The influence of polyimide MP-1™ wear particles on a rodent closed fracture healing model

The influence of polyimide MP-1™ wear particles on a rodent closed fracture healing model

Joint replacements provide pain free movement for the injured or our aging population. Current prothesis mainly consist of hard metal on metal, or ceramic femoral head on ultra-high-molecular weight polyethylene (UHMWPE). In this study, a rodent fracture model was used to test the influence of wear...

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Bibliographic Details
Published in:Journal of applied biomaterials & functional materials Vol. 22; p. 22808000241240296
Main Authors: Oliver, Rema A, Wang, Tian, Christou, Chris, Buchman, Alisa, Sibony, Simha, Walsh, William R
Format: Journal Article
Language:English
Published: United States SAGE Publishing 01-01-2024
Subjects:
Aged
Animals
Fracture Healing
Hip Prosthesis - adverse effects
Humans
Macrophages
Polyethylenes - adverse effects
Prosthesis Failure
Rats
Rats, Sprague-Dawley
X-Ray Microtomography
wear
Polyimide
implants
fracture healing
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Summary:Joint replacements provide pain free movement for the injured or our aging population. Current prothesis mainly consist of hard metal on metal, or ceramic femoral head on ultra-high-molecular weight polyethylene (UHMWPE). In this study, a rodent fracture model was used to test the influence of wear debris from a high-performance polymer (polyimide MP-1™). Saline, MP-1™ Low Dose in Saline (1%), or MP-1 High Dose (2%) in Saline was injected directly into a standard closed unilateral femoral fracture in 12-week old Sprague Dawley rats (  = 25) for 1, 3 and 6 weeks. Endpoints included radiography, micro-computed tomography, mechanical testing and paraffin histology. No adverse effects from the wear particles were observed from the current study based on radiology, mechanical or histological data. Although the particles were present, histological analysis revealed a progression in healing between the Polyimide treated groups and the non-treated saline control groups over the duration of 1, 3, and 6 weeks, with no inhibition from the particles. The MP-1™ wear debris generated are larger than 1 µm thus are not able to be engulfed by macrophages and cause osteolysis. This family of polymers (polyimides) may be an ideal material to consider for articulating joints and other implants in the human body.
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ISSN:2280-8000
2280-8000
DOI:10.1177/22808000241240296