Search Results - "Sibley, CH"

Association of mutations in the Plasmodium falciparum Kelch13 gene (Pf3D7_1343700) with parasite clearance rates after artemisinin-based treatments-a WWARN individual patient data meta-analysis by Amaratunga, Chanaki, Andrianaranjaka, Voahangy Hanitriniaina, Ashley, Elizabeth, Bethell, Delia, Bjorkman, Anders, Bonnington, Craig A., Cooper, Roland A., Dhorda, Mehul, Dondorp, Arjen, Erhart, Annette, Fairhurst, Rick M., Faiz, Abul, Fanello, Caterina, Fukuda, Mark M., Guerin, Philippe, van Huijsduijnen, Rob Hooft, Hien, Tran Tinh, Hong, N. V., Htut, Ye, Huang, Fang, Humphreys, Georgina, Imwong, Mallika, Kennon, Kalynn, Lim, Pharath, Lin, Khin, Lon, Chanthap, Mårtensson, Andreas, Mayxay, Mayfong, Mokuolu, Olugbenga, Morris, Ulrika, Ngasala, Billy E., Amambua-Ngwa, Alfred, Noedl, Harald, Nosten, Francois, Onyamboko, Marie, Phyo, Aung Pyae, Plowe, Christopher V., Pukrittayakamee, Sasithon, Randrianarivelojosia, Milijaona, Rosenthal, Philip J., Saunders, David L., Sibley, Carol Hopkins, Smithuis, Frank, Spring, Michele D., Sondo, Paul, Sreng, Sokunthea, Starzengruber, Peter, Stepniewska, Kasia, Suon, Seila, Takala-Harrison, Shannon, Thriemer, Kamala, Thuy-Nhien, Nguyen, Tun, Kyaw Myo, White, Nicholas J., Woodrow, Charles

“…Plasmodium falciparum infections with slow parasite clearance following artemisinin-based therapies are widespread in the Greater Mekong Subregion. A molecular…”
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Gametocyte carriage in uncomplicated Plasmodium falciparum malaria following treatment with artemisinin combination therapy: a systematic review and meta-analysis of individual patient data by Bassat Orellana, Quique, González, Raquel, Menéndez, Clara, WWARN Gametocyte Study Group

“…Gametocytes are responsible for transmission of malaria from human to mosquito. Artemisinin combination therapy (ACT) reduces post-treatment gametocyte…”
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The effect of dose on the antimalarial efficacy of artemether–lumefantrine: a systematic review and pooled analysis of individual patient data by Price, RN, Davis, TME, Karunajeewa, HA, Mueller, I, Massougbodji, A, Nikiema, F, Ouedraogo, JB, Zongo, I, Same-Ekobo, A, Kone, M, Menan, H, Toure, AO, Kofoed, PE, Alemayehu, BH, Schramm, B, Deloron, P, Lell, B, Borrmann, S, Adjei, GO, Ursing, J, Tjitra, E, Marsh, K, Juma, E, Omar, SA, Talisuna, AO, Khanthavong, M, Mayxay, M, Newton, PN, Doumbo, OK, Fofana, B, Bassat, Q, Gonzalez, R, Menendez, C, Smithuis, F, Bousema, T, Kager, PA, Mens, PF, Schallig, HDFH, Van Vugt, M, Ibrahim, ML, Falade, CO, Meremikwu, M, Gil, JP, Karema, C, Ba, MS, Faye, B, Faye, O, Gaye, O, Ndiaye, JL, Pene, M, Sow, D, Sylla, K, Tine, RCK, Penali, LK, Barnes, KI, Workman, LJ, Lima, A, Adam, I, Gadalla, NB, Malik, EFM, Ngasala, BE, Rombo, L, Duparc, S, Filler, S, Genton, B, Hodel, EM, Olliaro, P, Abdulla, S, Shekalaghe, SA, Ashley, EA, Carrara, VI, McGready, R, Nosten, F, Lee, SJ, Dondorp, AM, Smith, JJ, Achan, J, Bukirwa, H, Yeka, A, Arinaitwe, E, Kamya, MR, Kironde, F, Oguike, M, Sutherland, CJ, Checchi, F, Guerin, PJ, Moreira, C, Nsanzabana, C, Sibley, CH, Stepniewska, K, Gething, PW, Hay, SI, Ward, SA, Winstanley, PA, Greenhouse, B, Rosenthal, PJ, Grivoyannis, A, Hwang, J, Kachur, PS, Nambozi, M

