Search Results - "Sibley, C.P."

Review: Transport across the placenta of mice and women by Dilworth, M.R, Sibley, C.P

“…Abstract Since the advent of technologies to produce genetic knockout and transgenic mice, the number of mouse strains suggested to be useful as models for…”
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Expression of folate transporters in human placenta and implications for homocysteine metabolism by Solanky, N, Requena Jimenez, A, D'Souza, S.W, Sibley, C.P, Glazier, J.D

“…Abstract Poor folate status during pregnancy can lead to elevated maternal plasma levels of homocysteine (Hcy) with associated pregnancy complications and…”
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Obesity and the placenta: A consideration of nutrient exchange mechanisms in relation to aberrant fetal growth by Higgins, L, Greenwood, S.L, Wareing, M, Sibley, C.P, Mills, T.A

“…Abstract The obesity epidemic, including childhood obesity, is rapidly gaining strength as one of the most significant challenges to the health of the global…”
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Third trimester placental volume and biometry measurement: a method-development study by Higgins, L.E, Simcox, L, Sibley, C.P, Heazell, A.E.P, Johnstone, E.D

“…Abstract Objectives To test the hypothesis that third trimester placental biometry and volume can be measured by two-dimensional (2D) and three-dimensional…”
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IFPA Gábor Than Award Lecture: Recognition of placental failure is key to saving babies' lives by Heazell, A.E.P, Worton, S.A, Higgins, L.E, Ingram, E, Johnstone, E.D, Jones, R.L, Sibley, C.P

“…Abstract In high-income countries, placental failure is implicated in up to 65% of cases of stillbirth. Placental failure describes the situation where the…”
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Syncytial nuclear aggregates in normal placenta show increased nuclear condensation, but apoptosis and cytoskeletal redistribution are uncommon by Coleman, S.J, Gerza, L, Jones, C.J.P, Sibley, C.P, Aplin, J.D, Heazell, A.E.P

“…Abstract Introduction Syncytial nuclear aggregates (SNAs) are increased in pregnancy complications; however, little is known about their origin or function…”
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The contribution of SNAT1 to system A amino acid transporter activity in human placental trophoblast by Desforges, M., Greenwood, S.L., Glazier, J.D., Westwood, M., Sibley, C.P.

“…► mRNA levels for SNAT1 are higher than other system A subtype mRNAs in primary human cytotrophoblast. ► SNAT1 knockdown in cytotrophoblast cells significantly…”
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Review: Modelling placental amino acid transfer − From transporters to placental function by Lewis, R.M, Brooks, S, Crocker, I.P, Glazier, J, Hanson, M.A, Johnstone, E.D, Panitchob, N, Please, C.P, Sibley, C.P, Widdows, K.L, Sengers, B.G

“…Abstract Amino acid transfer to the fetus is dependent on several different factors. While these factors can be understood in isolation, it is still not…”
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Placental structure and function in fetal growth restriction and stillbirth by Sibley, C.P, Abrahams, V, Girard, S, Higgins, L, Johnstone, E.D, Jones, R.L, Heazell, A.E.P

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Chorionic plate arterial function is altered in maternal obesity by Hayward, C.E, Higgins, L, Cowley, E.J, Greenwood, S.L, Mills, T.A, Sibley, C.P, Wareing, M

“…Abstract Objectives To characterise Chorionic Plate Artery (CPA) function in maternal obesity, and investigate whether leptin exposure reproduces the obese CPA…”
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Dexamethasone stimulates placental system A transport and trophoblast differentiation in term villous explants by Audette, M.C, Greenwood, S.L, Sibley, C.P, Jones, C.J.P, Challis, J.R.G, Matthews, S.G, Jones, R.L

“…Abstract Synthetic glucocorticoids (GCs) are given to women with threatened preterm labour but their administration has been linked to reduced infant…”
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Defining fetal growth restriction in mice: A standardized and clinically relevant approach by Dilworth, M.R, Kusinski, L.C, Baker, B.C, Renshall, L.J, Greenwood, S.L, Sibley, C.P, Wareing, M

“…Abstract The increasing number of mouse models of fetal growth restriction (FGR) make it crucial to standardize the way FGR is defined. By constructing growth…”
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Analysis of syncytial nuclear aggregates in preeclampsia shows increased sectioning artefacts and decreased inter-villous bridges compared to healthy placentas by Calvert, S.J, Jones, C.J.P, Sibley, C.P, Aplin, J.D, Heazell, A.E.P

“…Abstract Syncytial nuclear aggregates (SNAs) are increased in pregnancy complications and include ‘true’ syncytial knots and inter-villous bridges. Apparent…”
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Utero-Placental Haemodynamics in the Pathogenesis of Pre-Eclampsia by Hutchinson, E.S, Brownbill, P, Jones, N.W, Abrahams, V.M, Baker, P.N, Sibley, C.P, Crocker, I.P

“…Abstract Pre-eclampsia is associated with insufficient adaptations of spiral arteries which theoretically alter haemodynamics within the intervillous space…”
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Effect of young maternal age and skeletal growth on placental growth and development by Hayward, C.E, Greenwood, S.L, Sibley, C.P, Baker, P.N, Jones, R.L

“…Abstract Objectives Teenagers are susceptible to delivering small-for-gestational-age infants. Previous studies implicate continued skeletal growth as a…”
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Isolation of Plasma Membrane Vesicles from Mouse Placenta at Term and Measurement of System A and System β Amino Acid Transporter Activity by Kusinski, L.C, Jones, C.J.P, Baker, P.N, Sibley, C.P, Glazier, J.D

“…Abstract Placental amino acid transport is essential for optimal fetal growth and development, with a reduced fetal provision of amino acids being implicated…”
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Aldosterone and Cortisol Acutely Stimulate Na+ /H+ Exchanger Activity in the Syncytiotrophoblast of the Human Placenta: Effect of Fetal Sex by Speake, P.F, Glazier, J.D, Greenwood, S.L, Sibley, C.P

“…Abstract Na+ /H+ exchanger (NHE) activity regulates intracellular pH (pHi ) in the placental syncytiotrophoblast. In other tissues aldosterone and cortisol…”
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Maternal muscle mass may influence system A activity in human placenta by Lewis, R.M, Greenwood, S.L, Cleal, J.K, Crozier, S.R, Verrall, L, Inskip, H.M, Cameron, I.T, Cooper, C, Sibley, C.P, Hanson, M.A, Godfrey, K.M

“…Abstract During pregnancy, nutrient partitioning between the mother and fetus must balance promoting fetal survival and maintaining nutritional status of the…”
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System A activity and vascular function in the placental-specific Igf2 knockout mouse by Kusinski, L.C, Dilworth, M.R, Baker, P.N, Sibley, C.P, Wareing, M, Glazier, J.D

“…Abstract Objectives Deletion of the placental-specific P0 transcript of the insulin-like growth factor gene ( Igf2 ) reduces placental growth from early…”
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Corticotrophin-releasing Factor and Urocortin Inhibit System A Activity in Term Human Placental Villous Explants by Giovannelli, A, Greenwood, S.L, Desforges, M, Sibley, C.P, Petraglia, F

“…Abstract Plasma corticotrophin-releasing factor (CRF) and urocortin are elevated in preterm labour and/or fetal growth restriction (FGR). FGR is associated…”
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