Search Results - "Sibener, Leah"

Tuning T cell receptor sensitivity through catch bond engineering by Zhao, Xiang, Kolawole, Elizabeth M, Chan, Waipan, Feng, Yinnian, Yang, Xinbo, Gee, Marvin H, Jude, Kevin M, Sibener, Leah V, Fordyce, Polly M, Germain, Ronald N, Evavold, Brian D, Garcia, K Christopher

“…Adoptive cell therapy using engineered T cell receptors (TCRs) is a promising approach for targeting cancer antigens, but tumor-reactive TCRs are often weakly…”
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Crystal Structure of Vδ1 T Cell Receptor in Complex with CD1d-Sulfatide Shows MHC-like Recognition of a Self-Lipid by Human γδ T Cells by Luoma, Adrienne M., Castro, Caitlin D., Mayassi, Toufic, Bembinster, Leslie A., Bai, Li, Picard, Damien, Anderson, Brian, Scharf, Louise, Kung, Jennifer E., Sibener, Leah V., Savage, Paul B., Jabri, Bana, Bendelac, Albert, Adams, Erin J.

“…The nature of the antigens recognized by γδ T cells and their potential recognition of major histocompatibility complex (MHC)-like molecules has remained…”
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Selective targeting of engineered T cells using orthogonal IL-2 cytokine-receptor complexes by Sockolosky, Jonathan T, Trotta, Eleonora, Parisi, Giulia, Picton, Lora, Su, Leon L, Le, Alan C, Chhabra, Akanksha, Silveria, Stephanie L, George, Benson M, King, Indigo C, Tiffany, Matthew R, Jude, Kevin, Sibener, Leah V, Baker, David, Shizuru, Judith A, Ribas, Antoni, Bluestone, Jeffrey A, Garcia, K Christopher

“…Interleukin-2 (IL-2) is a cytokine required for effector T cell expansion, survival, and function, especially for engineered T cells in adoptive cell…”
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Genetic variation in MHC proteins is associated with T cell receptor expression biases by Sharon, Eilon, Sibener, Leah V, Battle, Alexis, Fraser, Hunter B, Garcia, K Christopher, Pritchard, Jonathan K

“…Jonathan Pritchard, Christopher Garcia and colleagues examine associations between different T cell receptor V genes and MHC alleles by eQTL mapping. They find…”
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Isolation of a Structural Mechanism for Uncoupling T Cell Receptor Signaling from Peptide-MHC Binding by Sibener, Leah V., Fernandes, Ricardo A., Kolawole, Elizabeth M., Carbone, Catherine B., Liu, Fan, McAffee, Darren, Birnbaum, Michael E., Yang, Xinbo, Su, Laura F., Yu, Wong, Dong, Shen, Gee, Marvin H., Jude, Kevin M., Davis, Mark M., Groves, Jay T., Goddard, William A., Heath, James R., Evavold, Brian D., Vale, Ronald D., Garcia, K. Christopher

“…TCR-signaling strength generally correlates with peptide-MHC binding affinity; however, exceptions exist. We find high-affinity, yet non-stimulatory,…”
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Antigen Identification for Orphan T Cell Receptors Expressed on Tumor-Infiltrating Lymphocytes by Gee, Marvin H., Han, Arnold, Lofgren, Shane M., Beausang, John F., Mendoza, Juan L., Birnbaum, Michael E., Bethune, Michael T., Fischer, Suzanne, Yang, Xinbo, Gomez-Eerland, Raquel, Bingham, David B., Sibener, Leah V., Fernandes, Ricardo A., Velasco, Andrew, Baltimore, David, Schumacher, Ton N., Khatri, Purvesh, Quake, Stephen R., Davis, Mark M., Garcia, K. Christopher

“…The immune system can mount T cell responses against tumors; however, the antigen specificities of tumor-infiltrating lymphocytes (TILs) are not well…”
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Crystal Structure of V delta 1 T Cell Receptor in Complex with CD1d-Sulfatide Shows MHC-like Recognition of a Self-Lipid by Human gamma delta T Cells by Luoma, Adrienne M, Castro, Caitlin D, Mayassi, Toufic, Bembinster, Leslie A, Bai, Li, Picard, Damien, Anderson, Brian, Scharf, Louise, Kung, Jennifer E, Sibener, Leah V, Savage, Paul B, Jabri, Bana, Bendelac, Albert, Adams, Erin J

