Search Results - "Sicart, Adria"

PLCγ1 Participates in Protein Transport and Diacylglycerol Production Triggered by cargo Arrival at the Golgi by Sicart, Adrià, Katan, Matilda, Egea, Gustavo, Sarri, Elisabet

“…Diacylglycerol (DAG) is required for membrane traffic and structural organization at the Golgi. DAG is a lipid metabolite of several enzymatic reactions…”
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Differentiation but not ALS mutations in FUS rewires motor neuron metabolism by Vandoorne, Tijs, Veys, Koen, Guo, Wenting, Sicart, Adria, Vints, Katlijn, Swijsen, Ann, Moisse, Matthieu, Eelen, Guy, Gounko, Natalia V., Fumagalli, Laura, Fazal, Raheem, Germeys, Christine, Quaegebeur, Annelies, Fendt, Sarah-Maria, Carmeliet, Peter, Verfaillie, Catherine, Van Damme, Philip, Ghesquière, Bart, De Bock, Katrien, Van Den Bosch, Ludo

“…Energy metabolism has been repeatedly linked to amyotrophic lateral sclerosis (ALS). Yet, motor neuron (MN) metabolism remains poorly studied and it is unknown…”
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Phospholipid Synthesis Participates in the Regulation of Diacylglycerol Required for Membrane Trafficking at the Golgi Complex by Sarri, Elisabet, Sicart, Adrià, Lázaro-Diéguez, Francisco, Egea, Gustavo

“…The lipid metabolite diacylglycerol (DAG) is required for transport carrier biogenesis at the Golgi, although how cells regulate its levels is not well…”
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βIII Spectrin Regulates the Structural Integrity and the Secretory Protein Transport of the Golgi Complex by Salcedo-Sicilia, Laia, Granell, Susana, Jovic, Marko, Sicart, Adrià, Mato, Eugenia, Johannes, Ludger, Balla, Tamas, Egea, Gustavo

“…A spectrin-based cytoskeleton is associated with endomembranes, including the Golgi complex and cytoplasmic vesicles, but its role remains poorly understood…”
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Targeting EGLN2/PHD1 protects motor neurons and normalizes the astrocytic interferon response by Germeys, Christine, Vandoorne, Tijs, Davie, Kristofer, Poovathingal, Suresh, Heeren, Kara, Vermeire, Wendy, Nami, FatemehArefeh, Moisse, Matthieu, Quaegebeur, Annelies, Sierksma, Annerieke, Rué, Laura, Sicart, Adrià, Eykens, Caroline, De Cock, Lenja, De Strooper, Bart, Carmeliet, Peter, Van Damme, Philip, De Bock, Katrien, Van Den Bosch, Ludo

“…Neuroinflammation and dysregulated energy metabolism are linked to motor neuron degeneration in amyotrophic lateral sclerosis (ALS). The egl-9 family…”
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C9orf72-generated poly-GR and poly-PR do not directly interfere with nucleocytoplasmic transport by Vanneste, Joni, Vercruysse, Thomas, Boeynaems, Steven, Sicart, Adria, Van Damme, Philip, Daelemans, Dirk, Van Den Bosch, Ludo

“…Repeat expansions in the C9orf72 gene cause amyotrophic lateral sclerosis and frontotemporal dementia characterized by dipeptide-repeat protein (DPR)…”
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PP2A and GSK3 act as modifiers of FUS-ALS by modulating mitochondrial transport by Tziortzouda, Paraskevi, Steyaert, Jolien, Scheveneels, Wendy, Sicart, Adria, Stoklund Dittlau, Katarina, Barbosa Correia, Adriana Margarida, Burg, Thibaut, Pal, Arun, Hermann, Andreas, Van Damme, Philip, Moens, Thomas G., Van Den Bosch, Ludo

“…Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease which currently lacks effective treatments. Mutations in the RNA-binding protein FUS…”
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Torsins Are Essential Regulators of Cellular Lipid Metabolism by Grillet, Micheline, Dominguez Gonzalez, Beatriz, Sicart, Adria, Pöttler, Maria, Cascalho, Ana, Billion, Karolien, Hernandez Diaz, Sergio, Swerts, Jef, Naismith, Teresa V., Gounko, Natalia V., Verstreken, Patrik, Hanson, Phyllis I., Goodchild, Rose E.

“…Torsins are developmentally essential AAA+ proteins, and mutation of human torsinA causes the neurological disease DYT1 dystonia. They localize in the ER…”
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Actin Filaments Are Involved in the Coupling of V0-V1 Domains of Vacuolar H+-ATPase at the Golgi Complex by Serra-Peinado, Carla, Sicart, Adrià, Llopis, Juan, Egea, Gustavo

“…We previously reported that actin-depolymerizing agents promote the alkalization of the Golgi stack and the trans-Golgi network. The main determinant of acidic…”
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Actin filaments are involved in the functional coupling of Vo-V1 domains of vacuolar H-ATPase at the Golgi complex by Serra-Peinado, Carla, Sicart, Adrià, Llopis, Juan, Egea Guri, Gustavo

“…We previously reported that actin-depolymerizing agents promote the alkalization of the Golgi stack and thetrans-Golgi network. The main determinant of acidic…”
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PLC[gamma]1 Participates in Protein Transport and Diacylglycerol Production Triggered by cargo Arrival at the Golgi by Sicart, Adrià, Katan, Matilda, Egea, Gustavo, Sarri, Elisabet

“…Diacylglycerol (DAG) is required for membrane traffic and structural organization at the Golgi. DAG is a lipid metabolite of several enzymatic reactions…”
Get full text