fluid-percussion brain injury in vivo by Sick, Thomas J., Pérez-Pinzón, Miguel A., Feng, Zhen-Zhou

“…The effect of fluid percussion brain injury on hippocampal long-term potentiation (LTP) was investigated in hippocampal slices in vitro. Mild to moderate…”
Get full text

Downregulation of sodium channels during anoxia: a putative survival strategy of turtle brain by Pérez-Pinzón, M A, Rosenthal, M, Sick, T J, Lutz, P L, Pablo, J, Mash, D

“…In contrast to mammalian brain, which exhibits rapid degeneration during anoxia, the brains of certain species of turtles show an extraordinary capacity to…”
Get full text

epsilon PKC Is Required for the Induction of Tolerance by Ischemic and NMDA-Mediated Preconditioning in the Organotypic Hippocampal Slice by Raval, Ami P, Dave, Kunjan R, Mochly-Rosen, Daria, Sick, Thomas J, Perez-Pinzon, Miguel A

“…Glutamate receptors and calcium have been implicated as triggering factors in the induction of tolerance by ischemic preconditioning (IPC) in the brain…”
Get full text

Adenosine, a "retaliatory" metabolite, promotes anoxia tolerance in turtle brain by Pérez-Pinzón, M A, Lutz, P L, Sick, T J, Rosenthal, M

“…Contrary to what is found in most vertebrates, the brains of certain turtle species maintain ATP levels and ion homeostasis and survive prolonged anoxia. The…”
Get more information

Calcium influx from the extracellular space promotes NADH hyperoxidation and electrical dysfunction after anoxia in hippocampal slices by Pérez-Pinzón, M A, Mumford, P L, Carranza, V, Sick, T J

“…A characteristic event during reperfusion after cerebral ischemia in vivo, and reoxygenation after anoxia in vitro, is hyperoxidation of the electron carriers…”
Get more information

The effect of rapid preconditioning on the microglial, astrocytic and neuronal consequences of global cerebral ischemia by PEREZ-PINZON, M. A, VITRO, T. M, DIETRICH, W. D, SICK, T. J

“…Previous studies indicated preconditioning of the brain with sublethal ischemic insults separated by many hours, protected tissues from a subsequent lethal…”
Get full text

Oxygen sensitivity of mitochondrial redox status and evoked potential recovery early during reperfusion in post-ischemic rat brain by Feng, Zi-Cai, Sick, Thomas J, Rosenthal, Myron

“…Inspired oxygen (FiO2) was manipulated during the early reperfusion period after global cerebral ischemia (four-vessel occlusion of 20 or 30 min duration) in…”
Get full text

Spatial stability of extracellular potassium ion and blood flow distribution in rat cerebral cortex after permanent middle cerebral artery occlusion by Sick, T J, Feng, Z C, Rosenthal, M

“…Extracellular potassium ion activity ([K+]o) increases precipitously during brain ischemia when blood flow falls below threshold values less than approximately…”
Get more information

Prolonged anoxic depolarization exacerbates NADH hyperoxidation and promotes poor electrical recovery after anoxia in hippocampal slices by Pérez-Pinzón, Miguel A, Mumford, Patricia L, Sick, Thomas J

“…Mitochondrial dysfunction appears to occur during brain ischemia and following reperfusion. A characteristic event during reoxygenation after anoxia in…”
Get full text

Mitochondrial hyperoxidation signals residual intracellular dysfunction after global ischemia in rat neocortex by Rosenthal, M, Feng, Z C, Raffin, C N, Harrison, M, Sick, T J

“…Reperfusion after global ischemia (10-60 min in duration) in rat neocortex most commonly provoked transient hyperoxidation of mitochondrial electron carriers,…”
Get more information

Membrane and synaptic activity during anoxia in the isolated turtle cerebellum by Pérez-Pinzón, M A, Chan, C Y, Rosenthal, M, Sick, T J

“…Electrical depression in the turtle brain during anoxia has been suggested as a strategy for sparing energy and promoting the extraordinary survival capacity…”
Get full text

Aging impairs regulation of intracellular pH in rat hippocampal slices by Roberts, Eugene L., Sick, Thomas J.

“…We investigated whether aging changed H + homeostasis in hippocampal slices bathed in HEPES buffer. Intracellular pH in hippocampal slices from rats aged 26–27…”
Get full text

Cerebral blood flow does not mediate the effect of brain temperature on recovery of extracellular potassium ion activity after transient focal ischemia in the rat by Sick, Thomas J, Tang, Ruixia, Pérez-Pinzón, Miguel A

“…Temperature plays an important role in determining outcome following both global and focal brain ischemia. After focal ischemia, the degree of infarction…”
Get full text

Protein Aggregation After Focal Brain Ischemia and Reperfusion by Hu, Bing-Ren, Janelidze, Shorena, Ginsberg, Myron D., Busto, Raul, Perez-Pinzon, Miguel, Sick, Thomas J., Siesjö, Bo K., Liu, C. L.

“…Two hours of transient focal brain ischemia causes acute neuronal death in the striatal core region and a somewhat more delayed type of neuronal death in…”
Get full text