“…Summary Background Artemether–lumefantrine is the most widely used artemisinin-based combination therapy for malaria, although treatment failures occur in some…”
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Challenges for achieving safe and effective radical cure of Plasmodium vivax: a round table discussion of the APMEN Vivax Working Group by Thriemer, Kamala, Ley, Benedikt, Bobogare, Albino, Dysoley, Lek, Alam, Mohammad Shafiul, Pasaribu, Ayodhia P, Sattabongkot, Jetsumon, Jambert, Elodie, Domingo, Gonzalo J, Commons, Robert, Auburn, Sarah, Marfurt, Jutta, Devine, Angela, Aktaruzzaman, Mohammad M, Sohel, Nayeem, Namgay, Rinzin, Drukpa, Tobgyel, Sharma, Surender Nath, Sarawati, Elvieda, Samad, Iriani, Theodora, Minerva, Nambanya, Simone, Ounekham, Sonesay, Mudin, Rose Nanti Binti, Da Thakur, Garib, Makita, Leo Sora, Deray, Raffy, Lee, Sang-Eun, Boaz, Leonard, Danansuriya, Manjula N, Mudiyanselage, Santha D, Chinanonwait, Nipon, Kitchakarn, Suravadee, Nausien, Johnny, Naket, Esau, Duc, Thang Ngo, Do Manh, Ha, Hong, Young S, Cheng, Qin, Richards, Jack S, Kusriastuti, Rita, Satyagraha, Ari, Noviyanti, Rintis, Ding, Xavier C, Khan, Wasif Ali, Swe Phru, Ching, Guoding, Zhu, Qi, Gao, Kaneko, Akira, Miotto, Olivo, Nguitragool, Wang, Roobsoong, Wanlapa, Battle, Katherine, Howes, Rosalind E, Roca-Feltrer, Arantxa, Duparc, Stephan, Bhowmick, Ipsita Pal, Kenangalem, Enny, Bibit, Jo-Anne, Barry, Alyssa, Sintasath, David, Abeyasinghe, Rabindra, Sibley, Carol H, McCarthy, James, von Seidlein, Lorenz, Baird, J Kevin, Price, Ric N

“…The delivery of safe and effective radical cure for Plasmodium vivax is one of the greatest challenges for achieving malaria elimination from the Asia-Pacific…”
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Fighting drug-resistant Plasmodium falciparum: the challenge of artemisinin resistance by Wongsrichanalai, C., Sibley, C.H.

“…Following a decade-long scale up of malaria control through vector control interventions, the introduction of rapid diagnostic tests and highly efficacious…”
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Antifolates can have a role in the treatment of Plasmodium vivax by Hawkins, Vivian N, Joshi, Hema, Rungsihirunrat, Kanchana, Na-Bangchang, Kesara, Sibley, Carol Hopkins

“…Plasmodium vivax is a serious health concern in many regions and is sometimes inadvertently treated with sulfadoxine–pyrimethamine (SP). Mutations in the genes…”
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Malaria control in India: A national perspective in a regional and global fight to eliminate malaria by Guerin, P, Dhorda, M, Ganguly, N, Sibley, C

“…Since the declaration of the vision of malaria eradication in 2007, the overall burden of malaria has been reduced substantially in many countries in the…”
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Geographical Distribution of Amino Acid Mutations in Plasmodium vivax DHFR and DHPS from Malaria Endemic Areas of Thailand by Rungsihirunrat, Kanchana, Sibley, Carol Hopkins, Mungthin, Mathirut, Na-Bangchang, Kesara

“…Both malaria treatment and prophylaxis target the parasite dihydropteroate synthase (DHPS) and dihydrofolate reductase (DHFR) enzymes. Specific point mutations…”
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Pyrimethamine–sulfadoxine resistance in Plasmodium falciparum: what next? by Sibley, Carol Hopkins, Hyde, John E, Sims, Paul F.G, Plowe, Christopher V, Kublin, James G, Mberu, Edward K, Cowman, Alan F, Winstanley, Peter A, Watkins, William M, Nzila, Alexis M