“…The nature of the antigens recognized by gamma delta T cells and their potential recognition of major histocompatibility complex (MHC)-like molecules has…”
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Structural interplay between germline interactions and adaptive recognition determines the bandwidth of TCR-peptide-MHC cross-reactivity by Adams, Jarrett J, Narayanan, Samanthi, Birnbaum, Michael E, Sidhu, Sachdev S, Blevins, Sydney J, Gee, Marvin H, Sibener, Leah V, Baker, Brian M, Kranz, David M, Garcia, K Christopher

“…The TCR-peptide-MHC interface is composed of conserved and diverse regions, but the relative contributions of each in shaping T cell recognition remain…”
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Intracellular targets as source for cleaner targets for the treatment of solid tumors by Gerber, Hans-Peter, Sibener, Leah V., Lee, Luke J., Gee, Marvin

“…Intracellular proteins are degraded by a proteasome into small peptide fragments. These peptides are then transported into the ER lumen by TAP (transporter…”
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TCR ligand potency differentially impacts PD-1 inhibitory effects on diverse signaling pathways by Chan, Waipan, Cao, Yuqi M, Zhao, Xiang, Schrom, Edward C, Jia, Dongya, Song, Jian, Sibener, Leah V, Dong, Shen, Fernandes, Ricardo A, Bradfield, Clinton J, Smelkinson, Margery, Kabat, Juraj, Hor, Jyh Liang, Altan-Bonnet, Grégoire, Garcia, K Christopher, Germain, Ronald N

“…Checkpoint blockade revolutionized cancer therapy, but we still lack a quantitative, mechanistic understanding of how inhibitory receptors affect diverse…”
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Discovery of surrogate agonists for visceral fat Treg cells that modulate metabolic indices in vivo by Fernandes, Ricardo A, Li, Chaoran, Wang, Gang, Yang, Xinbo, Savvides, Christina S, Glassman, Caleb R, Dong, Shen, Luxenberg, Eric, Sibener, Leah V, Birnbaum, Michael E, Benoist, Christophe, Mathis, Diane, Garcia, K Christopher

“…T regulatory (Treg) cells play vital roles in modulating immunity and tissue homeostasis. Their actions depend on TCR recognition of peptide-MHC molecules; yet…”
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Stress-testing the relationship between T cell receptor/peptide-MHC affinity and cross-reactivity using peptide velcro by Gee, Marvin H., Sibener, Leah V., Birnbaum, Michael E., Jude, Kevin M., Yang, Xinbo, Fernandes, Ricardo A., Mendoza, Juan L., Glassman, Caleb R., Garcia, K. Christopher

“…T cell receptors (TCRs) bind to peptide-major histocompatibility complex (pMHC) with low affinity (K d ∼ μM), which is generally assumed to facilitate…”
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Lysophospholipid presentation by CD1d and recognition by a human Natural Killer T-cell receptor by López-Sagaseta, Jacinto, Sibener, Leah V, Kung, Jennifer E, Gumperz, Jenny, Adams, Erin J

“…Invariant Natural Killer T (iNKT) cells use highly restricted αβ T cell receptors (TCRs) to probe the repertoire of lipids presented by CD1d molecules. Here,…”
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Voices of biotech leaders by Bosley, Katrine, Casebourn, Charlotte, Chan, Priscilla, Chen, Janice, Chen, Michael, Church, George, Cumbers, John, de Wouters, Tomas, Dewey-Hagborg, Heather, Duportet, Xavier, Ene-Obong, Abasi, Elizondo, Arturo, Farrar, Jeremy, Gates, Bill, Gatto, Francesco, Giwa, Sebastian, Godec, Jernej, Gold, Silvia, LeProust, Emily, Lunshof, Jeantine, Martucci, Eddie, Heath, Michelle McMurray, Mellad, Jason, Oudova, Veronika, Oxman, Neri, Regev, Aviv, Richardson, Sarah, Scott, Christopher Thomas, Sherkow, Jake, Sibener, Leah, Tarragó, Teresa, Terry, Sharon, Venter, J. Craig, Wang, Spin, Wickramasekara, Sajith, Yadi, Hakim, Yang, Luhan, Zhao, Bowen