“…Chemotherapy remains the only practicable tool to control falciparum malaria in sub-Saharan Africa, where >90% of the world's burden of malaria mortality and…”
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A network to monitor antimalarial drug resistance: a plan for moving forward by Sibley, Carol Hopkins, Barnes, Karen I, Watkins, William M, Plowe, Christopher V

“…The spread of resistance to antimalarial drugs has required changes in the recommended first-line treatment for falciparum malaria in almost all regions. Most…”
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Structure of the Mycobacterium tuberculosis Flavin Dependent Thymidylate Synthase (MtbThyX) at 2.0 Å Resolution by Sampathkumar, Parthasarathy, Turley, Stewart, Ulmer, Jonathan E., Rhie, Ho Gun, Sibley, Carol Hopkins, Hol, Wim G.J.

“…A novel flavin-dependent thymidylate synthase was identified recently as an essential gene in many archaebacteria and some pathogenic eubacteria. This enzyme,…”
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Pyrimethamine and WR99210 Exert Opposing Selection on Dihydrofolate Reductase from Plasmodium vivax by Hastings, Michele D., Sibley, Carol Hopkins

“…Plasmodium vivax is a major public health problem in Asia and South and Central America where it is most prevalent. Until very recently, the parasite has been…”
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Global resistance surveillance: ensuring antimalarial efficacy in the future by Guerin, Philippe J, Bates, Sarah J, Sibley, Carol H

“…PURPOSE OF REVIEWEffective surveillance for and rapid identification of evolved antimalarial resistance ensures that all patients are treated with efficacious…”
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Characteristics of Plasmodium falciparum dhfr Haplotypes That Confer Pyrimethamine Resistance, Kilifi, Kenya, 1987–2006 by Certain, Laura K., Briceño, Marnie, Kiara, Steven M., Nzila, Alexis M., Watkins, William M., Sibley, Carol Hopkins

“…Resistance to the antimalarial drug sulfadoxine-pyrimethamine (SP) emerged in Plasmodium falciparum from Asia in the 1960s and subsequently spread to Africa…”
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Malaria historians: analyze your old slides by Sibley, Carol Hopkins

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Dihydrofolate Reductase Mutations in Plasmodium vivax from Indonesia and Therapeutic Response to Sulfadoxine plus Pyrimethamine by Hastings, Michele D., Porter, Kathryn M., Maguire, Jason D., Susanti, Ika, Kania, Winni, Bangs, Michael J., Sibley, Carol Hopkins, Baird, J. Kevin

“…Background. The target enzyme of pyrimethamine is dihydrofolate reductase (DHFR), but little is known about allelic variants of dhfr in Plasmodium vivax…”
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Sensitivity to antifolates and genetic analysis of Plasmodium vivax isolates from Thailand by Rungsihirunrat, Kanchana, Na-Bangchang, Kesara, Hawkins, Vivian N, Mungthin, Mathirut, Sibley, Carol Hopkins

“…We investigated the association between the Plasmodium vivax dihydrofolate reductase (Pvdhfrtas) and the P. vivax dihydropteroate synthase (Pvdhps) genotype…”
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Towards an Understanding of the Mechanism of Pyrimethamine-Sulfadoxine Resistance in Plasmodium falciparum: Genotyping of Dihydrofolate Reductase and Dihydropteroate Synthase of Kenyan Parasites by NZILA, A. M, MBERU, E. K, SULO, J, DAYO, H, WINSTANLEY, P. A, SIBLEY, C. H, WATKINS, W. M

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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NADP super(+) Expels both the Co-factor and a Substrate Analog from the Mycobacterium tuberculosis ThyX Active Site: Opportunities for Anti-bacterial Drug Design by Sampathkumar, P, Turley, S, Sibley, CH, Hol, WGJ

“…The novel flavin-dependent thymidylate synthase, ThyX, is absent in humans but several pathogenic bacteria depend exclusively on ThyX activity to synthesize…”
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Novel Plasmodium vivax dhfr Alleles from the Indonesian Archipelago and Papua New Guinea: Association with Pyrimethamine Resistance Determined by a Saccharomyces cerevisiae Expression System by HASTINGS, Michele D, MAGUIRE, Jason D, BANGS, Michael J, ZIMMERMAN, Peter A, REEDER, John C, BAIRD, J. Kevin, SIBLEY, Carol Hopkins

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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