“…Nature Biotechnology asks a selection of leaders from across biotech to look at the future of the sector and make some predictions for the coming years…”
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Publisher Correction: Voices of biotech leaders by Bosley, Katrine, Casebourn, Charlotte, Chan, Priscilla, Chen, Janice, Chen, Michael, Church, George, Cumbers, John, de Wouters, Tomas, Dewey-Hagborg, Heather, Duportet, Xavier, Ene-Obong, Abasi, Elizondo, Arturo, Farrar, Jeremy, Gates, Bill, Gatto, Francesco, Giwa, Sebastian, Godec, Jernej, Gold, Silvia, LeProust, Emily, Lunshof, Jeantine, Martucci, Eddie, Heath, Michelle McMurray, Mellad, Jason, Oudova, Veronika, Oxman, Neri, Regev, Aviv, Richardson, Sarah, Scott, Christopher Thomas, Sherkow, Jake, Sibener, Leah, Tarragó, Teresa, Terry, Sharon, Venter, J. Craig, Wang, Spin, Wickramasekara, Sajith, Yadi, Hakim, Yang, Luhan, Zhao, Bowen

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Abstract LBA006: Identification of novel, tumor specific pHLA targets recognized by TILs from CPI responders in a high-throughput, high-diversity pHLA library screening platform (3T-TRACE) by Gerber, Hans-Peter, Gee, Marvin, Sibener, Leah

“…Background The ideal cancer target antigen is selectively expressed on neoplastic cells, absent on normal tissues, and contributes to the survival of cancer…”
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Nanoscale artificial antigen presenting cells for T cell immunotherapy by Perica, Karlo, De León Medero, Andrés, Durai, Malarvizhi, Chiu, Yen Ling, Bieler, Joan Glick, Sibener, Leah, Niemöller, Michaela, Assenmacher, Mario, Richter, Anne, Edidin, Michael, Oelke, Mathias, Schneck, Jonathan

“…Abstract Artificial antigen presenting cells (aAPC), which deliver stimulatory signals to cytotoxic lymphocytes, are a powerful tool for both adoptive and…”
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Isolation and visualization of a structural trigger that uncouples TCR signaling from pMHC binding by Sibener, Leah V., Fernandes, Ricardo A., Kolawole, Elizabeth M., Carbone, Catherine B., Liu, Fan, McAffee, Darren, Birnbaum, Michael E., Yang, Xinbo, Su, Laura F., Yu, Wong, Dong, Shen, Gee, Marvin H., Jude, Kevin M., Davis, Mark M., Groves, Jay T., Goddard, William A., Heath, James R., Evavold, Brian D., Vale, Ronald D., Garcia, K. Christopher

“…TCR signaling strength generally correlates with peptide-MHC binding affinity; however, exceptions exist. We find high-affinity, yet non-stimulatory…”
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Isolation of a Structural Mechanism for Uncoupling T Cell Receptor Signaling from Peptide-MHC Binding by Sibener, Leah V., Fernandes, Ricardo A., Kolawole, Elizabeth M., Carbone, Catherine B., Liu, Fan, McAffee, Darren, Birnbaum, Michael E., Yang, Xinbo, Su, Laura F., Yu, Wong, Dong, Shen, Gee, Marvin H., Jude, Kevin M., Davis, Mark M., Groves, Jay T., Goddard, III, William A., Heath, James R., Evavold, Brian D., Vale, Ronald D., Garcia, K. Christopher

“…TCR-signaling strength generally correlates with peptide-MHC binding affinity; however, exceptions exist. We find high-affinity, yet non-stimulatory,…”
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Abstract 578: A functional approach to identifying and engineering TCRs results in highly-potent and specific TCRs for TCR-T cell therapy by Leonard, John D., Ramirez, Alejandro, Romero, Jason, Kleiner, Jake, Dreux, Joanna, Hegde, Bindu, Xie, Bryan, Sharathchandra, Akshay, Katz, Nathan, DeAlmeida, Venita I., Gerber, Hans-Peter, Gee, Marvin H., Sibener, Leah V.

“…Peptide-HLA (pHLA)- targeting therapeutics, such as T cell receptor-engineered T cells (TCR-T), have had clinical success in treating solid tumors. However,…”
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